MINK1
-
Official Full Name
misshapen-like kinase 1
-
Overview
This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. Alternative splicing occurs at this locus and four transcript variants encoding distinct isoforms have been identified. -
Synonyms
MINK1; misshapen-like kinase 1; misshapen like kinase 1 (zebrafish); B55; MAP4K6; MINK; misshapen/NIK related kinase; YSK2; ZC3; MEKKK 6; MEK kinase kinase 6; GCK family kinase MINK; misshapen/NIK-related kinase; MAPK/ERK kinase kinase kinase 6; serine/th;
- Recombinant Proteins
- Human
- Human
- Mouse
- Zebrafish
- HEK293
- HEK293T
- Insect Cell
- Mammalian Cell
- Sf21
- Sf9 Insect Cell
- GST
- GST|His
- His
- Myc
- DDK
- Myc|DDK
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- MINK1 Related Articles
MINK1 involved in several pathways and played different roles in them. We selected most pathways MINK1 participated on our site, such as Cellular Senescence, Cellular responses to stress, Insulin Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with MINK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cellular Senescence | H3F3B.1;LMNB1;PHC2;HIST4H4;EP400;EHMT2;ACD;SUZ12A;TINF2 |
| Cellular responses to stress | TXN;EP400;MINK1;HSPH1;GABARAP;LC3;RNF2;HIF1AN;ACD |
| Insulin Signaling | MYO1C;GRB14;GRB10;MAPK4;MAP3K2;RRAD;STXBP4;REG1A;STXBP2 |
| MAPK signaling pathway | FLNC;CACNG6;CACNA2D4;MAP4K4;CACNA1H;PTPRR;CDC42L;RAC3B;RPS6KA1 |
| Oxidative Stress Induced Senescence | BMI1B;TNIK;EED;CBX6A;CBX6;CBX8;CBX8A;KDM6B;PHC1 |
MINK1 has several biochemical functions, for example, ATP binding, NOT MAP kinase kinase kinase kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MINK1 itself. We selected most functions MINK1 had, and list some proteins which have the same functions with MINK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ATP2B2;RLN1;ASNA1;ACTB1;ABL1;AK8;TK2;PRKCA;NAT1 |
| NOT MAP kinase kinase kinase kinase activity | TNIKB;TNIK;MINK1;NRK;TNIKA;MAP4K4 |
| protein binding | SNTB2;IL17RA;GTF3C5;PPIL2;GIMAP5;EPHA10;CPSF6;C11orf49;PRKAB2 |
| protein kinase activity | RLN1;NPR1;MKNK2B;CAMKVB;HIPK2;MAP3K3;GRK1;CAMK1GB;STK35L |
| protein serine/threonine kinase activity | AKT1;TAOK3;NUAK1;STRC;NEK7;PIK3CG;PAK2A;LATS2;FASTK |
MINK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MINK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MINK1.
HSF1; IER5; abl-tide; MAP4K4; HSP90AB1; RAP2A
- Q&As
- Reviews
Ask a Question for All MINK1 Products
Required fields are marked with *
My Review for All MINK1 Products
Required fields are marked with *
