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PLK1

  • Official Full Name

    polo-like kinase 1

  • Overview

    Serine/threonine-protein kinase that performs several important functions throughout M phase of the cell cycle, including the regulation of centrosome maturation and spindle assembly, the removal of cohesins from chromosome arms, the inactivation of APC/C inhibitors, and the regulation of mitotic exit and cytokinesis. Required for recovery after DNA damage checkpoint and entry into mitosis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS.
  • Synonyms

    PLK1; polo-like kinase 1; PLK; STPK13; serine/threonine-protein kinase PLK1; PLK-1; polo like kinase; polo (Drosophia)-like kinase; serine/threonine-protein kinase 13; cell cycle regulated protein kinase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect Cell
  • Insect Cells
  • Mamanlian cells
  • Mammalian Cell
  • Sf21
  • Sf9 Insect Cell
  • C
  • Myc
  • DDK
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PLK1-189H Active Recombinant Human Polo-like Kinase 1 (Drosophila) Insect Cell N/A
Human PLK1-201H Active Recombinant Human PLK1 Protein, N-His-tagged Sf21 His
Human PLK1-785H Active Recombinant Human PLK1 protein, His-tagged Insect Cells His Met1-Ser603
Human PLK1-73H Recombinant Human PLK1 protein, Flag-tagged, Biotinylated Insect Cell Flag
Human PLK1-575H Recombinant Human PLK1 protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PLK1-1085H Recombinant Human Polo-Like Kinase 1, His-tagged Sf9 Insect Cell His
Human PLK1-703HCL Recombinant Human PLK1 cell lysate Insect Cell N/A
Human PLK1-5411HF Active Recombinant Full Length Human PLK1 Protein, DDK-tagged, Biotinylated Insect (sf21) DDK 1-603(end)
Human PLK1-9946HFL Recombinant Full Length Human PLK1 protein, Flag-tagged Mamanlian cells Flag
Human PLK1-352H Recombinant Human PLK1 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human PLK1-7304HF Active Recombinant Full Length Human PLK1 Protein, GST-tagged Insect (sf21) GST 1-603(end)
Human PLK1-3863H Recombinant Human PLK1 protein, His-tagged E.coli His 415-603 aa
Human PLK1-1162H Recombinant Human PLK1 Protein (D371-S603), Tag Free E.coli No tag D371-S603
Human PLK1-4935H Recombinant Human PLK1 Protein (Val415-Ser603), N-His tagged E.coli N-His Val415-Ser603
Human PLK1-1163H Recombinant Human PLK1 Protein (D371-S603), His tagged E.coli His D371-S603
Human PLK133712H Recombinant Human PLK1 (13-345) (T210V) Protein
Human PLK115364H Recombinant Human PLK1 (1-603) Protein
Mouse Plk1-1356M Active Recombinant Mouse Plk1 protein, His-tagged Insect Cells His Met1-Ser603
Mouse PLK1-532MCL Recombinant Mouse PLK1 cell lysate Insect Cell N/A
Mouse Plk1-4936M Recombinant Mouse Plk1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat PLK1-4525R Recombinant Rat PLK1 Protein Mammalian Cell His
Rat PLK1-4185R Recombinant Rat PLK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PLK1-4185R-B Recombinant Rat PLK1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PLK1-1177Z Recombinant Zebrafish PLK1 Mammalian Cell His
Chicken PLK1-2346C Recombinant Chicken PLK1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PLK1 Related Articles
  • PLK1 Related Research Area

PLK1 involved in several pathways and played different roles in them. We selected most pathways PLK1 participated on our site, such as FoxO signaling pathway, Cell cycle, Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
FoxO signaling pathwayINS1;CCND2A;PIK3R3;INS;G6PCA.1;KLF2A;NLK2;STK11;MAPK8A
Cell cycleANAPC2;ANAPC1;ESCO2;NDEL1;POT1A;SKP2;DMC1;CDC20;MASTL
Oocyte meiosisCTH1;MAPK3;MAD2L2;PPP2R5B;CDC23;PPP2R1B;ANAPC7;CAMK2D1;YWHAQB
Progesterone-mediated oocyte maturationRPS6KA3A;CPEB1A;HSP90AB1;RAF1;CDK1;GNAI2;CDC27;PRKACAA;MAPK12A

PLK1 has several biochemical functions, for example, ATP binding, anaphase-promoting complex binding, kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLK1 itself. We selected most functions PLK1 had, and list some proteins which have the same functions with PLK1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingWEE1;NARS2;CCT5;KIF5A;PSMC6;KHK;AGAP2;PI4K2A;MAP4K3
anaphase-promoting complex bindingPTEN;PLK1;CLSPN
kinase activityCMPK;TRIOA;MAP3K12;PRKCDA;GM7168;PKMA;CDC7;STK35L;CDK5R1B
microtubule bindingJAKMIP3;MAPRE3;SYBU;KIF15;APC2;HOOK3;GOLGA2;RGS14;NEFH
protein bindingPKD1L3;MCC;GNAT1;RINL;C1QTNF6;ZKSCAN1;HYI;MED19;SCARF1
protein kinase activityNPRL2;IKBKAP;PTK2;CDK11B;MAPK14B;PRKACAB;TBCK;NEK5;HIPK2
protein kinase bindingSTAT3;USP37;PDCD10;RPS3;PARP1;LIMS1;ZC3HC1;LATS1;AKAP5
protein serine/threonine kinase activityMAPK12B;LMTK2;SMOK3A;SIK2A;PDK3;PKN2;PDPK1;MLKL;Aatk

PLK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLK1.

TP53; SLX4; FADD

Dou, S; Yang, XZ; et al. ScFv-Decorated PEG-PLA-Based Nanoparticles for Enhanced siRNA Delivery to Her2(+) Breast Cancer. ADVANCED HEALTHCARE MATERIALS 3:1792-1803(2014).
van de Waterbeemd, M; Lossl, P; et al. Simultaneous Assessment of Kinetic, Site-Specific, and Structural Aspects of Enzymatic Protein Phosphorylation. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 53:9660-9664(2014).
  • Q&As
  • Reviews

Q&As (5)

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How can PLK1 inhibitors be used in combination with other cancer treatments? 03/16/2023

PLK1 inhibitors can be combined with chemotherapy or radiation therapy to enhance their effectiveness in treating certain types of cancer.

What are the potential clinical applications of PLK1 inhibitors in cancer treatment? 11/24/2019

PLK1 inhibitors are being investigated as potential cancer therapies to target and inhibit the overactive PLK1 in cancer cells.

Are there any specific cancer types where PLK1 inhibitors have shown promise in clinical trials? 08/01/2019

PLK1 inhibitors have shown promise in clinical trials for various cancer types, including breast, lung, and colorectal cancers.

How do researchers target PLK1 specifically in cancer cells without affecting healthy cells? 03/19/2019

This is a significant challenge, and researchers are working on developing selective inhibitors that primarily target cancer cells.

Can PLK1 protein be used as a biomarker for cancer diagnosis? 05/10/2016

PLK1 levels can be elevated in some cancers, and its expression can be used as a diagnostic or prognostic biomarker.

Customer Reviews (3)

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Reviews
09/14/2022

    the manufacturer's dedication to continuous improvement and innovation is evident in their ongoing efforts to enhance the PLK1 protein's performance and optimize its applications.

    02/26/2017

      The exceptional quality and reliability of the PLK1 protein provided by the manufacturer cannot be overstated.

      03/09/2016

        Its purity and consistency guarantee accurate and consistent results, allowing for confident data interpretation and analysis.

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