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DHX9

Official Full Name

DEAH (Asp-Glu-Ala-His) box polypeptide 9
Overview

This gene encodes a member of the DEAH-containing family of RNA helicases. The encoded protein is an enzyme that catalyzes the ATP-dependent unwinding of double-stranded RNA and DNA-RNA complexes. This protein localizes to both the nucleus and the cytoplasm and functions as a transcriptional regulator. This protein may also be involved in the expression and nuclear export of retroviral RNAs. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 11 and 13.
Synonyms

DHX9; DEAH (Asp-Glu-Ala-His) box polypeptide 9; DDX9, DEAD/H (Asp Glu Ala Asp/His) box polypeptide 9 (RNA helicase A, nuclear DNA helicase II; leukophysin) , LKP; ATP-dependent RNA helicase A; NDH II; RHA; leukophysin; DEAH box protein 9; nuclear DNA hel;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque
Zebrafish

Source

E.coli
E.Coli or Yeast
HEK293
Mammalian Cell
Wheat Germ

Tag

Flag
Myc
GST
His
Fc
Avi
SUMO
Non

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	DHX9-32H	Recombinant Human DHX9 protein, His/SUMO-tagged	E.coli	His&SUMO		Inquiry
Human	DHX9-630H	Recombinant Human DHX9 protein, Flag-Myc-tagged	HEK293	Flag&Myc	325-840aa	Inquiry
Human	DHX9-30765TH	Recombinant Human DHX9	Wheat Germ	Non	90 amino acids	Inquiry
Human	DHX9-631H	Recombinant Human DHX9 protein, GST-tagged	Wheat Germ	GST	1 a.a. - 90 a.a.	Inquiry
Human	DHX9-33H	Recombinant Human DHX9 protein, His-tagged	E.coli	His	325-840aa	Inquiry
Human	APOA1-699H	Recombinant Human APOA1 protein	E.coli	Non	Arg19-Gln267	Inquiry
Mouse	DHX9-4586M	Recombinant Mouse DHX9 Protein	Mammalian Cell	His		Inquiry
Mouse	Dhx9-3749M	Recombinant Mouse Dhx9, His-tagged	E.Coli or Yeast	His	1383	Inquiry
Mouse	DHX9-2372M	Recombinant Mouse DHX9 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Mouse	DHX9-2372M-B	Recombinant Mouse DHX9 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	DHX9-1264R	Recombinant Rhesus monkey DHX9 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	DHX9-1089R-B	Recombinant Rhesus Macaque DHX9 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rhesus Macaque	DHX9-1089R	Recombinant Rhesus Macaque DHX9 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Zebrafish	DHX9-7932Z	Recombinant Zebrafish DHX9	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

DHX9 involved in several pathways and played different roles in them. We selected most pathways DHX9 participated on our site, such as Activated TLR4 signalling, Cytosolic sensors of pathogen-associated DNA, DEx/H-box helicases activate type I IFN and inflammatory cytokines production, which may be useful for your reference. Also, other proteins which involved in the same pathway with DHX9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Activated TLR4 signalling	TAB1;TNIP2;APPB;MAPK14;TANK;MAP3K8;ATF2;RIPK3;UBE2V1
Cytosolic sensors of pathogen-associated DNA	NLRP4;AGER;S100A12;DDX41;NLRP4E;TICAM1;CHST13;POLR3C;APPB
DEx/H-box helicases activate type I IFN and inflammatory cytokines production	ALCAMB;CHST13;S100B;S100A12;APPB;DHX9;AGER;APPA;SAA1
Gene Expression	ZNF625;LCMT2;HNRNPA0;HNRNPL;ZNF559;CSTF3;SNAPC4;HIPK1;ZNF726
Immune System	IFIT11;FBXO44;DCTN3;IRF6;STIM1B;TPP2;LAIR2;HECTD3;KLRB1A
Innate Immune System	LGALS3;CTSK;NLRC5;DEFA1;DEFB4B;KIR3DS1;NCKAP1;ABI1;PLD4
MyD88 cascade initiated on plasma membrane	TNIP2;TLR10;PELI1;S100B;AGER;PELI3;CHST13;PELI2;ALCAMB
MyD88 dependent cascade initiated on endosome	CHST13;ALCAMB;DHX9;S100A12;S100B

DHX9 has several biochemical functions, for example, ATP binding, ATP-dependent DNA helicase activity, ATP-dependent RNA helicase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DHX9 itself. We selected most functions DHX9 had, and list some proteins which have the same functions with DHX9. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	ACOT12;PAK1;MOCS3;ABCB5;BSK146;TK2;NLRC5;SEPHS2;CLP1
ATP-dependent DNA helicase activity	DDX3X;ERCC2;RUVBL2;GTF2H4;CHST13;DDX11;CHD2;XRCC5;DHX9
ATP-dependent RNA helicase activity	SNRNP200;DDX46;EIF4A1B;TMEM38A;DHX33;DDX50;EIF4A3;DDX10;DDX51
DNA binding	SETDB1;PQBP1;DMRT2B;TBR1B;NR1H5;SP6;ZNF326;SATB1A;PDS5B
RNA helicase activity	UAP1L1;DDX10;RAD54B;PRIM2;DHX16;DHX15;FAM120B;DDX24;CHST13
RNA polymerase II transcription factor binding	DHX9;HCLS1;GATA6;MTDH;GFI1B;SFPI1;ATF4;KDM1A;ID4
poly(A) RNA binding	C1orf35;XRCC6;GRN;RSRC2;RBM6;FAM120A;ETF1B;EIF4G2;HIST1H4E
protein binding	HCST;CD22;DPEP3;SRGAP1;DENR;RPS27L;PAEP;C3orf52;USP46

DHX9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DHX9 here. Most of them are supplied by our site. Hope this information will be useful for your research of DHX9.

NXF1; YBX1; cte_mpmv