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PSEN2

  • Official Full Name

    presenilin 2 (Alzheimer disease 4)

  • Overview

    Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor such that, they either directly regulate gamma-secretase activity, or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified.
  • Synonyms

    PSEN2; AD4; PS2; AD3L; AD3LP; STM2; CMD1V; presenilin 2 (Alzheimer disease 4); presenilin 2; presenilin-2; AD5; E5-1; PS-2; STM-2; OTTHUMP00000035671; OTTHUMP00000035672; OTTHUMP00000228286; OTTHUMP00000228288; EC 3.4.23.-; EC 3.4.23; PSNL2;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Wheat Germ
  • C
  • Myc
  • DDK
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
  • GST
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PSEN2-28527TH Recombinant Human PSEN2 Wheat Germ N/A 86 amino acids
Human PSEN2-HCL Recombinant Human PSEN2 Over expression Lysate, C-Myc/DDK-tagged HEK293T C-Myc/DDK
Human PSEN2-12H Recombinant Human PSEN2 Protein(1-87 aa), GST-tagged E.coli N-GST 1-87 aa
Rat PSEN2-4759R Recombinant Rat PSEN2 Protein Mammalian Cell His
Rat PSEN2-4418R Recombinant Rat PSEN2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PSEN2-4418R-B Recombinant Rat PSEN2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PSEN2-3644R Recombinant Rhesus monkey PSEN2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PSEN2-3462R Recombinant Rhesus Macaque PSEN2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PSEN2-3462R-B Recombinant Rhesus Macaque PSEN2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PSEN2-9063Z Recombinant Zebrafish PSEN2 Mammalian Cell His
Chicken PSEN2-5875C Recombinant Chicken PSEN2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PSEN2 Related Research Area
  • PSEN2 Related Signal Pathway

PSEN2 involved in several pathways and played different roles in them. We selected most pathways PSEN2 participated on our site, such as Notch signaling pathway, Neurotrophin signaling pathway, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSEN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Notch signaling pathwayNOTCH2;NOTCH4;EP300;CTBP1;DTX3L;NOTCH1B;MYCBP;KAT2A;DLA
Neurotrophin signaling pathwayMAPK12;PIK3CB;BDNF;AKT2;CALML3;CALM2;SH2B3;CAMK2D;PIK3R2
Alzheimers diseaseATP5C1;NDUFA8;ATP2A3;NDUFA10;PLCB3;MAPK3;NDUFS5;COX4I1;CALML3

PSEN2 has several biochemical functions, for example, aspartic-type endopeptidase activity, endopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSEN2 itself. We selected most functions PSEN2 had, and list some proteins which have the same functions with PSEN2. You can find most of the proteins on our site.

Function Related Protein
aspartic-type endopeptidase activityPIP;PGA;PGA5;SPPL3;REN2;DDI1;ANK2B;Ren1;Casp3
endopeptidase activitySENP3;PSMB8;PSMB8F;PCSK6;CPNE1;NAPSA;KLK1B26;F9;PSMB2
protein bindingSPSB1;HER5;OCIAD1;ARAP3;AK8;RNF20;AP1M2;PRKD3;INO80B

PSEN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSEN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSEN2.

FHL2; CIB1; UBQLN1; SRI; BCL2L1; ECSIT; FLNB

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