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PCCA

  • Official Full Name

    propionyl CoA carboxylase, alpha polypeptide

  • Overview

    The protein encoded by this gene is the alpha subunit of the heterodimeric mitochondrial enzyme Propionyl-CoA carboxylase. PCCA encodes the biotin-binding region of this enzyme. Mutations in either PCCA or PCCB (encoding the beta subunit) lead to an enzyme deficiency resulting in propionic acidemia. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    PCCA; propionyl CoA carboxylase, alpha polypeptide; propionyl Coenzyme A carboxylase, alpha polypeptide; propionyl-CoA carboxylase alpha chain, mitochondrial; PCCase subunit alpha; Propanoyl CoA:carbon dioxide ligase subunit alpha; Propionyl CoA carboxylase alpha chain; Propionyl CoA carboxylase alpha chain mitochondrial; Propionyl Coenzyme A Carboxylase Alpha Polypeptide; PCCase alpha subunit; pccA complementation group; propanoyl-CoA:carbon dioxide ligase alpha subunit;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • c
  • Myc|DDK
  • Flag
  • His
  • His (Fc)
  • Avi
  • His|T7
  • MYC
  • DDK
  • N/A
  • N
  • GST
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PCCA-8176H Recombinant Human PCCA protein, His & T7-tagged E.coli His/T7 Val580~Glu728 (Accession # P05165)
Human PCCA-3400HCL Recombinant Human PCCA 293 Cell Lysate HEK293 N/A
Human PCCA-1617H-B Recombinant Human PCCA Protein Pre-coupled Magnetic Beads HEK293
Human PCCA-502HFL Recombinant Full Length Human PCCA Protein, C-Flag-tagged Mammalian cells Flag
Human PCCA-2785H Recombinant Human PCCA protein, His-tagged E.coli His 344 - 703 aa
Human PCCA-12H Recombinant Human PCCA Protein, C-MYC/DDK-tagged HEK293 c-Myc/DDK
Human PCCA-4806H Recombinant Human PCCA Protein (Val580-Glu728), N-His tagged E.coli N-His Val580-Glu728
Human PCCA-1617H Recombinant Human PCCA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Pcca-1902M Recombinant Mouse Pcca Protein, His&GST-tagged E.coli N-His&GST Asn593-Glu724
Mouse Pcca-484M Recombinant Mouse Pcca Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat PCCA-4292R Recombinant Rat PCCA Protein Mammalian Cell His
Rat PCCA-3954R-B Recombinant Rat PCCA Protein Pre-coupled Magnetic Beads HEK293
Rat PCCA-3954R Recombinant Rat PCCA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish PCCA-842Z Recombinant Zebrafish PCCA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PCCA Related Articles

PCCA involved in several pathways and played different roles in them. We selected most pathways PCCA participated on our site, such as Valine, leucine and isoleucine degradation, Glyoxylate and dicarboxylate metabolism, Propanoate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCCA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Valine, leucine and isoleucine degradationHIBADH;OXCT2A;HMGCLL1;ACAT1;MUT;HADHAB;AUH;ACADSB;DLDH
Glyoxylate and dicarboxylate metabolismAMT;GCSH;PCCA;GRHPRA;MDH1AA;GLULB;PCCB;CAT;ACO2
Propanoate metabolismECHDC1;BCKDHB;LDHBA;MLYCD;PCCA;PCCB;ackA;ACSS1;MCEE
Metabolic pathwaysATP6V1G3;MAT1A;COX10;CEL.1;MPST;ALDOCA;NDUFB8;TPI1B;CYP24A1
Carbon metabolismPFKM;PGP;GPIB;ADPGK;PC;SDHA;PRPS1B;ENO2;FBP1A

PCCA has several biochemical functions, for example, ATP binding, biotin binding, biotin carboxylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PCCA itself. We selected most functions PCCA had, and list some proteins which have the same functions with PCCA. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPKMYT1;CKMT1;GK5;FYNA;TOR1L1;RPS6KB1;KIF1C;TLK1B;ABCA5
biotin bindingPCXB;MCCC1;HLCS;PCCA;PCXA;AVR2;PC
biotin carboxylase activityPC;PCCA;PCXA;PCXB;MCCC1;ACACB;ACACA
enzyme bindingPTEN;KIAA1967;POR;RAD9;SCNM1-PS;HIST1H2AN;PPP3CB;PPARG;CBX1
metal ion bindingC6AST1;UNC13B;MGAT5B;BCL11BA;ZFP536;ZNF562;EXT1B;NEK7;ZBTB2A
propionyl-CoA carboxylase activityPCCA;PCCB

PCCA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCCA here. Most of them are supplied by our site. Hope this information will be useful for your research of PCCA.

PARP2; recB; BAG2; US11; IFIT1; PPP2R2B; EBNA-LP; SIRT4

Stadler, SC; Polanetz, R; et al. Mitochondrial targeting signals and mature peptides of 3-methylcrotonyl-CoA carboxylase. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 334:939-946(2005).
Muro, S; Perez, B; et al. Effect of PCCB gene mutations on the heteromeric and homomeric assembly of Propionyl-CoA carboxylase. MOLECULAR GENETICS AND METABOLISM 74:476-483(2001).
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