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DCN

  • Official Full Name

    decorin

  • Overview

    The protein encoded by this gene is a small cellular or pericellular matrix proteoglycan that is closely related in structure to biglycan protein. The encoded protein and biglycan are thought to be the result of a gene duplication. This protein is a component of connective tissue, binds to type I collagen fibrils, and plays a role in matrix assembly. It contains one attached glycosaminoglycan chain. This protein is capable of suppressing the growth of various tumor cell lines. There are multiple alternatively spliced transcript variants known for this gene. This gene is a candidate gene for Marfan syndrome. [provided by RefSeq, Jul 2008]
  • Synonyms

    DCN; decorin; CSCD; PG40; PGII; PGS2; DSPG2; SLRR1B; PG-S2; bone proteoglycan II; decorin proteoglycan; proteoglycan core protein; small leucine-rich protein 1B; dermatan sulphate proteoglycans II;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Chicken
  • Human
  • Mouse
  • Rat
  • Sheep
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Wheat Germ
  • Yeast
  • C
  • His
  • Fc
  • GST
  • His (Fc)
  • Avi
  • His|SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • hFc
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DCN-1702H Active Recombinant Human Decorin, HIgG1 Fc-tagged CHO Fc
Human DCN-2398H Recombinant Human DCN Protein, GST-tagged Wheat Germ GST
Human DCN-82H Recombinant Human DCN protein, T7/His-tagged E.coli T7/His
Human DCN-73H Recombinant Human DCN protein(Asp31-Lys359), hFc-tagged HEK293 N-hFc Asp31-Lys359
Human DCN-1600H Recombinant Human Decorin Sf21 Insect Cell N/A
Human DCN-57H Recombinant Human DCN protein, His-tagged Insect Cell His
Human DCN-3348H Recombinant Human DCN protein HEK293 N/A Met1-Lys359
Human DCN-901H Recombinant Human Decorin, His-tagged E.coli His
Human DCN-2274HCL Recombinant Human DCN cell lysate Human Cell N/A
Human DCN-1170H Recombinant Human DCN Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human DCN-2884HF Recombinant Full Length Human DCN Protein, GST-tagged In Vitro Cell Free System GST 359 amino acids
Human DCN-2804H Recombinant Human DCN protein, His-tagged E.coli His 20-359aa
Human DCN-311H Recombinant Human DCN Protein, His-tagged E.coli His Asp45~Leu152
Human DCN-3358H Recombinant Human DCN protein, His-tagged E.coli His 1-359 aa
Human DCN-356H Recombinant Human DCN Protein (Met1-Lys359) HEK293 N/A Met1-Lys359
Human DCN-1930H Recombinant Human DCN protein(Met1-Lys359), His-tagged HEK293 C-His Met1-Lys359
Human DCN-6518H Recombinant Human DCN Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human DCN-815H Recombinant Human DCN Protein, His-tagged HEK293 His
Human DCN-1929H Recombinant Human DCN Protein (Asp31-Lys359), His tagged E.coli His Asp31-Lys359
Mouse Dcn-1887M Active Recombinant Mouse Dcn protein, His-tagged Mammalian cells His
Mouse DCN-4355M Recombinant Mouse DCN protein, His-tagged HEK293 His Gly17-Lys354
Mouse Dcn-64M Recombinant Mouse Dcn protein, His-tagged Insect Cell His
Mouse Dcn-2475M Recombinant Mouse Dcn Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse DCN-450M Recombinant Mouse DCN Protein (35-354 aa), His-SUMO-tagged E.coli His/SUMO 35-354 aa
Mouse Dcn-2235M-B Recombinant Mouse Dcn Protein Pre-coupled Magnetic Beads HEK293
Mouse Dcn-5639M Recombinant Mouse Dcn Protein (Gly17-Lys354), C-His tagged Mammalian cells C-His Gly17-Lys354
Mouse Dcn-2805M Recombinant Mouse Dcn protein, His-tagged E.coli His 35-354aa
Mouse Dcn-2235M Recombinant Mouse Dcn Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse DCN-1377M Recombinant Mouse DCN Protein (35-354 aa), His-tagged Yeast His 35-354 aa
Rat DCN-1797R Recombinant Rat DCN Protein Mammalian Cell His
Rat DCN-959R Recombinant Rat DCN Protein (Met1-Lys354), His-tagged HEK293 His Met1-Lys354
Rat DCN-1455R-B Recombinant Rat DCN Protein Pre-coupled Magnetic Beads HEK293
Rat DCN-1455R Recombinant Rat DCN Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bovine DCN-5390B Recombinant Bovine DCN protein, His-tagged Yeast His 31-360aa
Sheep DCN-371S Recombinant Sheep DCN protein, His-tagged E.coli His 148aa
Zebrafish DCN-9222Z Recombinant Zebrafish DCN Mammalian Cell His
Chicken DCN-2448C Recombinant Chicken DCN Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DCN Related Articles

DCN involved in several pathways and played different roles in them. We selected most pathways DCN participated on our site, such as A tetrasaccharide linker sequence is required for GAG synthesis, CS/DS degradation, Chondroitin sulfate biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with DCN were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
A tetrasaccharide linker sequence is required for GAG synthesisAGRN;GPC1B;CSPG5;GPC5A;GPC1A;B4GALT7;B3GAT2;VCAN;GPC5
CS/DS degradationCSPG5B;DCN;BGNA;BGN;BCAN;CSPG5;VCANB;NCAN;CSPG4
Chondroitin sulfate biosynthesisBGNA;CSPG5B;VCANB;NCAN;VCAN;DCN;CSPG4;BGN;BCAN
Chondroitin sulfate/dermatan sulfate metabolismNCAN;GPC5A;DCN;GPC5;BGNB;CHST14;Gpc2;B3GAT2;B4GALT7
Defective B3GALT6 causes EDSP2 and SEMDJL1BCAN;GPC6;BGN;AGRN;CSPG5;NCAN;VCAN;DCN;GPC5
Defective B3GAT3 causes JDSSDHDBGN;GPC6;VCAN;GPC5;DCN;AGRN;CSPG4;BCAN;CSPG5
Defective B4GALT7 causes EDS, progeroid typeGPC5;NCAN;BCAN;DCN;GPC6;AGRN;VCAN;CSPG5;BGN
Defective CHST14 causes EDS, musculocontractural typeCSPG5;BGN;DCN;BCAN;CSPG4

DCN has several biochemical functions, for example, collagen binding, extracellular matrix binding, glycosaminoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DCN itself. We selected most functions DCN had, and list some proteins which have the same functions with DCN. You can find most of the proteins on our site.

Function Related Protein
collagen bindingCD44;FN1;TGFBI;VWF;SMAD3;C1QTNF1;NID1;SERPINH1B;SPARC
extracellular matrix bindingBGN;SPOCK2;SPARC;TGFBI;DMP1;CYR61;ITGA2B;FBLN2;SID4
glycosaminoglycan bindingENG;EGFLAM;SERPINE2;SERPINA5;CCDC80;EPYC;BGN;SPOCK2;NDNF
poly(A) RNA bindingSCAF4;ADARB1;CNBP;MRPL15;NOC4L;LSM8;ETF1;MRPL13;STIP1
protein N-terminus bindingTP53;GTF2H3;TAF11;ID1;ERCC4;APTX;PDCD10;PHB2;ZWINT

DCN has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCN here. Most of them are supplied by our site. Hope this information will be useful for your research of DCN.

INS; INS; IGF2; INSR; FGF2; Fgf7; Fgf8; Fgf1

Hamodeh, S; Baizer, J; et al. Systematic Analysis of Neuronal Wiring of the Rodent Deep Cerebellar Nuclei Reveals Differences Reflecting Adaptations at the Neuronal Circuit and Internuclear Levels. JOURNAL OF COMPARATIVE NEUROLOGY 522:2481-2497(2014).
Dupuis, LE; Kern, CB; et al. Small Leucine- Rich Proteoglycans Exhibit Unique Spatiotemporal Expression Profiles During Cardiac Valve Development. DEVELOPMENTAL DYNAMICS 243:601-611(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
What is the effect of targeted DCN delivery on tumor growth in a mouse model of breast cancer? 07/10/2022

Targeted DCN delivery in breast cancer models reduces tumor growth.

How does DCN modulate TGF-β signaling at the molecular level? 05/06/2022

DCN modulates TGF-β signaling, affecting fibrosis and cancer development.

How do variations in the glycosaminoglycan chains attached to DCN influence its interaction with growth factors? 12/11/2021

Variations in DCN's glycosaminoglycan chains influence its growth factor interactions.

What are the cellular and molecular consequences of DCN gene silencing in fibroblasts? 12/07/2021

DCN gene silencing in fibroblasts alters extracellular matrix production and cell mobility.

How do mechanical forces influence the function and localization of DCN in the cardiac extracellular matrix? 04/30/2021

Mechanical forces impact DCN's role in cardiac matrix organization and cell signaling.

Which proteins are differentially expressed in cells overexpressing DCN compared to control cells? 10/14/2019

Overexpression of DCN changes protein expression related to cell growth and matrix interactions.

What is the detailed three-dimensional structure of DCN when bound to collagen? 07/27/2018

DCN bound to collagen reveals binding sites essential for collagen structure.

Customer Reviews (3)

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Reviews
03/11/2020

    Excellent support for protein purification. Highly recommend this service.

    11/01/2019

      Efficient protein expression, quick turnaround time, and reliable results.

      10/14/2019

        Outstanding antibody validation; trustworthy for protein-protein interaction studies.

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