ccnd1
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  • Official Full Name
  • cyclin D1
  • Background
  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
  • Synonyms
  • CCND1; cyclin D1; BCL1; PRAD1; U21B31; D11S287E; B-cell CLL/lymphoma 1; G1/S-specific cyclin D1; cyclin D1 (PRAD1: parathyroid adenomatosis 1); parathyroid adenomatosis 1; BCL-1 oncogene; PRAD1 oncogene
Cat.#:CCND1-0658HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CCND1 Protein, GST-Tagged
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Cat.#:CDK4/CCND1-633HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human CDK4/CCND1, His-tagged
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Cat.#:CCND1-171HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human CCND1 protein, DDK-tagged
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Cat.#:CCND1-221HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCND1 protein, T7/His-tagged
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Cat.#:CCND1-23HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CCND1 protein, MYC/DDK-tagged
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Cat.#:CCND1-24HTag:flag
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human CCND1 protein, Flag-tagged
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Cat.#:CCND1-27520THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCND1, His-tagged
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Cat.#:CCND1-27756THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCND1
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Cat.#:CCND1-31773THTag:His
Source (Host):Species:Human
Product nameRecombinant Human Human CDK6, His-tagged
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Cat.#:CCND1-354HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCND1 protein, His/MBP-tagged
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Cat.#:CCND1-355HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CCND1 protein, His/MBP-tagged
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Cat.#:IGLC1-14119HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IGLC1, His-tagged
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Cat.#:Ccnd1-2610MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ccnd1 protein, His-tagged
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Cat.#:CCND1-2988MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse CCND1 Protein
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Cat.#:CCND1-1219RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CCND1 Protein
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Cat.#:Ccnd1-2611RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ccnd1 protein, His-tagged
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Cat.#:CCND1-698RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CCND1 Protein, His-tagged
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Cat.#:CCND1-2609CTag:His
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken CCND1 protein, His-tagged
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Cat.#:CCND1-6933CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CCND1
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Cat.#:CCND1-8654ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish CCND1
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Cat.#:CCND1-2608CTag:His/T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle CCND1 protein, His & T7-tagged
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Cat.#:CCND1-1444HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Cyclin D1, GST-tagged
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Cat.#:CCND1-7713HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CCND1 293 Cell Lysate
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CCND1 Related Articles

Tajiri, R; Ooi, A; et al. Intratumoral heterogeneous amplification of ERBB2 and subclonal genetic diversity in gastric cancers revealed by multiple ligation-dependent probe amplification and fluorescence in situ hybridization. HUMAN PATHOLOGY 45:725-734(2014).
Rao, C; Lin, SL; et al. High Expression of IGFBP7 in Fibroblasts Induced by Colorectal Cancer Cells Is Co-Regulated by TGF-beta and Wnt Signaling in a Smad2/3-Dvl2/3-Dependent Manner. PLOS ONE 9:-(2014).