Recombinant Full Length Rat Pro-Neuregulin-1, Membrane-Bound Isoform(Nrg1) Protein, His-Tagged
Cat.No. : | RFL14495RF |
Product Overview : | Recombinant Full Length Rat Pro-neuregulin-1, membrane-bound isoform(Nrg1) Protein (P43322) (14-662aa), fused to N-terminal His tag, was expressed in E. coli. |
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Source : | E.coli expression system |
Species : | Rattus norvegicus (Rat) |
Tag : | His |
Form : | Lyophilized powder |
Protein length : | Full Length of Mature Protein (14-662) |
AA Sequence : | KKKDRGSRGKPGPAEGDPSPALPPR LKEMKSQESAAGSKLVLRCETSSEY SSLRFKWFKNGNELNRKNKPENIKI QKKPGKSELRINKASLADSGEYMCK VISKLGNDSASANITIVESNEFITG MPASTETAYVSSESPIRISVSTEGA NTSSSTSTSTTGTSHLIKCAEKEKT FCVNGGECFTVKDLSNPSRYLCKCP NEFTGDRCQNYVMASFYMTSRRKRQ ETEKPLERKLDHSLVKESKAEELYQ KRVLTITGICIALLVVGIMCVVAYC KTKKQRQKLHDRLRQSLRSERSNLV NIANGPHHPNPPPENVQLVNQYVSK NVISSEHIVEREVETSFSTSHYTST AHHSTTVTQTPSHSWSNGHTESVIS ESNSVIMMSSVENSRHSSPAGGPRG RLHGLGGPRDNSFLRHARETPDSYR DSPHSERYVSAMTTPARMSPVDFHT PSSPKSPPSEMSPPVSSMTVSMPSV AVSPFVEEERPLLLVTPPRLREKKY DHHPQQLNSFHHNPAHQSTSLPPSP LRIVEDEEYETTQEYESVQEPVKKV TNSRRAKRTKPNGHIANRLEMDSNT SSVSSNSESETEDERVGEDTPFLGI QNPLAASLEVAPAFRLAESRTNPAG RFSTQEELQARLSSVIANQDPIAV |
Purity : | Greater than 90% as determined by SDS-PAGE. |
Applications : | SDS-PAGE |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week. |
Storage : | Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Tris/PBS-based buffer, 6% Trehalose, pH 8.0 |
Reconstitution : | We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference. |
Gene Name : | Nrg1 |
Synonyms : | Nrg1; Ndf; Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1 |
UniProt ID : | P43322 |
Gene Name : | Nrg1 |
Synonyms : | Nrg1; Ndf; Pro-neuregulin-1, membrane-bound isoform; Pro-NRG1 |
UniProt ID : | P43322 |
Products Types
◆ Recombinant Protein | ||
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NRG1-3227H | Recombinant Human NRG1 protein(Ser2-Lys246), Biotinylated | +Inquiry |
NRG1-7321H | Recombinant Human NRG1 protein(Ser2-Lys246) | +Inquiry |
NRG1-01H | Active Recombinant Human NRG1 Protein, His-tagged | +Inquiry |
NRG1-10H | Recombinant Human NRG1 protein(Ser20-Lys241), hFc-tagged | +Inquiry |
◆ Lysates | ||
NRG1-1592HCL | Recombinant Human NRG1 cell lysate | +Inquiry |
NRG1-1591HCL | Recombinant Human NRG1 cell lysate | +Inquiry |
NRG1-001CCL | Recombinant Canine NRG1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewExcellent results, very consistent.
Worked great in assays.
Great product, very reliable.
Q&As (7)
Ask a questionNRG1 is essential for neural development, influencing neuronal migration, myelination, and synapse formation. It also plays a role in synaptic plasticity, modulating neurotransmission and synaptic strength.
In the heart, NRG1 is involved in the regulation of cardiac development, including trabeculation. It also has protective effects on cardiac muscle cells and can influence heart repair mechanisms.
Dysregulation of NRG1 signaling has been implicated in several diseases, including schizophrenia, multiple sclerosis, and certain types of cancers. Genetic variations in the NRG1 gene have been associated with increased risk for some of these conditions.
Given the diverse roles of NRG1 in various physiological processes, it presents as a potential therapeutic target. For instance, recombinant NRG1 has been explored for heart failure treatment, and its modulation is being studied in the context of neural disorders and cancers.
Yes, there are multiple isoforms of NRG1, generated through alternative splicing. These isoforms can differ in their tissue distribution, receptor binding, and functional roles.
NRG1 primarily interacts with the ErbB family of tyrosine kinase receptors, especially ErbB3 and ErbB4. Upon binding, it activates downstream pathways such as the PI3K/Akt and MAPK pathways.
NRG1 is a versatile signaling molecule that plays crucial roles in the development and function of multiple organ systems, including the nervous system, heart, and breast.
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