ULK1
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Official Full Name
unc-51-like kinase 1
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Overview
Two related serine/threonine kinases, UNC-51-like kinase 1 and 2 (ULK1, ULK2), were discovered as mammalian homologs of the C. elegans gene UNC-51 in which mutants exhibited abnormal axonal extension and growth. Both proteins are widely expressed and cont -
Synonyms
ULK1; unc-51-like kinase 1 (C. elegans); unc 51 (C. elegans) like kinase 1; serine/threonine-protein kinase ULK1; ATG1; ATG1 autophagy related 1 homolog (S. cerevisiae); ATG1A; ATG1 autophagy related 1 homolog; autophagy-related protein 1 homolog; UNC51;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Human
- Mouse
- Free Style 293-F Cell
- HEK293
- HEK293T
- Insect cells
- Mammalian Cell
- Mammalian cells
- Sf21
- Sf9 Insect Cell
- Sf9 Insect Cells
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
- 6×His
- C
- Strep II
- Involved Pathway
- Protein Function
- Interacting Protein
- ULK1 Related Articles
ULK1 involved in several pathways and played different roles in them. We selected most pathways ULK1 participated on our site, such as Regulation of autophagy, mTOR signaling pathway, AMPK signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ULK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Regulation of autophagy | IFNA6;PRKAA1;ATG4D;ATG4B;ULK3;ATG4A;ATG7;INSB;Ifna15 |
mTOR signaling pathway | EIF4E2RS1;PIK3R3B;RPTOR;INS1;RPS6KB2;AKT1;RPS6KA3B;VEGFAB;PIK3CG |
AMPK signaling pathway | PRKAB2;IRS2;PRKAG1;FBP2;PPP2R5D;CD36;RAB2A;EEF2;CREB3L3 |
ULK1 has several biochemical functions, for example, ATP binding, Rab GTPase binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ULK1 itself. We selected most functions ULK1 had, and list some proteins which have the same functions with ULK1. You can find most of the proteins on our site.
Function | Related Protein |
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ATP binding | DDR2;YRK;MYH7;KITA;NEK6;MAP4K1;STK17A;GTF2F2;CAMK1GB |
Rab GTPase binding | HPS6;EHD1;RAB11FIP4B;SYTL1;LLGL1;UNC13D;RILP;MLPH;RAB3GAP2 |
protein binding | NUDT4;DISC1;ERCC8;USP2;ITSN2;FGFR1;ZNF230;CYTIP;KLF2 |
protein complex binding | RBX1;CCNE1;ANKRD32;NCK2;TMED10;LRP2;PFKP;BRK1;GRIN2A |
protein serine/threonine kinase activity | ACVR1L;IRAK3;DAPK2;DCAMKL2;CDK12;DCKL1B;PRPF4B;BMP2K;SLC14A2 |
ULK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ULK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ULK1.
RB1CC1; GABARAP; GABARAPL2; ATG13; MAP1LC3C; MAP1LC3B; GABARAPL1
- Q&As
- Reviews
Q&As (7)
Ask a questionULK1 interacts with several autophagy-related proteins, including ATG13, FIP200, and ATG101, forming a complex that is essential for the initiation of autophagy.
mTOR (mechanistic target of rapamycin) is a known upstream regulator of ULK1. When nutrients are abundant, mTOR is active and inhibits ULK1. Conversely, under nutrient starvation, mTOR is inactivated, leading to ULK1 activation and initiation of autophagy.
ULK1 is a serine/threonine-protein kinase that plays a crucial role in the initiation of autophagy, a cellular process responsible for the degradation and recycling of cellular components.
Dysregulation of ULK1 can lead to impaired autophagy, which has been implicated in several diseases, including cancer. Overactive or underactive ULK1 can disrupt cellular homeostasis and contribute to tumorigenesis.
ULK1 undergoes several post-translational modifications, including phosphorylation and ubiquitination, which can either activate or inhibit its kinase activity and, consequently, its role in autophagy.
ULK1 is part of a complex that is essential for the initiation of autophagy. Upon activation, ULK1 phosphorylates several targets, leading to the nucleation and formation of the autophagosome.
ULK1 activity is sensitive to nutrient availability. Under nutrient-rich conditions, ULK1 is inhibited, while under nutrient-deprived conditions, ULK1 becomes activated, promoting autophagy to recycle cellular components and generate energy.
Customer Reviews (3)
Write a reviewReliable results, will reorder.
Affordable and high-quality.
Met all my expectations.
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