PLCB1
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Official Full Name
Plcb1 phospholipase C, beta 1
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Synonyms
PLCB1; phospholipase C, beta 1; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1; PLC-154; PLC-beta-1; phospholipase C-beta-1; phospholipase C-beta-1a; phosphoinositide phospholipase C; phosphoinositide phospholipase C-beta-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1; Plcb; AI132408; mKIAA0581; 3110043I21Rik;
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- Human
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- Mammalian cells
- Flag
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- PLCB1 Related Articles
- PLCB1 Related Signal Pathway
PLCB1 involved in several pathways and played different roles in them. We selected most pathways PLCB1 participated on our site, such as Inositol phosphate metabolism, Metabolic pathways, Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLCB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inositol phosphate metabolism | MTMR7;PI4KA;TPI1;INPP5D;INPPL1;PIK3C3;TPI1A;INPP5K;PIP4K2A |
| Metabolic pathways | GLCE;PLA2G7;CNDP2;ybaS;CBR1L;GALNT2;EPHX2;GLULC;FAM213B |
| Rap signaling pathway | PDGFRB;MAP2K6;KITLG;PRKCB;VASP;PIK3R2;FGF10;Fgf15;RAC2 |
| Calcium signaling pathway | PHKB;STIM1;EGFRA;GRIN1;PDE1A;HTR5AL;P2RX4A;CD38;PRKACG |
| cGMP-PKG signaling pathway | Adcy4;PPP3CB;NOS3;CREB3L3;RGS2;SLC25A6;MYH7;RHOA;SLC8A1 |
| Chemokine signaling pathway | CXCL12;GNG10;CCL16;CXCL16;PRKACG;CCL24;CCL4L1;STAT3;CCL14 |
| Phosphatidylinositol signaling system | MTMR2;INPP1;TMEM55A;PRKCA;PIP5K1A;CALM1A;INPP5K;PIK3CG;MTMR1A |
| Sphingolipid signaling pathway | NRAS;FYN;MAPK8;GAB2;SGMS1;PLCB3;MAP2K2;GNAI1;PPP2R5C |
| Phospholipase D signaling pathway | GRM3;INS;SOS1;KIT;PLCB3;AVP;PLD1;NRAS;Pdgfa&Pdgfb |
| Adrenergic signaling in cardiomyocytes | CACNA1SA;CACNB2A;CACNG2;ADRB2A;ACTC1A;PIK3R3A;CALM2B;ATF4;ATP2B2 |
| Vascular smooth muscle contraction | PPP1CC;PRKCQ;PTGIR;ARAF;PRKCHA;GNAQ;MYL6;MYLK;PRKACAB |
| Wnt signaling pathway | WNT5A;FBXW11A;CAMK2D;DKK1B;WNT4;RAC1;VANGL1;ROCK2;WNT2 |
| Gap junction | PRKACBB;ADRB3B;RAF1;GUCY1B3;MAP2K2A;TUBB;Adcy4;DRD1A;CX35B |
| Platelet activation | PLA2G4C;ITGA2B;MYLK2;PIK3R3;PLA2G4A;TBXAS1;STIM1;FCGR2A;PPP1CC |
| Circadian entrainment | PRKACG;GNG4;RYR1;GNB3;PER1;GNG2;PRKG1;GNG3;CALML5 |
| Long-term potentiation | KRAS;RPS6KA1;PPP1CA;GRM1;MAPK3;PRKACA;CALML3;PPP1CB;PPP1CC |
| Retrograde endocannabinoid signaling | PRKACG;GABRA4;GNAI3;GRIA4;MAPK3;DAGLB;PRKCB;GABRA2;GNAQ |
| Glutamatergic synapse | SHANK2;SHANK3;GNG5;PPP3CB;GNAI2;GNAI3;MAPK1;SLC17A7;GRM4 |
| Cholinergic synapse | KCNJ14;GNGT2;KRAS;MAPK3;CHRNA3;CHRNB4;KCNQ3;GNAO1;PRKCG |
| Serotonergic synapse | TRPC1;CYP4X1;HTR2A;SLC18A1;ITPR3;GABRB1;GNAS;PLA2G4C;CYP2C37 |
| Dopaminergic synapse | PPP2CB;DRD4;ATF6B;SCN1A;KCNJ3;GRIA4;PPP2R1B;TH;GNGT1 |
| Long-term depression | GRIA3;HRAS;RYR1;MAPK1;PRKCB;MAP2K2;GRIA2;PRKG2;ARAF |
| Inflammatory mediator regulation of TRP channels | CYP2C50;PLA2G4C;PIK3R2;PLA2G6;MAPK11;PIK3CG;CAMK2D;Adcy4;TRPM8 |
| Insulin secretion | ATP1B2;SLC2A1;GPR119;PRKACB;INS1;PLCB1;RYR2;CREB3L2;STX1A |
| GnRH signaling pathway | MAPK7;MAPK10;GNRHR;MAP2K7;FSHB;MAPK8A;ADCY1B;MAPK9;PRKACBA |
| Estrogen signaling pathway | HSPA2;HSPA8;GNAI1;PLCB3;SHC4;HSPA6;AKT1;PIK3CD;SP1 |
| Melanogenesis | CAMK2D1;FZD7;WNT11B;WNT5B;ADCY2B;CAMK2G;EDNRB2;FZD3B;CAMK2B1 |
| Thyroid hormone synthesis | PLCB1;TSHR;FXYD2;ATP1A2;GPX6;TTF2;GPX2;GNAS;ATP1B1 |
| Thyroid hormone signaling pathway | SLC2A1;RHEB;ATP1A2;PIK3CB;PRKACG;PIK3CA;HDAC1;ATP2A2;FOXO1 |
| Oxytocin signaling pathway | PIK3CD;CACNG7;PTGS2;NOS3;PLA2G4F;CACNG6;PPP1CB;PIK3CG;MYL6B |
| Renin secretion | PRKG2;AGTR1B;GNAI1;CALM1;PLCB2;GUCY1B3;NPR1;PPP3CB;PDE1C |
| Aldosterone synthesis and secretion | ATF4;HSD3B5;AGTR1B;SLC14A2;CALML5;CREB3;AGTR1A;CAMK2D;LIPE |
| Endocrine and other factor-regulated calcium reabsorption | RAB11A;CALB1;KLK1B3;ATP2B1;PRKACB;KLK1B9;ATP1A3;ATP1B3;ATP1B4 |
| Salivary secretion | STATH;NOS1;PRH2;HTN1;PLCB1;PRB1;LPO;ATP1A4;PRKCB |
| Gastric acid secretion | CALML5;KCNJ16;CAMK2G;Slc4a2;PRKACA;CAMK2D;MYLK4;KCNJ10;MYLK |
| Pancreatic secretion | CPA3;CD38;ATP2B4;PLCB2;SCTR;KCNMA1;PRSS2;CPA2;ATP1B3 |
| Alzheimers disease | COX6B2;NDUFB6;NDUFA5;NDUFB7;APH1B;NDUFA12;COX7A2;IL1B;NDUFS6 |
| Huntingtons disease | BBC3;COX5A;PPIF;TP53;ATP5F1;DNAH14;DNAH11;HIP1;POLR2E |
| Chagas disease (American trypanosomiasis) | PPP2R1B;CCL3;FASLG;CCL5;CFLAR;TLR6;PLCB2;AKT1;PPP2CB |
| African trypanosomiasis | VCAM1;PLCB1;F2RL1;IL18;HBA2;PLCB3;GNAQ;HBB-B1;IFNG |
| Amoebiasis | LAMB4;ADCY1;IL1R1;IL-8;PIK3R3;IL1B;COL27A1;SERPINB4;SERPINB13 |
| Pathways in cancer | SMAD3;PIK3R5;CKS2;LPAR4;BIRC3;TGFBR1;CTNNA3;WNT1;PTGER4 |
PLCB1 has several biochemical functions, for example, GTPase activator activity, calcium ion binding, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLCB1 itself. We selected most functions PLCB1 had, and list some proteins which have the same functions with PLCB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | ALS2CL;RGS2;LRRK2;TBC1D3;NCKAP1L;TBC1D9B;ALDH1A1;PLEKHG6;TBC1D3C |
| calcium ion binding | PKD2L1;CETN1;CHP;PLCD1;EMR4;SYTL4;PCDH2G16;NELL2;S100A8 |
| calmodulin binding | EEF2K;NETO2;MAP2;SNTB1;PHKA1;PHKG1A;TRPV1;SMTNL1;ATPIF1 |
| enzyme binding | PHKG1;HSPA6;DHCR24;UBE2L3;UGT1A6A;THRB;EIF2AK3;BIRC5;SCARB2 |
| lamin binding | SUN1;TMEM201;NARF;SYNE1;PPP4C;IFI27;BNIP3L;TMPO;SUN2 |
| phosphatidylinositol phospholipase C activity | PLCZ1;PLCB4;PLCD1B;PLCL1;CHRM5;PLCL2;C3AR1;EDNRA;PLCD1A |
| phosphatidylinositol-4,5-bisphosphate binding | RAB35;RAG2;TULP3;ANXA8;ADAP2;TWF1;MYO1G;Apba1;AMER2 |
| protein binding | THRA;IFT27;MPP1;TOX4;DOHH;PRRG2;STX18;NR0B1;CABP5 |
| protein homodimerization activity | NOS2;ATG7;HSP90AA1;TOP2A;NR6A1;AMBP;TERF1;S100A1;HLA-G |
| signal transducer activity | Sectm1a;TAS2R121;TAS2R109;SH2B3;OLFR497;PTK2;AKAP13;STAT6;TFG |
PLCB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLCB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLCB1.
CTBP2; TFCP2; CTBP1; CTBP2; CEP76; SPTBN1
Ichishima, K; Yamamoto, S; et al. alpha(1)-Adrenoceptor-mediated depletion of phosphatidylinositol 4, 5-bisphosphate inhibits activation of volume-regulated anion channels in mouse ventricular myocytes. BRITISH JOURNAL OF PHARMACOLOGY 161:193-206(2010).
Lo Vasco, VR; Fabrizi, C; et al. Expression of phosphoinositide-specific phospholipase C isoenzymes in cultured astrocytes. JOURNAL OF CELLULAR BIOCHEMISTRY 100:952-959(2007).
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