Pyridoxal kinase
Cat.No. : | CBCRY19 |
- Specification
- Gene Information
- Related Products
Cat. No. : | CBCRY19 |
Background : | Pyridoxal kinase, a member of the ribokinase superfamily, catalyzes the ATP-dependent phosphorylation reaction of vitamin B6 and is an essential enzyme in the formation of pyridoxal-5"-phosphate, a key cofactor for over 100 enzymes. Pyridoxal kinase is thus regarded as a potential target for pharmacological agents. Structure comparison reveals that the key 12-residue peptide over the active site in HPLK is a beta-strand/loop/beta-strand flap, while the corresponding peptide in sheep brain enzyme adopts a loop conformation. Moreover, HPLK possesses a more hydrophobic ATP-binding pocket. |
Protein Classification : | Transferase |
Structure Weight : | 74135.20 Da |
Polymer : | 1 |
Molecule : | Pyridoxal kinase |
Chain Length : | 327 amino acids |
PDB ID : | 2F7K |
MMDB ID : | 39840 |
Source : | E.coli |
Method : | X-Ray Diffraction |
Resolution : | 2.8Å |
Reference : | Cao, P., Gong, Y., Tang, L., Leung, Y.C., Jiang, T.(2006) Crystal structure of human pyridoxal kinaseJ.Struct.Biol.154: 327-332 |
Gene Name : | PDXK |
Synonyms : | C21orf124; C21orf97; EC 2.7.1.35; DKFZp566A071; FLJ31940; FLJ37311; FLJ21324; MGC15873; MGC31754; MGC52346; PKH; PNK; PRED79; pyridoxal kinase; pyridoxamine kinase; pyridoxine kinase; vitamin B6 kinase; chromosome 21 open reading reame 124; chromosome 21 open reading frame 97 |
UniProt ID : | O00764 |
Gene ID : | 8566 |
Chromosome Location : | 21q22.3 |
Function : | ATP binding; lithium ion binding; magnesium ion binding; nucleotide binding; potassium ion binding; protein homodimerization activity; pyridoxal kinase activity; sodium ion binding; transferase activity; zinc ion binding |
Products Types
◆ Recombinant Protein | ||
Pdxk-4782M | Recombinant Mouse Pdxk Protein, Myc/DDK-tagged | +Inquiry |
PDXK-4023R | Recombinant Rat PDXK Protein, His (Fc)-Avi-tagged | +Inquiry |
PDXK-6621M | Recombinant Mouse PDXK Protein, His (Fc)-Avi-tagged | +Inquiry |
Pdxk-1845M | Recombinant Mouse Pdxk protein, His & T7-tagged | +Inquiry |
PDXK-12603M | Recombinant Mouse PDXK Protein | +Inquiry |
◆ Lysates | ||
PDXK-3317HCL | Recombinant Human PDXK 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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