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PDK2

  • Official Full Name

    pyruvate dehydrogenase kinase, isozyme 2

  • Overview

    This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
  • Synonyms

    PDK2; pyruvate dehydrogenase kinase, isozyme 2; pyruvate dehydrogenase kinase, isoenzyme 2; PDHK2; pyruvate dehydrogenase, lipoamide, kinase isozyme 2, mitochondrial;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf9 Insect Cell
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PDK2-1071H Active Recombinant Human PDK2, GST-tagged Sf9 Insect Cell GST Full Length
Human PDK2-1620H Recombinant Human PDK2, His-tagged E.coli His 135-407aa
Human PDK2-29162TH Recombinant Human PDK2, His-tagged His 392 amino acids
Human PDK2-651H Recombinant Human PDK2, His-tagged E.coli His
Human PDK2-1071 Recombinant Human PDK2 protein, GST-tagged Insect Cell GST Full Length
Human PDK2-3329HCL Recombinant Human PDK2 293 Cell Lysate HEK293 N/A
Human PDK2-1639H-B Recombinant Human PDK2 Protein Pre-coupled Magnetic Beads HEK293
Human PDK2-1639H Recombinant Human PDK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PDK2-1733HFL Recombinant Full Length Human PDK2 Protein, C-Flag-tagged Mammalian cells Flag
Human PDK2-3199H Recombinant Human PDK2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PDK2-5948HF Active Recombinant Full Length Human PDK2 Protein, GST-tagged Insect (sf21) GST 1-407
Mouse Pdk2-8052M Recombinant Mouse Pdk2 protein, His & T7-tagged E.coli His/T7 Leu155~Trp379 (Accession # Q9JK42)
Mouse PDK2-12584M Recombinant Mouse PDK2 Protein Mammalian Cell His
Mouse Pdk2-4767M Recombinant Mouse Pdk2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PDK2-6608M Recombinant Mouse PDK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PDK2-6608M-B Recombinant Mouse PDK2 Protein Pre-coupled Magnetic Beads HEK293
Rat PDK2-4349R Recombinant Rat PDK2 Protein Mammalian Cell His
Rat PDK2-4009R-B Recombinant Rat PDK2 Protein Pre-coupled Magnetic Beads HEK293
Rat PDK2-4009R Recombinant Rat PDK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PDK2 Related Articles
  • PDK2 Related Research Area

PDK2 involved in several pathways and played different roles in them. We selected most pathways PDK2 participated on our site, such as B Cell Receptor Signaling Pathway, Metabolism, Pyruvate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
B Cell Receptor Signaling PathwayPDK2B;CRKL;ARPC5;TTC6;INPPL1;cgr2b;CD19;CSK;CTNNB2
MetabolismMED9;NAALAD2;ECI1;CYP2K17;CIAPIN1;SIN3B;SULT2ST1;GLIPR1;ALDH9A1A.2
Pyruvate metabolismLDHB;ALDH2.2;PDHA1B;PDK3;ackA;HAGH;MPC1;GLO1;DLDH
Pyruvate metabolism and Citric Acid (TCA) cyclePDP2;PDPR;SLC16A1;D2HGDH;PDK4;PDK3B;MPC1;PDK3;ADHFE1
Regulation of pyruvate dehydrogenase (PDH) complexPDK4;PDK2B;PDK3B;PDK3;PDP2;PDP1;PDK2;PDPR
Signal TransductionSST1.1;RNF31;SOUL3;ARHGEF16;CRABP2B;PTH2;MYO7A;XK;ZFPM2B
Signaling by Retinoic AcidCRABP1A;RARG;ALDH8A1;PDK4;PDK2B;AKR1C6;PDK2;CRABP2A;CRABP2
The citric acid (TCA) cycle and respiratory electron transportNDUFAF6;UCP2;PDK3B;SURF1;BRP44;ETFA;PDPR;NDUFAF7;SLC25A14

PDK2 has several biochemical functions, for example, ATP binding, protein homodimerization activity, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PDK2 itself. We selected most functions PDK2 had, and list some proteins which have the same functions with PDK2. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPDPK1A;EPHA4B;MAP4K1;KCNJ8;CDKL4;TIMM44;HSPH1;PRKACAB;ACVR1C
protein homodimerization activityGDF6;KCNK9;BHLHA15;CEP57;IGJ;UXS1;NR2F2;GNPTG;GSTA4
protein kinase activityDCLK3;MAP2K5;PHKG1B;CCL3;IKBKAP;IKBKB;TNIKB;MAP2K2B;STK38A
pyruvate dehydrogenase (acetyl-transferring) kinase activityPDK2;PDK4;PDK1;PDK3

PDK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PDK2.

HTT; ISOC2; HIC2; VSIG4; Pkd1; CTTN; PDK1; Hdac6

Liu, J; Lu, L; et al. Regulation of The Phosphorylation of Yeast Protein Kinase Sch9 Under Environmental Changes and During Chronological Aging. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 41:192-201(2014).
Seidu, MA; Adams, AR; et al. Immunoreactivity of some epitopes in longtime inappropriately stored paraffin-embedded tissues. JOURNAL OF HISTOTECHNOLOGY 36:59-64(2013).
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