PTPN21
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Official Full Name
protein tyrosine phosphatase, non-receptor type 21
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Overview
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis. [provided by RefSeq, Jul 2008] -
Synonyms
PTPN21; protein tyrosine phosphatase, non-receptor type 21; PTPD1; PTPRL10; tyrosine-protein phosphatase non-receptor type 21; protein tyrosine phosphatase D1; protein-tyrosine phosphatase D1; dJ1175B15.2 (protein tyrosine phosphatase, non-receptor type 21);
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- Myc|DDK
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | PTPN21-8101H | Recombinant Human PTPN21 protein, His & T7-tagged | E.coli | His/T7 | Phe981~Ile1174 (Accession # Q16825) |
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| Human | PTPN21-3130H | Recombinant Human PTPN21 Protein, MYC/DDK-tagged | HEK293 | Myc/DDK |
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| Mouse | Ptpn21-8102M | Recombinant Mouse Ptpn21 protein, His & T7-tagged | E.coli | His/T7 | Phe983~Ile1176 (Accession # G5E8J4) |
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| Mouse | Ptpn21-5240M | Recombinant Mouse Ptpn21 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Rat | PTPN21-4833R | Recombinant Rat PTPN21 Protein | Mammalian Cell | His |
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| Rat | PTPN21-4492R | Recombinant Rat PTPN21 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Rat | PTPN21-4492R-B | Recombinant Rat PTPN21 Protein Pre-coupled Magnetic Beads | HEK293 |
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PTPN21 involved in several pathways and played different roles in them. We selected most pathways PTPN21 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPN21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
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PTPN21 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by PTPN21 itself. We selected most functions PTPN21 had, and list some proteins which have the same functions with PTPN21. You can find most of the proteins on our site.
| Function | Related Protein |
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PTPN21 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPN21 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPN21.
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