Description : |
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. |
Source : |
Mammalian cells |
Species : |
Human |
Tag : |
Flag |
Form : |
25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Molecular Mass : |
138.4 kDa |
AA Sequence : |
MAGAQPGVHALQLKPVCVSDSLKKG TKFVKWDDDSTIVTPIILRTDPQGF FFYWTDQNKETELLDLSLVK DARCGRHAKAPKDPKLRELLDVGNI GRLEQRMITVVYGPDLVNISHLNLV AFQEEVAKEWTNEVFSLATN LLAQNMSRDAFLEKAYTKLKLQVTP EGRIPLKNIYRLFSADRKRVETALE ACSLPSSRNDSIPQEDFTPE VYRVFLNNLCPRPEIDNIFSEFGAK SKPYLTVDQMMDFINLKQRDPRLNE ILYPPLKQEQVQVLIEKYEP NNSLARKGQISVDGFMRYLSGEENG VVSPEKLDLNEDMSQPLSHYFINSS HNTYLTAGQLAGNSSVEMYR QVLLSGCRCVELDCWKGRTAEEEPV ITHGFTMTTEISFKEVIEAIAECAF KTSPFPILLSFENHVDSPKQ QAKMAEYCRLIFGDALLMEPLEKYP LESGVPLPSPMDLMYKILVKNKKKS HKSSEGSGKKKLSEQASNTY SDSSSMFEPSSPGAGEADTESDDDD DDDDCKKSSMDEGTAGSEAMATEEM SNLVNYIQPVKFESFEISKK RNKSFEMSSFVETKGLEQLTKSPVE FVEYNKMQLSRIYPKGTRVDSSNYM PQLFWNAGCQMVALNFQTMD LAMQINMGMYEYNGKSGYRLKPEFM RRPDKHFDPFTEGIVDGIVANTLSV KIISGQFLSDKKVGTYVEVD MFGLPVDTRRKAFKTKTSQGNAVNP VWEEEPIVFKKVVLPTLACLRIAVY EEGGKFIGHRILPVQAIRPG YHYICLRNERNQPLTLPAVFVYIEV KDYVPDTYADVIEALSNPIRYVNLM EQRAKQLAALTLEDEEEVKK EADPGETPSEAPSEARTTPAENGVN HTTTLTPKPPSQALHSQPAPGSVKA PAKTEDLIQSVLTEVEAQTI EELKQQKSFVKLQKKHYKEMKDLVK RHHKKTTDLIKEHTTKYNEIQNDYL RRRAALEKSAKKDSKKKSEP SSPDHGSSTIEQDLAALDAEMTQKL IDLKDKQQQQLLNLRQEQYYSEKYQ KREHIKLLIQKLTDVAEECQ NNQLKKLKEICEKEKKELKKKMDKK RQEKITEAKSKDKSQMEEEKTEMIR SYIQEVVQYIKRLEEAQSKR QEKLVEKHKEIRQQILDEKPKLQVE LEQEYQDKFKRLPLEILEFVQEAMK GKISEDSNHGSAPLSLSSDP GKVNHKTPSSEELGGDIPGKEFDTP L TRTRPLEQKLISEEDLAANDILDYK DDDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining. |
Stability : |
Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : |
Store at -80 centigrade. |
Concentration : |
>50 ug/mL as determined by microplate BCA method. |
Preparation : |
Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
Protein Families : |
Druggable Genome |
Protein Pathways : |
Alzheimer's disease, Calcium signaling pathway, Chemokine signaling pathway, Gap junction, GnRH signaling pathway, Huntington's disease, Inositol phosphate metabolism, Long-term depression, Long-term potentiation, Melanogenesis, Metabolic pathways, Phosphatidylinositol signaling system, Vascular smooth muscle contraction, Wnt signaling pathway |