PDXK
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Official Full Name
pyridoxal (pyridoxine, vitamin B6) kinase
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Overview
The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. -
Synonyms
PDXK; pyridoxal (pyridoxine, vitamin B6) kinase; C21orf97, C21orf124, chromosome 21 open reading frame 97 , chromosome 21 open reading frame 124; pyridoxal kinase; FLJ21324; FLJ31940; MGC15873; PKH; PNK; PRED79; pyridoxine kinase; vitamin B6 kinase; pyr;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Others
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
PDXK involved in several pathways and played different roles in them. We selected most pathways PDXK participated on our site, such as Vitamin B metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDXK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Vitamin B metabolism | PSAT1;PDXKA;AOX3;PHOSPHO2;PDXK;PDXKB;PDXP;AOX4;AOX1 |
| Metabolic pathways | PIP5K1AB;CERS4;NDUFA11;ATP6V0E;GCNT4;HK1;DBH;CYP4A10;FPGS |
PDXK has several biochemical functions, for example, ATP binding, drug binding, kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDXK itself. We selected most functions PDXK had, and list some proteins which have the same functions with PDXK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | DYRK1B;CKMT2;CLK2;DGKAA;CMPK;CDK11B;STK38A;EIF2B2;CSNK1G2A |
| drug binding | PYGL;UGT1A7;TOP2A;NAMPT;CHRNA3;GSTP2;PPARD;P2RX4;SFRP1 |
| kinase activity | INSRA;PLK1;PANK1A;CMPK;GM7168;JAK2A;PKZ;AKT3A;CAMK1GB |
| lithium ion binding | PDXK;IMPA1 |
| magnesium ion binding | IMPA2;PI4K2A;TREX2;PRPS1L1;PCK1;PDXP;RPS6KAL;SRR;EYA2 |
| metal ion binding | PC;CELA1;TRIM2A;RPAIN;ZFP579;ZNF165;ZNF488;HDAC7A;PRKCHB |
| nucleotide binding | TTLL11;RBM11;MAP2K4B;CRY1;HNRNPH3;ATP2B1;SNRPA;SRPK1A;CDC6 |
| potassium ion binding | SLC24A2;ATP1A1;PKLR;PKMA;SLC24A4A;SLC24A1;HDAC4;KCNJ11;SLC24A4 |
| protein homodimerization activity | APOBEC3G;SNRPC;CPOX;PVRL1;STOM;PFKM;PEX11B;GABPB2;CEACAM1 |
| pyridoxal binding | |
| pyridoxal kinase activity | PDXK;PDXKB;PDXKA |
| pyridoxal phosphate binding | PYGMB;LOC650128;GAD1B;AGXT2L2;CBS;ACCSL;MARC1;TAT;CTHL |
| sodium ion binding | CAPN3;SLC24A4A;SLC24A4;ATP1A1;SLC24A5;SLC24A2;SCN9A;SLC34A2;SLC24A1 |
| transferase activity | MRPL2;TOMT;NMT1A;TNIKB;MBOAT4;GGACT.2;SULT1ST4;Art2b;B4GALNT4 |
| zinc ion binding | TRIM12A;ADAM23;DEF8;TRIM55A;ZCCHC8;TRIM11;KDM5B;KDM5C;Adam6 |
PDXK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDXK here. Most of them are supplied by our site. Hope this information will be useful for your research of PDXK.
Ywhae; Kcnma1; Dlg4; Pgls
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