Recombinant Full Length Human PDK2 Protein, C-Flag-tagged

• Cat.No.: PDK2-1733HFL
• Product Overview: Recombinant Full Length Human PDK2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 46 kDa
• AA Sequence: MRWVWALLKNASLAGAPKYIEHFSK FSPSPLSMKQFLDFGSSNACEKTSF TFLRQELPVRLANIMKEINL LPDRVLSTPSVQLVQSWYVQSLLDI MEFLDKDPEDHRTLSQFTDALVTIR NRHNDVVPTMAQGVLEYKDT YGDDPVSNQNIQYFLDRFYLSRISI RMLINQHTLIFDGSTNPAHPKHIGS IDPNCNVSEVVKDAYDMAKL LCDKYYMASPDLEIQEINAANSKQP IHMVYVPSHLYHMLFELFKNAMRAT VESHESSLILPPIKVMVALG EEDLSIKMSDRGGGVPLRKIERLFS YMYSTAPTPQPGTGGTPLAGFGYGL PISRLYAKYFQGDLQLFSME
  GFGTDAVIYLKALSTDSVERLPVYN KSAWRHYQTIQEAGDWCVPSTEPKN TSTYRVSTRTRPLEQKLISEEDLAA NDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protein Kinase

Gene Information

• Gene Name: PDK2 pyruvate dehydrogenase kinase 2 [ Homo sapiens (human) ]
• Official Symbol: PDK2
• Synonyms: PDHK2; PDKII
• Gene ID: 5164
• mRNA Refseq: NM_002611.5
• Protein Refseq: NP_002602.2
• MIM: 602525
• UniProt ID: Q15119