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POU2F3

  • Official Full Name

    POU class 2 homeobox 3

  • Overview

    This gene encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
  • Synonyms

    POU2F3; POU class 2 homeobox 3; POU domain class 2, transcription factor 3; POU domain, class 2, transcription factor 3; Epoc 1; OCT11; PLA 1; Skn 1a; Epoc1; HGNC19864; Oct 11; Octamer binding transcription factor 11; PLA1 protein; POU domain; POU transcription factor; Transcription factor Skn1; OTTHUMP00000231987; OTTHUMP00000231988; octamer-binding protein 11; transcription factor PLA-1; transcription factor Skn-1; POU domain transcription factor OCT11a; octamer-binding transcription factor 11; PLA1; PLA-1; Epoc-1; OCT-11; OTF-11; Skn-1a;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human POU2F3-3002HCL Recombinant Human POU2F3 293 Cell Lysate HEK293 N/A
Human POU2F3-6682H Recombinant Human POU2F3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human POU2F3-981HFL Recombinant Full Length Human POU2F3 Protein, C-Flag-tagged Mammalian cells Flag
Human POU2F3-1738H-B Recombinant Human POU2F3 Protein Pre-coupled Magnetic Beads HEK293
Human POU2F3-1738H Recombinant Human POU2F3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Pou2f3-5019M Recombinant Mouse Pou2f3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Zebrafish POU2F3-4258Z Recombinant Zebrafish POU2F3 Mammalian Cell His
Zebrafish POU2F3-7864Z Recombinant Zebrafish POU2F3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

POU2F3 involved in several pathways and played different roles in them. We selected most pathways POU2F3 participated on our site, such as Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with POU2F3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Herpes simplex infectionPER1;IRF3;IRF9;MED8;FASLG;TAF13;C3A.1;CYCSB;RNASEL

POU2F3 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, protein binding, protein dimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by POU2F3 itself. We selected most functions POU2F3 had, and list some proteins which have the same functions with POU2F3. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA bindingSOX10;AKNA;PAX8;PITX1;HAND1;EP300;ZNF502;GABPA;MITFA
protein bindingPOP7;RAB10;GEM;NR2F6;PKMYT1;PRAP1;TEX10;C17orf82;ZNF398
protein dimerization activityZBED6;SCXB;EBF4;TCF21;MYO5A;OLIG4;HER15.1;ASCL2;POU2F3
sequence-specific DNA bindingFOXP4;NKX3.2;DBX1A;NR1H4;SPDEF;NR2F2;NKX2.7;FOXO3A;HNF4G
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingMEIS3;LEF1;NOBOX;ELF4;NFAT5;RBPJ;NFIB;ONECUTL;STAT3

POU2F3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POU2F3 here. Most of them are supplied by our site. Hope this information will be useful for your research of POU2F3.

BCL6

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