LGR5
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Official Full Name
leucine-rich repeat containing G protein-coupled receptor 5
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Overview
LGR5 (leucine-rich repeat containing G protein-coupled receptor 5) An Orphan GPCR protein, contains large extracellular domain, Stem cell biomarker for small intestine, active in colon cancer; overexpressed in ovary and liver tumors. -
Synonyms
LGR5; leucine-rich repeat containing G protein-coupled receptor 5; G protein coupled receptor 49 , GPR49, GPR67, leucine rich repeat containing G protein coupled receptor 5; leucine-rich repeat-containing G-protein coupled receptor 5; FEX; HG38; G protein coupled receptor 49; G protein coupled receptor 67; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38; GPR 49; GPR 67; GPR49; GPR67; GRP 49; GRP49; HG 38; Leucine rich repeat containing G protein coupled receptor 5; LGR 5; LGR5_HUMAN; Orphan G protein coupled receptor HG38; OTTHUMP00000241504; OTTHUMP00000241505; OTTHUMP00000241506; orphan G protein-coupled receptor HG38; leucine;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Assay Kits
- Cynomolgus
- Human
- Mouse
- Rat
- CHO
- E. coli
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Mamanlian cells
- Mammalian Cell
- Yeast
- Fc
- Flag
- His
- His (Fc)
- Avi
- His|Myc
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- LGR5 Related Articles
- LGR5 Related Research Area
- LGR5 Related Signal Pathway
LGR5 involved in several pathways and played different roles in them. We selected most pathways LGR5 participated on our site, such as Regulation of FZD by ubiquitination, Signal Transduction, Signaling by Wnt, which may be useful for your reference. Also, other proteins which involved in the same pathway with LGR5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of FZD by ubiquitination | LGR6;RSPO2;LGR5;LGR4;RSPO3;RNF43;FMNL3;RSPO4;ZNRF3 |
| Signal Transduction | GPR31B;KIDINS220B;MKS1;SHRPRBCK1R;OPN4;TAS2R13;SOX9A;ARHGAP36;INTU |
| Signaling by Wnt | USP34;C;RSPO3;TNKS;PRICKLE1;KLHL12;SOX32;CDC73;FMNL3 |
| TCF dependent signaling in response to WNT | KREMEN1;RSPO2;SOX9B;CDC73;SOX13;RNF43;SOX4A;SOX9A;LGR5 |
LGR5 has several biochemical functions, for example, NOT G-protein coupled receptor activity, protein binding, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LGR5 itself. We selected most functions LGR5 had, and list some proteins which have the same functions with LGR5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| NOT G-protein coupled receptor activity | LGR6;SFRP2;SFRP4;SFRP1A;SFRP1;LGR4;SZL;SFRP1B;FRZB |
| protein binding | HRAS;CEP63;MTM1;KIF2A;CALR;TSSC4;BEND5;PIK3R2;CTNNA3 |
| transmembrane signaling receptor activity | CLDN4;DARC;CELSR1;BCAM;TLR18;CD69;BAI2;TLR2-1;OR4D6 |
LGR5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LGR5 here. Most of them are supplied by our site. Hope this information will be useful for your research of LGR5.
pi3p
- Q&As
- Reviews
Q&As (7)
Ask a questionLGR5, a G protein-coupled receptor, is crucial for the maintenance and proliferation of adult stem cells.
Genetic mutations in LGR5 can disrupt normal stem cell function and tissue maintenance.
It plays a key role in promoting tissue regeneration by signaling stem cells to divide and differentiate.
LGR5 acts as a co-receptor in the Wnt signaling pathway, essential for regulating stem cell growth.
Altered LGR5 activity is associated with the growth of certain cancers, particularly colorectal cancer.
LGR5 works alongside Wnt ligands and receptors, enhancing Wnt-mediated signaling in stem cells.
Targeting LGR5 offers potential for both regenerating tissues in degenerative diseases and targeting cancer stem cells.
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