Description : |
This gene encodes a member of the small leucine-rich proteoglycan family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protein. This protein plays a role in collagen fibril assembly. Binding of this protein to multiple cell surface receptors mediates its role in tumor suppression, including a stimulatory effect on autophagy and inflammation and an inhibitory effect on angiogenesis and tumorigenesis. This gene and the related gene biglycan are thought to be the result of a gene duplication. Mutations in this gene are associated with congenital stromal corneal dystrophy in human patients. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
39.7 kDa |
AA Sequence : |
MKATIILLLLAQVSWAGPFQQRGLF DFMLEDEASGIGPEVPDDRDFEPSL GPVCPFRCQCHLRVVQCSDLGLDKV PKDLPPDTTLLDLQNNKITEIKDGD FKNLKNLHALILVNNKISKVSPGAF TPLVKLERLYLSKNQLKELPEKMPK TLQELRAHENEITKVRKVTFNGLNQ MIVIELGTNPLKSSGIENGAFQGMK KLSYIRIADTNITSIPQGLPPSLTE LHLDGNKISRVDAASLKGLNNLAKL GLSFNSISAVDNGSLANTPHLRELH LDNNKLTRVPGGLAEHKYIQVVYLH NNNISVVGSSDFCPPGHNTKKASYS GVSLFSNPVQYWEIQPSTFRCVYVR SAIQLGNYKTRTRPLEQKLISEEDL AANDILDYKDDDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |