DCN
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Official Full Name
decorin
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Overview
The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for this gene. This gene is a candidate gene for Marfan syndrome. [provided by RefSeq, Jul 2008] -
Synonyms
DCN; decorin; CSCD; PG40; PGII; PGS2; DSPG2; SLRR1B; PG-S2; bone proteoglycan II; decorin proteoglycan; proteoglycan core protein; small leucine-rich protein 1B; dermatan sulphate proteoglycans II;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Bovine
- Chicken
- Human
- Mouse
- Rat
- Sheep
- Zebrafish
- CHO
- E.coli
- HEK293
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Sf21 Insect Cell
- Wheat Germ
- Yeast
- C
- His
- Fc
- GST
- His (Fc)
- Avi
- His|SUMO
- Myc
- DDK
- Myc|DDK
- N/A
- N
- hFc
- T7|His
- Involved Pathway
- Protein Function
- Interacting Protein
- DCN Related Articles
DCN involved in several pathways and played different roles in them. We selected most pathways DCN participated on our site, such as A tetrasaccharide linker sequence is required for GAG synthesis, CS/DS degradation, Chondroitin sulfate biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with DCN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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A tetrasaccharide linker sequence is required for GAG synthesis | AGRN;GPC1B;CSPG5;GPC5A;GPC1A;B4GALT7;B3GAT2;VCAN;GPC5 |
CS/DS degradation | CSPG5B;DCN;BGNA;BGN;BCAN;CSPG5;VCANB;NCAN;CSPG4 |
Chondroitin sulfate biosynthesis | BGNA;CSPG5B;VCANB;NCAN;VCAN;DCN;CSPG4;BGN;BCAN |
Chondroitin sulfate/dermatan sulfate metabolism | NCAN;GPC5A;DCN;GPC5;BGNB;CHST14;Gpc2;B3GAT2;B4GALT7 |
Defective B3GALT6 causes EDSP2 and SEMDJL1 | BCAN;GPC6;BGN;AGRN;CSPG5;NCAN;VCAN;DCN;GPC5 |
Defective B3GAT3 causes JDSSDHD | BGN;GPC6;VCAN;GPC5;DCN;AGRN;CSPG4;BCAN;CSPG5 |
Defective B4GALT7 causes EDS, progeroid type | GPC5;NCAN;BCAN;DCN;GPC6;AGRN;VCAN;CSPG5;BGN |
Defective CHST14 causes EDS, musculocontractural type | CSPG5;BGN;DCN;BCAN;CSPG4 |
DCN has several biochemical functions, for example, collagen binding, extracellular matrix binding, glycosaminoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DCN itself. We selected most functions DCN had, and list some proteins which have the same functions with DCN. You can find most of the proteins on our site.
Function | Related Protein |
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collagen binding | CD44;FN1;TGFBI;VWF;SMAD3;C1QTNF1;NID1;SERPINH1B;SPARC |
extracellular matrix binding | BGN;SPOCK2;SPARC;TGFBI;DMP1;CYR61;ITGA2B;FBLN2;SID4 |
glycosaminoglycan binding | ENG;EGFLAM;SERPINE2;SERPINA5;CCDC80;EPYC;BGN;SPOCK2;NDNF |
poly(A) RNA binding | SCAF4;ADARB1;CNBP;MRPL15;NOC4L;LSM8;ETF1;MRPL13;STIP1 |
protein N-terminus binding | TP53;GTF2H3;TAF11;ID1;ERCC4;APTX;PDCD10;PHB2;ZWINT |
DCN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCN here. Most of them are supplied by our site. Hope this information will be useful for your research of DCN.
INS; INS; IGF2; INSR; FGF2; Fgf7; Fgf8; Fgf1
- Q&As
- Reviews
Q&As (7)
Ask a questionTargeted DCN delivery in breast cancer models reduces tumor growth.
DCN modulates TGF-β signaling, affecting fibrosis and cancer development.
Variations in DCN's glycosaminoglycan chains influence its growth factor interactions.
DCN gene silencing in fibroblasts alters extracellular matrix production and cell mobility.
Mechanical forces impact DCN's role in cardiac matrix organization and cell signaling.
Overexpression of DCN changes protein expression related to cell growth and matrix interactions.
DCN bound to collagen reveals binding sites essential for collagen structure.
Customer Reviews (3)
Write a reviewExcellent support for protein purification. Highly recommend this service.
Efficient protein expression, quick turnaround time, and reliable results.
Outstanding antibody validation; trustworthy for protein-protein interaction studies.
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