Recombinant Human CSF3R Protein, His-tagged

• Cat.No.: CSF3R-259H
• Product Overview: Recombinant human CSF3R protein with His tag was expressed in HEK293.

Specification

• Description: The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Alternatively spliced transcript variants have been described. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia.
• Source: HEK293
• Species: Human
• Tag: His
• Form: Lyophilized
• Molecular Mass: 69 kDa
• Protein length: 836
• AA Sequence: MARLGNCSLTWAALIILLLPGSLEE CGHISVSAPIVHLGDPITASCIIKQ NCSHLDPEPQILWRLGAELQPGGRQ QRLSDGTQESIITLPHLNHTQAFLS CCLNWGNSLQILDQVELRAGYPPAI PHNLSCLMNLTTSSLICQWEPGPET HLPTSFTLKSFKSRGNCQTQGDSIL DCVPKDGQSHCCIPRKHLLLYQNMG IWVQAENALGTSMSPQLCLDPMDVV KLEPPMLRTMDPSPEAAPPQAGCLQ LCWEPWQPGLHINQKCELRHKPQRG EASWALVGPLPLEALQYELCGLLPA TAYTLQIRCIRWPLPGHWSDWSPSL ELRTTERAPTVRLDTWWRQRQLDPR TVQLFWKPVPLEEDSGRIQGYVVSW RPSGQAGAILPLCNTTELSCTFHLP SEAQEVALVAYNSAGTSRPTPVVFS ESRGPALTRLHAMARDPHSLWVGWE PPNPWPQGYVIEWGLGPPSASNSNK TWRMEQNGRATGFLLKENIRPFQLY EIIVTPLYQDTMGPSQHVYAYSQEM APSHAPELHLKHIGKTWAQLEWVPE PPELGKSPLTHYTIFWTNAQNQSFS AILNASSRGFVLHGLEPASLYHIHL MAASQAGATNSTVLTLMTLTPEGSE LHIILGLFGLLLLLTCLCGTAWLCC SPNRKNPLWPSVPDPAHSSLGSWVP TIMEEDAFQLPGLGTPPITKLTVLE EDEKKPVPWESHNSSETCGLPTLVQ TYVLQGDPRAVSTQPQSQSGTSDQV LYGQLLGSPTSPGPGHYLRCDSTQP LLAGLTPSPKSYENLWFQASPLGTL VTPAPSQEDDCVFGPLLNFPLLQGI RVHGMEALGSF
• Purity: > 98%
• Applications: WB; ELISA; FACS; FC
• Stability: This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
• Storage: At -20 centigrade.
• Concentration: 1 mg/mL
• Storage Buffer: PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
• Reconstitution: Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.

Gene Information

• Gene Name: CSF3R colony stimulating factor 3 receptor (granulocyte) [ Homo sapiens (human) ]
• Official Symbol: CSF3R
• Synonyms: CSF3R; colony stimulating factor 3 receptor (granulocyte); CD114; granulocyte colony-stimulating factor receptor; GCSFR; G-CSF-R; CD114 antigen; G-CSF receptor
• Gene ID: 1441
• mRNA Refseq: NM_000760
• Protein Refseq: NP_000751
• MIM: 138971
• UniProt ID: Q99062

Reviews

06/23/2019

the CSF3R protein demonstrates exceptional stability, allowing for prolonged storage and usage without compromising its integrity.

12/07/2018

the protein's high quality ensures accurate and reliable results, enabling precise analysis and interpretation of experimental data.

09/16/2018

The manufacturer of the CSF3R protein plays a crucial role in supporting researchers during their trials.

Q&As

In which conditions are CSF3R-targeted therapies currently being investigated?

CSF3R-targeted therapies are under investigation for conditions such as chronic neutrophilic leukemia and other myeloproliferative neoplasms.

Are there specific diagnostic tests for CSF3R mutations?

Yes, genetic testing and sequencing techniques are commonly employed to identify CSF3R mutations and guide clinical decision-making.

How do CSF3R mutations impact the prognosis of hematological disorders?

The presence and specific type of CSF3R mutations can influence the prognosis of hematological disorders, guiding clinicians in predicting disease progression and response to treatment.

Can CSF3R mutations be hereditary?

Yes, some CSF3R mutations can be hereditary, leading to familial cases of neutropenia.

How does understanding CSF3R protein function contribute to treatment strategies?

Targeted therapies directed at CSF3R may offer more effective and tailored treatment options for patients with disorders related to abnormal granulocyte production.