AMBRA1A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Zebrafish | AMBRA1A-8356Z | Recombinant Zebrafish AMBRA1A | Mammalian Cell | His |
|
- Involved Pathway
- Protein Function
- Interacting Protein
AMBRA1A involved in several pathways and played different roles in them. We selected most pathways AMBRA1A participated on our site, such as Cellular responses to stress, Macroautophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with AMBRA1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cellular responses to stress | RBBP4;HSBP1A;ASF1A;EHMT2;BMI1A;HIST1H1E;H3F3D;EP400;ACD |
| Macroautophagy | ATG4A;LC3;WIPI2;UVRAG;MAP1LC3B;RB1CC1;ATG101;ULK1A;WDR45 |
AMBRA1A has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by AMBRA1A itself. We selected most functions AMBRA1A had, and list some proteins which have the same functions with AMBRA1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
AMBRA1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AMBRA1A here. Most of them are supplied by our site. Hope this information will be useful for your research of AMBRA1A.
- Q&As
- Reviews
Q&As (10)
Ask a questionAMBRA1A interacts with ATG proteins and Beclin 1 to form protein complexes that regulate autophagy initiation and autophagosome formation.
AMBRA1A targets specific cargoes for degradation via autophagy, including protein aggregates, damaged organelles, and intracellular pathogens.
Targeting AMBRA1A in autophagy-related diseases holds therapeutic potential, as modulating its activity may restore autophagic flux and mitigate pathological processes in cancer and neurodegenerative disorders.
AMBRA1A knockout leads to embryonic lethality and disrupted tissue homeostasis, highlighting its crucial role in development and cellular maintenance.
AMBRA1A plays a critical role in autophagosome formation and turnover by coordinating the nucleation, elongation, and closure steps of autophagy.
AMBRA1A is involved in neuronal autophagy, and dysregulation of its function is implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's.
AMBRA1A regulates downstream effectors and signaling pathways, such as mTORC1 and AMPK, to control autophagy induction and cellular responses to stress.
Post-translational modifications of AMBRA1A, like phosphorylation or ubiquitination, modulate its activity and interactions with other autophagy-related proteins.
The structural domains of AMBRA1A, including its WD40 repeats and coiled-coil domains, mediate interactions with other proteins in the autophagy machinery.
AMBRA1A maintains the balance between autophagy and apoptosis, contributing to cell survival or cell death decisions under various stress conditions.
Customer Reviews (3)
Write a reviewEnhanced multiplexing capability for simultaneous analysis of multiple proteins.
Compatibility with various cell culture systems for functional studies.
Accurate determination of protein-protein interaction stoichiometry.
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