DHDH
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Official Full Name
dihydrodiol dehydrogenase (dimeric)
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Overview
This gene encodes an enzyme that belongs to the family of dihydrodiol dehydrogenases, which exist in multiple forms in mammalian tissues and are involved in the metabolism of xenobiotics and sugars. These enzymes catalyze the NADP1-linked oxidation of transdihydrodiols of aromatic hydrocarbons to corresponding catechols. This enzyme is a dimeric dihydrodiol dehydrogenase, and it differs from monomeric dihydrodiol dehydrogenases in its high substrate specificity for trans-dihydrodiols of aromatic hydrocarbons in the oxidative direction. -
Synonyms
DHDH; dihydrodiol dehydrogenase (dimeric); trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; HUM2DD; D-xylose 1-dehydrogenase; 3-deoxyglucosone reductase; D-xylose-NADP dehydrogenase; 2DD;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus Monkey
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- Fc
- Avi
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
DHDH involved in several pathways and played different roles in them. We selected most pathways DHDH participated on our site, such as Pentose and glucuronate interconversions, Metabolism of xenobiotics by cytochrome P, which may be useful for your reference. Also, other proteins which involved in the same pathway with DHDH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Pentose and glucuronate interconversions | XYLB;UGT1A9;GKUP;UGP2B;UGT2A2;ALDH1B1;UGT1A6B;SORD;UGDH |
Metabolism of xenobiotics by cytochrome P | CYP2F2;MGST2;AKR7A3;GSTA3;ALDH3A1;UGT1A6B;UGT5G1;AKR7A5;UGT2A3 |
DHDH has several biochemical functions, for example, D-xylose 1-dehydrogenase (NADP+) activity, NAD(P)+ transhydrogenase activity, electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DHDH itself. We selected most functions DHDH had, and list some proteins which have the same functions with DHDH. You can find most of the proteins on our site.
Function | Related Protein |
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D-xylose 1-dehydrogenase (NADP+) activity | DHDH;DHDHL |
NAD(P)+ transhydrogenase activity | DHDH;NNT |
electron carrier activity | DERL3;ACAD11;AKR1C4;ALDH2;SDHD;ACOX1;AOX3L1;SRD5A1;DHRS3 |
trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity | DHDH;AKR1C21;AKR1C3;AKR1C2 |
DHDH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHDH here. Most of them are supplied by our site. Hope this information will be useful for your research of DHDH.
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