• Official Full Name
  • dopamine beta-hydroxylase (dopamine beta-monooxygenase)
  • Background
  • Dopamine β-hydroxylase (DBH) is an enzyme that converts dopamine to norepinephrine. DBH is a 290 kDa copper-containing oxygenase consisting of four identical subunits, and its activity requires ascorbate as a cofactor. It is the only enzyme involved in the synthesis of small-molecule neurotransmitters that is membrane-bound, making norepinephrine and epinephrine the only transmitters synthesized inside vesicles. It is expressed in noradrenergic nerve terminals of the central and peripheral nervous systems, as well as in chromaffin cells of the adrenal medulla. DBH is inhibited by disulfiram, tropolone, and, most selectively, by nepicastat.
  • Synonyms
  • DBH; dopamine beta-hydroxylase (dopamine beta-monooxygenase); dopamine beta-hydroxylase; DBM
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DBH, GST-tagged
Source (Host):HEK293Species:Human
Product nameRecombinant Human DBH, His tagged
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human DBH
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human DBH
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DBH
Source (Host):HEK293Species:Human
Product nameRecombinant Human DBH cell lysate

DBH Related Articles

Flak, JN; Myers, B; et al. Role of paraventricular nucleus-projecting norepinephrine/epinephrine neurons in acute and chronic stress. EUROPEAN JOURNAL OF NEUROSCIENCE 39:1903-1911(2014).
Lin, LH; Moore, SA; et al. Astrocytes in the Rat Nucleus Tractus Solitarii Are Critical for Cardiovascular Reflex Control. JOURNAL OF NEUROSCIENCE 33:18608-18617(2013).