Recombinant Human PTPN21 Protein, MYC/DDK-tagged

• Cat.No.: PTPN21-3130H
• Product Overview: Recombinant Human PTPN21 protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.

Specification

• Description: The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis.
• Source: HEK293
• Species: Human
• Tag: MYC/DDK
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 133.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: PTPN21 protein tyrosine phosphatase, non-receptor type 21 [ Homo sapiens ]
• Official Symbol: PTPN21
• Synonyms: PTPD1; PTPRL10
• Gene ID: 11099
• mRNA Refseq: NM_007039
• Protein Refseq: NP_008970
• MIM: 603271
• UniProt ID: Q16825