Recombinant Human LGR5 protein, His-Avi-tagged

• Cat.No.: LGR5-549H
• Product Overview: Human LGR5 Protein is expressed from mammalian with His Tag and Avi Tag at the C-terminal. It contains Gly22-Ile560.

Specification

• Description: Lgr5 (leucine-rich repeat G-protein coupled receptor 5), also called GPR49, is a seven-transmembrane glycoprotein receptor in the Lgr family of cell surface receptors. Lgr5 is receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes.
• Source: HEK293
• Species: Human
• Tag: His-Avi
• Form: Supplied as 0.22um filtered solution in PBS (pH 7.4).
• Molecular Mass: The protein has a predicted MW of 63.1 kDa.
• Protein length: Gly22-Ile560
• Endotoxin: Less than 1EU per ug by the LAL method.
• Storage: The product should be stored at -70°C. Please do not repeated freeze-thaw cycles.

Gene Information

• Gene Name: LGR5
• Official Symbol: LGR5
• Synonyms: GRP49; leucine-rich repeat-containing G-protein coupled receptor 5; FEX; G protein-coupled receptor 49; GPR49; GPR49G-protein coupled receptor HG38; GPR67; G-protein coupled receptor 49; G-protein coupled receptor 67; HG38; leucine-rich repeat containing G protein-coupled receptor 5; leucine-rich repeat-containing G protein-coupled receptor 5;Lgr5; MGC117008; orphan G protein-coupled receptor HG38
• Gene ID: 8549
• mRNA Refseq: NM_003667.2
• Protein Refseq: NP_003658.1
• MIM: 606667
• UniProt ID: O75473