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PILRB

  • Official Full Name

    paired immunoglobin-like type 2 receptor beta

  • Overview

    Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the non-ITIM-bearing member of the receptor pair, which has a truncated cytoplasmic tail relative to its ITIM-bearing partner, and functions in the activating role. Alternatively spliced transcript variants have been noted for this gene, but the full-length nature of many is not known.
  • Synonyms

    PILRB; paired immunoglobin-like type 2 receptor beta; paired immunoglobulin-like type 2 receptor beta; FDFACT1; FDFACT2; activating receptor PILRbeta; cell surface receptor FDFACT; activating receptor PILR-beta; cell surface receptor FDFACT1; cell surface;

  • Recombinant Proteins
  • Human
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Wheat Germ
  • GST
  • His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PILRB-1720H Recombinant Human PILRB, GST-tagged E.coli GST 20-188aa
Human PILRB-1721H Recombinant Human PILRB protein, GST-tagged Wheat Germ GST 1 a.a. - 227 a.a.
Human PILRB-1722H Recombinant Human PILRB protein, GST-tagged Wheat Germ GST 81 a.a. - 180 a.a.
Human PILRB-638HF Recombinant Full Length Human PILRB Protein, GST-tagged In Vitro Cell Free System GST 227 amino acids
Human PILRB-636HF Recombinant Full Length Human PILRB Protein, GST-tagged In Vitro Cell Free System GST 227 amino acids
Human PILRB-521H Recombinant Human PILRB Protein, His-tagged HEK293 His Gln20-Ala189
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PILRB Related Research Area

PILRB involved in several pathways and played different roles in them. We selected most pathways PILRB participated on our site, such as B Cell Receptor Signaling Pathway, IL-3 Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PILRB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
B Cell Receptor Signaling PathwayPPP3R2;NFKBIA;ITPR2;IFITM1;CDK4;BLNK;RAC1;LIME1;Cd79a, Cd79b
IL-3 Signaling PathwayPILRB;BIRC5A;GATA1;KCNIP3B;GATA2;GNB2L1;BMX;CISH;SPI1B

PILRB has several biochemical functions, for example, MHC class I protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PILRB itself. We selected most functions PILRB had, and list some proteins which have the same functions with PILRB. You can find most of the proteins on our site.

Function Related Protein
MHC class I protein bindingHLA-E;TAP1;TUBB;TAPBP;ATP5B;CD8A;CD244;Pilrb1;DERL1
protein bindingSLC25A6;PTPN22;GNG5;PBXIP1;H3F3A;TACR1;DLX2;CETN2;SPAG5

PILRB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PILRB here. Most of them are supplied by our site. Hope this information will be useful for your research of PILRB.

ABHD16A; menB; katG

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