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DBH

  • Official Full Name

    dopamine beta-hydroxylase (dopamine beta-monooxygenase)

  • Overview

    Dopamine β-hydroxylase (DBH) is an enzyme that converts dopamine to norepinephrine. DBH is a 290 kDa copper-containing oxygenase consisting of four identical subunits, and its activity requires ascorbate as a cofactor. It is the only enzyme involved in the synthesis of small-molecule neurotransmitters that is membrane-bound, making norepinephrine and epinephrine the only transmitters synthesized inside vesicles. It is expressed in noradrenergic nerve terminals of the central and peripheral nervous systems, as well as in chromaffin cells of the adrenal medulla. DBH is inhibited by disulfiram, tropolone, and, most selectively, by nepicastat.
  • Synonyms

    DBH; dopamine beta-hydroxylase (dopamine beta-monooxygenase); dopamine beta-hydroxylase; DBM;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DBH-929H Recombinant Human DBH Mammalian Cell His
Human DBH-11841H Recombinant Human DBH, GST-tagged E.coli GST C-term-336a.a.
Human DBH-6945H Recombinant Human DBH protein, His & T7-tagged E.coli His/T7 His335~Val571 (Accession # P09172)
Human DBH-26886TH Recombinant Human DBH Wheat Germ N/A 110 amino acids
Human DBH-210H Recombinant Human DBH protein(Ser26-Gly603), His-tagged HEK293 N-His Ser26-Gly603
Human DBH-2366H Recombinant Human DBH Protein, GST-tagged Wheat Germ GST
Human DBH-869HCL Recombinant Human DBH cell lysate Human Cell N/A
Human DBH-4346H Recombinant Human DBH Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DBH-2122H Recombinant Human DBH Protein, His-tagged Yeast His
Human DBH-983H Recombinant Human DBH Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DBH-2799H Recombinant Human DBH protein, His-tagged E.coli His 40-617aa
Human DBH-1923H Recombinant Human DBH Protein (His335-Val571), N-His tagged E.coli N-His His335-Val571
Human DBH-1836HFL Recombinant Full Length Human DBH Protein, C-Flag-tagged Mammalian cells Flag
Human DBH-719H Recombinant Human DBH Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human DBH-719H-B Recombinant Human DBH Protein Pre-coupled Magnetic Beads HEK293
Mouse Dbh-2461M Recombinant Mouse Dbh Protein, Myc/DDK-tagged HEK293T Myc/DDK
Bos taurus (Bovine) RFL5870BF Recombinant Full Length Bovine Dopamine Beta-Hydroxylase(Dbh) Protein, His-Tagged E.coli expression system His Full Length (1-610)
Homo sapiens (Human) RFL36698HF Recombinant Full Length Human Dopamine Beta-Hydroxylase(Dbh) Protein, His-Tagged E.coli expression system His Full Length (1-617)
Zebrafish DBH-6041Z Recombinant Zebrafish DBH Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DBH Related Articles
  • DBH Related Research Area

DBH involved in several pathways and played different roles in them. We selected most pathways DBH participated on our site, such as Amine-derived hormones, Biogenic Amine Synthesis, Catecholamine biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with DBH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Amine-derived hormonesDBH;DIO2;TPH2;DDC;CGA
Biogenic Amine SynthesisDBH;DDC;COMT;CHAT
Catecholamine biosynthesisDBH;MOXD2;DDC
Metabolic pathwaysUGDH;AKR1B10;TPI1A;ATP6V0A4;MINPP1A;SDSL;UCK1;PCK2;NOS2
MetabolismLPA;CETP;ARF3;PPP1R2;TPH2;ACOT6;AK8;PPARGC1B;ADHFE1
Metabolism of amino acids and derivativesSLC25A10;OAZ2;CKMT1B;SLC6A12;SLC6A7;CKMB;NAALAD2;LSM1;SLC25A15
Monoamine TransportSCAMP2;HRH3;TPH2;TGFB1I1;FBXO32;SYN1;DBH;UNC13B
Tyrosine metabolismDBH;AOX3;ALDH1A3;MAOB;COMTA;AOX4;AOX3L1;TAT;GOT2B

DBH has several biochemical functions, for example, L-ascorbic acid binding, catalytic activity, copper ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DBH itself. We selected most functions DBH had, and list some proteins which have the same functions with DBH. You can find most of the proteins on our site.

Function Related Protein
L-ascorbic acid bindingPLOD1A;PAM;P4HA2;EGLN3;DBH;FAM125B;LEPREL1;OGFOD1;EGLN1
catalytic activityCKMT2B;ACSL3A;PPM1AA;MOSC2;ODZ4;ALPI.2;SYN1;APOBEC2A;DBH
copper ion bindingLOXL4;MOXD1;CP;S100U;LOXL1;PRNP;LOXL2A;COMMD1;HAMP
dopamine beta-monooxygenase activity

DBH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DBH here. Most of them are supplied by our site. Hope this information will be useful for your research of DBH.

ITSN1

Flak, JN; Myers, B; et al. Role of paraventricular nucleus-projecting norepinephrine/epinephrine neurons in acute and chronic stress. EUROPEAN JOURNAL OF NEUROSCIENCE 39:1903-1911(2014).
Lin, LH; Moore, SA; et al. Astrocytes in the Rat Nucleus Tractus Solitarii Are Critical for Cardiovascular Reflex Control. JOURNAL OF NEUROSCIENCE 33:18608-18617(2013).
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