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PCM1

  • Official Full Name

    pericentriolar material 1

  • Overview

    The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma.
  • Synonyms

    PCM1; pericentriolar material 1; pericentriolar material 1 protein; PTC4; hPCM-1; PCM-1; PCM1_HUMAN; OTTHUMP00000224566; OTTHUMP00000224569; OTTHUMP00000224570; pericentriolar material 1, PCM1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PCM1-1578H Recombinant Human PCM1, GST-tagged E.coli GST 1-254aa
Human PCM1-30551TH Recombinant Human PCM1 Wheat Germ N/A 530 amino acids
Human PCM1-8022H Recombinant Human PCM1 protein, His & T7-tagged E.coli His/T7 Pro1913~Ile2024 (Accession # Q15154)
Human PCM1-1312HCL Recombinant Human PCM1 cell lysate N/A
Human PCM1-3600H Recombinant Human PCM1 protein, His-tagged E.coli His 1-254 aa
Human PCM1-4812H Recombinant Human PCM1 Protein (Pro1913-Ile2024), N-GST tagged E.coli N-GST Pro1913-Ile2024
Human PCM1-362HF Recombinant Full Length Human PCM1 Protein In Vitro Cell Free System 530 amino acids
Mouse PCM1-12498M Recombinant Mouse PCM1 Protein Mammalian Cell His
Mouse PCM1-6554M Recombinant Mouse PCM1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PCM1-6554M-B Recombinant Mouse PCM1 Protein Pre-coupled Magnetic Beads HEK293
Mouse Pcm1-1927M Recombinant Mouse Pcm1 Protein, His-tagged E.coli N-His Asn30-Arg208
Rat Pcm1-8023R Recombinant Rat Pcm1 protein, His & T7-tagged E.coli His/T7 Gln15~Val210 (Accession # G3V7E6)
Zebrafish PCM1-6543Z Recombinant Zebrafish PCM1 Mammalian Cell His
Chicken PCM1-6100C Recombinant Chicken PCM1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PCM1 involved in several pathways and played different roles in them. We selected most pathways PCM1 participated on our site, such as Anchoring of the basal body to the plasma membrane, Assembly of the primary cilium, Cell Cycle, which may be useful for your reference. Also, other proteins which involved in the same pathway with PCM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Anchoring of the basal body to the plasma membraneDYNC1H1;CCP110;NEK2;IQCB1;SSNA1;OFD1;CEP89;TMEM216;TUBB4A
Assembly of the primary ciliumCP110;CKAP5;BBS5;TNPO1;IFT122;SSTR3;OST4;EXOC3;IFT22
Cell CycleSPO11;SKA2;CEP290;CTDNEP1A;CDC14A;CDC16;CDKN2A;GSK3AA;CDC14AB
Cell Cycle, MitoticCDKN2C;DPF1;CDKN2D;ZWINT;CCDC99;MAPRE1;PIANP;DULLARD;APITD1
Centrosome maturationPCM1;NEDD1;CEP78;TUBG1;MAPRE1;ACTR1A;TUBB4B;CCP110;SSNA1
G2/M TransitionCLASP1;TUBGCP5;CEP78;ACTR1A;LIN37;TUBG2;CEP290;CLASP1A;MAPRE1B
Loss of Nlp from mitotic centrosomesHAUS2;MAPRE1B;MAPRE1;CLASP1A;CENPJ;CEP70;ODF2B;NINL;SSNA1
Loss of proteins required for interphase microtubule organizationfrom the centrosomeNINL;CEP72;DCTN1A;ODF2;CEP135;CEP76;TSGA14;NDE1;CEP57

PCM1 has several biochemical functions, for example, identical protein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PCM1 itself. We selected most functions PCM1 had, and list some proteins which have the same functions with PCM1. You can find most of the proteins on our site.

Function Related Protein
identical protein bindingTPRGL;SMAD1;GRASP;NOL3;TARDBP;AGXT2L2;SLK;FHOD1;MMP9
protein bindingEEF1E1;MED31;UBE2IB;TRAP1;FERD3L;PLEKHF2;SETMAR;GRAP2;NCOA1

PCM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PCM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PCM1.

BBS4; CCDC53

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