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DKK1

  • Official Full Name

    dickkopf WNT signaling pathway inhibitor 1

  • Overview

    This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008]
  • Synonyms

    DKK1; dickkopf WNT signaling pathway inhibitor 1; SK; DKK-1; dickkopf-related protein 1; hDkk-1; dickkopf-1 like; dickkopf 1 homolog; dickkopf-like protein 1; dickkopf related protein-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • GMP Proteins
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus
  • Rhesus Macaque
  • CHO
  • CHO-K1
  • E.coli
  • HEK293
  • Hi-5 Insect Cell
  • Human Cell
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Rabbit
  • Sf21 Insect Cell
  • Wheat Germ
  • C
  • hFc
  • His
  • DDK
  • Fc
  • Avi
  • GST
  • His (Fc)
  • His|GST
  • human|IgG1|Fc
  • mFc
  • N/A
  • N
  • 8×His
  • Strep
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human DKK1-386H Active Recombinant Human DKK1, HIgG1 Fc-tagged CHO Fc
Human DKK1-4318H Active Recombinant Human Dickkopf Homolog 1 (Xenopus Laevis) HEK293 N/A
Human DKK1-385H Active Recombinant Human DKK1, MIgG2a Fc-tagged CHO Fc
Human DKK1-1068H Active Recombinant Human DKK1 Sf21 Insect Cell N/A Thr32-His266
Human DKK1-164H Active Recombinant Human DKK1 Protein, Biotinylated Insect Cell N/A Thr32-His266
Human DKK1-1069H Active Recombinant Human DKK1 Protein, Biotinylated Sf21 Insect Cell N/A Thr32-His266
Human DKK1-276H Active Recombinant Human DKK1 protein HEK293 N/A
Human DKK1-1267H Acitve Recombinant Human DKK1 protein(Met2-His266), hFc-tagged HEK293 C-hFc Met2-His266
Human DKK1-01HG Active GMP Recombinant Human DKK1 Protein CHO-K1
Human DKK1-023H Active Recombinant Human DKK1 protein, His-tagged HEK293 His Met 2-His 266
Human DKK1-347H Recombinant Human Dickkopf Homolog 1 (Xenopus laevis), His-tagged Hi-5 Insect Cell His
Human DKK1-32H Recombinant Human DKK1, His tagged Human Cell His
Human DKK1-27614TH Recombinant Human DKK1 N/A
Human DKK1-12010H Recombinant Human DKK1, GST-tagged E.coli GST 32-191a.a.
Human DKK1-229H Recombinant Human DKK1, C13&N15-labeled HEK293 N/A
Human DKK1-27610TH Recombinant Human DKK1, His-tagged His
Human DKK1-198H Recombinant Human DKK1, His-tagged, C13&N15 Labeled HEK293 His
Human DKK1-2663H Recombinant Human DKK1 Protein, GST-tagged Wheat Germ GST
Human DKK1-275H Recombinant Human DKK1 protein, DDK-tagged Insect Cell DDK
Human DKK1-209H Recombinant Human DKK1, His-tagged HEK293 His
Human DKK1-022H Recombinant Human DKK1 protein, His-tagged HEK293 His Thr32-His266
Human DKK1-555H Recombinant Human dickkopf WNT signaling pathway inhibitor 1, His-tagged E.coli His
Human DKK1-277H Recombinant Human DKK1, His-tagged, Biotinylated HEK293 His
Human DKK1-2983HCL Recombinant Human DKK1 cell lysate Human Cell N/A
Human DKK1-145HG Active GMP Recombinant Human DKK1 Protein Insect Cell N/A
Human CAB11524RH Rabbit Anti-Human Dickkopf 1 Homolog Monoclonal Antibody Rabbit N/A
Human DKK1-278H Active Recombinant Human DKK1 protein, Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi Thr32-His266
Human DKK1-313H Recombinant Human DKK1 protein, Fc-tagged HEK293 human/IgG1/Fc 235
Human DKK1-314H Recombinant Human DKK1 protein, Strep-tagged HEK293 Strep 235
Human DKK1-907H Recombinant Human DKK1 protein, His-Avi-tagged HEK293 His-Avi Thr32-His266
Human DKK1-490HB Recombinant Human DKK1 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Thr32-His266
Human DKK1-3944HF Recombinant Full Length Human DKK1 Protein, GST-tagged In Vitro Cell Free System GST 266 amino acids
Human DKK1-195H Recombinant Human DKK1 Protein, Fc-tagged HEK293 Fc 266
Human DKK1-894H Recombinant Human DKK1 Protein, His-tagged CHO N-His Leu33-His266
Human DKK1-194H Recombinant Human DKK1 Protein, His-tagged HEK293 His 266
Human DKK1-430D Active Recombinant Human DKK1 Protein E.coli
Human DKK1-196H Recombinant Human DKK1 Protein, Strep-tagged HEK293 Strep 266
Human DKK1-2060H Recombinant Human DKK1 Protein (Met1-His266), C-His tagged Mammalian cells C-His Met1-His266
Human DKK1-2061H Recombinant Human DKK1 Protein (Thr32-His266), N-His tagged E.coli N-His Thr32-His266
Human DKK1-2062H Recombinant Human DKK1 Protein (Thr32-His266), N-8×His tagged Mammalian cells N-8×His Thr32-His266
Mouse Dkk1-395M Active Recombinant Mouse Dickkopf Homolog 1 (Xenopus laevis), His-tagged Mammalian cells His
Mouse Dkk1-398M Active Recombinant Mouse Dickkopf Homolog 1 (Xenopus laevis) CHO N/A
Mouse Dkk1-985M Active Recombinant Mouse Dkk1 CHO N/A Ser30-His272
Mouse DKK1-4609M Recombinant Mouse DKK1 protein, His-tagged HEK293 His Thr32-His272
Mouse Dkk1-2114M Recombinant Mouse Dickkopf Homolog 1 (Xenopus laevis), His-tagged E.coli His
Mouse Dkk1-2389M-B Recombinant Mouse Dkk1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Dkk1-197M Recombinant Mouse Dkk1 Protein, His-tagged HEK293 His 272
Mouse Dkk1-15M Recombinant Mouse Dkk1 Protein, His-tagged HEK293 His 32-272
Mouse Dkk1-2389M Recombinant Mouse Dkk1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Dkk1-1752M Recombinant Mouse Dkk1 protein, His & GST-tagged E.coli His/GST Val36~Ala260
Mouse Dkk1-293D Active Recombinant Mouse Dkk1 Protein (243 aa) CHO 243
Mouse Dkk1-5641M Recombinant Mouse Dkk1 Protein (Thr32-His272), N-8×His tagged Mammalian cells N-8×His Thr32-His272
Rat Dkk1-831R Recombinant Rat Dkk1 protein, His & GST-tagged E.coli His/GST Val36~Asn260 (Accession # D3Z9J1)
Rat Dkk1-678R Active Recombinant Rat Dkk1 protein(Met1-His270), His-tagged HEK293 C-His Met1-His270
Rat Dkk1-1534R Recombinant Rat Dkk1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Dkk1-1534R-B Recombinant Rat Dkk1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus DKK1-2339R Active Recombinant Rhesus DKK1 protein(Met1-His266,256Asn/Gln), His-tagged HEK293 C-His Met1-His266,256Asn/Gln
Rhesus DKK1-1965R Recombinant Rhesus DKK1 protein, mFc-tagged HEK293 mFc Met1-His266,256Asn/Gln
Rhesus Macaque DKK1-2340R Recombinant Rhesus DKK1, Fc tagged Human Cell Fc
Rhesus Macaque DKK1-1273R Recombinant Rhesus monkey DKK1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque DKK1-2622RCL Recombinant Rhesus DKK1 cell lysate Human Cell N/A
Rhesus Macaque DKK1-1098R-B Recombinant Rhesus Macaque DKK1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque DKK1-1098R Recombinant Rhesus Macaque DKK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • DKK1 Related Articles
  • DKK1 Related Research Area

DKK1 involved in several pathways and played different roles in them. We selected most pathways DKK1 participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DKK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Wnt signaling pathwayCAMK2B1;FZD7A;SFRP1;PPP3CC;GSK3B;CAMK2D;CUL1B;ROCK2;WNT3A

DKK1 has several biochemical functions, for example, co-receptor binding, growth factor activity, low-density lipoprotein particle receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DKK1 itself. We selected most functions DKK1 had, and list some proteins which have the same functions with DKK1. You can find most of the proteins on our site.

Function Related Protein
co-receptor bindingHFE;TFR2;NEO1;DKK1;BMP2;BMP4
growth factor activityHDGFRP3;IGF2B;GFER;IL11;GDF10B;NOV;ANGPTL3;SPAW;FGF9
low-density lipoprotein particle receptor bindingHSP90B1;APOB;APOEA;SACS;CRP;APOA5;SYT1;MMP13;AP2M1
protein bindingASIC1;ZNF473;GOLGA3;NDUFA4;CPEB3;INCENP;BRK1;HSPA2;ARL2
receptor antagonist activityIL18BP;DKK1;ESR2;LRPAP1;ADH7;AGTR2
signal transducer activityTAAR10D;VMN1R43;CNOT7;APOL3;STAT4;OLFR13;ADRA2DA;STAT5B;OMPB

DKK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DKK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DKK1.

MDFI; 386677; LRP6; CORO1A; CTNNB1; SMAD9; DPP4

Jin, HT; Wang, BL; et al. Anti-DKK1 antibody promotes bone fracture healing through activation of beta-catenin signaling. BONE 71:63-75(2015).
Gerbaix, M; Vico, L; et al. Periostin expression contributes to cortical bone loss during unloading. BONE 71:94-100(2015).
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