Active Native Mouse Thrombin
Cat.No. : | Thrombin-31M |
Product Overview : | Native Mouse Thrombin was purified from Plasma. |
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Description : | Thrombin (EC 3.4.21.5, fibrinogenase, thrombase, thrombofort, topical, thrombin-C, tropostasin, activated blood-coagulation factor II, blood-coagulation factor IIa, factor IIa, E thrombin, beta-thrombin, gamma-thrombin) is a serine protease that in humans is encoded by the F2 gene. Prothrombin (coagulation factor II) is proteolytically cleaved to form thrombin in the coagulation cascade, which ultimately results in the reduction of blood loss. Thrombin in turn acts as a serine protease that converts soluble fibrinogen into insoluble strands of fibrin, as well as catalyzing many other coagulation-related reactions. |
Source : | Plasma |
Species : | Mouse |
Form : | 50% glycerol/water (v/v) |
Bio-activity : | approximately 3800 NIH units/mg |
Molecular Mass : | 36700 Da |
Purity : | >95% by SDS-PAGE |
Storage : | Glyercol formulation: -20°CHepes formulation: -80°C |
Tag : | Non |
Publication : |
A neutralizable dimeric anti-thrombin aptamer with potent anticoagulant activity in mice (2023)
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Gene Name : | F2 coagulation factor II [ Mus musculus ] |
Official Symbol : | F2 |
Synonyms : | F2; coagulation factor II; prothrombin; Cf2; FII; Cf-2; thrombin; |
Gene ID : | 14061 |
mRNA Refseq : | NM_010168 |
Protein Refseq : | NP_034298 |
Pathway : | Blood Clotting Cascade, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Common Pathway, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem; Complement and coagulation cascades, conserved biosystem; |
Function : | calcium ion binding; catalytic activity; hydrolase activity; peptidase activity; protein binding; receptor binding; serine-type endopeptidase activity; serine-type endopeptidase activity; serine-type peptidase activity; thrombospondin receptor activity; |
Products Types
◆ Recombinant Protein | ||
F2-1356R | Recombinant Rhesus Macaque F2 Protein, His (Fc)-Avi-tagged | +Inquiry |
F2-789H | Recombinant Human F2 Protein | +Inquiry |
F2-882H | Recombinant Human F2 Protein, His (Fc)-Avi-tagged | +Inquiry |
F2-955H | Recombinant Human F2 Protein, MYC/DDK-tagged | +Inquiry |
F2-995M | Recombinant Mouse F2 Protein, MYC/DDK-tagged | +Inquiry |
◆ Native Protein | ||
F2-303R | Native Rat Thrombin | +Inquiry |
F2-5287M | Native Mouse Coagulation Factor II | +Inquiry |
Thrombin-61M | Active Native Mouse Thrombin | +Inquiry |
◆ Lysates | ||
F2-2124MCL | Recombinant Mouse F2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewQuality control is evident. This product ensures accuracy in our studies.
Our lab swears by this protein. Fast shipping is a definite bonus.
Consistently reliable. The shipping speed is appreciated in our fast-paced lab.
Q&As (5)
Ask a questionThe F2 gene plays a crucial role in the synthesis of vitamin K-dependent clotting factors, including prothrombin. Disruptions in this process, often due to genetic or nutritional factors, can contribute to coagulation disorders, impacting hemostasis and blood clotting.
Transcriptional regulation of the F2 gene involves factors like vitamin K-dependent gamma-carboxylation. Hepatocytes synthesize prothrombin under the influence of vitamin K and other coagulation factors.
The F2 gene encodes prothrombin, a crucial factor in blood coagulation. Prothrombin is converted to thrombin, a key enzyme in the clotting cascade, facilitating fibrin formation.
Genetic variations in F2, including polymorphisms, can influence prothrombin function. Certain variants may predispose individuals to thrombotic or bleeding disorders.
Genetic variations in the F2 gene can influence prothrombin levels, affecting an individual's propensity for thrombotic events. Certain variants may predispose individuals to a higher or lower risk of abnormal blood clot formation.
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