S100B
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Official Full Name
S100 calcium binding protein B
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Overview
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimers disease, Downs syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008] -
Synonyms
S100B; S100 calcium binding protein B; NEF; S100; S100-B; S100beta; protein S100-B; S-100 protein subunit beta; S-100 calcium-binding protein, beta chain; S100 calcium-binding protein, beta (neural);
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Bovine
- Cattle
- Chicken
- Human
- Mouse
- Rabbit
- Rat
- Rhesus
- Rhesus Macaque
- Zebrafish
- Bovine Brain
- E. coli
- E.coli
- HEK293
- HEK293 cells
- HEK293T
- Human
- Human brain tissue
- Human Cell
- Mammalian Cell
- Mammalian cells
- C
- His
- Myc
- DDK
- Fc
- Flag
- GST
- His (Fc)
- Avi
- His|GST
- His|MBP
- Myc|DDK
- N/A
- N
- hFc
- Involved Pathway
- Protein Function
- Interacting Protein
- S100B Related Articles
- S100B Related Research Area
S100B involved in several pathways and played different roles in them. We selected most pathways S100B participated on our site, such as Activated TLR4 signalling, Advanced glycosylation endproduct receptor signaling, Cytosolic sensors of pathogen-associated DNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with S100B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activated TLR4 signalling | CREB1B;DUSP3;TICAM1;IRAK3;PELI3;TAB1;JUN;CHUK;MAP3K8 |
| Advanced glycosylation endproduct receptor signaling | ALCAMB;DDOST;APPB;LGALS3;S100B;SAA1;AGER;APPA;S100A12 |
| Cytosolic sensors of pathogen-associated DNA | NLRP4B;CHST13;DDX41;POLR3H;LRRFIP1;S100B;POLR3G;POLR3GLA;TRIM56 |
| DEx/H-box helicases activate type I IFN and inflammatory cytokines production | ALCAMB;APPB;DHX9;AGER;S100A12;CHST13;APPA;S100B;SAA1 |
| Immune System | LGALS9;TXNIP;TREML4;BLMH;HUWE1;RAP1GAP2;ACTR1A;HLA-DQB2;LAT2 |
| Innate Immune System | HERC5;DEFA6;CRCP;CFHL3;TRIM56;CNPY3;RNF135;NLRP3;DEFB106A |
| MyD88 cascade initiated on plasma membrane | CHST13;PELI2;TLR10;AGER;DUSP3B;DHX9;S100B;TNIP2;ALCAMB |
| MyD88 dependent cascade initiated on endosome | ALCAMB;S100B;S100A12;DHX9;CHST13 |
S100B has several biochemical functions, for example, RAGE receptor binding, S100 protein binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by S100B itself. We selected most functions S100B had, and list some proteins which have the same functions with S100B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RAGE receptor binding | HMGB1;HMGB2;S100A8;S100A12;FPR1;S100A4;S100B;S100A9;S100P |
| S100 protein binding | EZR;AGER;S100B;S100A11;S100A6;DDX1;FGF1;S100A1;ANXA2 |
| calcium ion binding | MMP28;ACTN2B;CELSR3;ACTN4;CCDC48;EPDR1;PPP2R3A;CDH12;FAT3A |
| calcium-dependent protein binding | VLDLR;SEC31A;FCN2;VPS37B;A2M;ANXA2;NRXN1;STX1A;SYN1 |
| identical protein binding | PDCD6;SKP2;KHDC1B;ITGA2B;ACADM;FXR2;BCAT1;DNMT3A;TRP53 |
| protein binding | FOXG1;MT3;ZNF124;CD59;EXOSC7;FOXP2;ALOX5;ISYNA1;ROCK1 |
| protein homodimerization activity | RRAGA;Trl;PKD2;DNM1L;JAM3;XBP1;RELA;SLC51A;HIF1AN |
| tau protein binding | S100B;HDAC6;PPP2R2A;DYRK1A;BIN1;FKBP4;SNCA;APOE;AATF |
| zinc ion binding | MYT1;C6AST4;ZDHHC13;ESR1;ZCCHC24;CECR1;ZNF330;PHF23B;ZCCHC12 |
S100B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with S100B here. Most of them are supplied by our site. Hope this information will be useful for your research of S100B.
S100A1
- Q&As
- Reviews
Q&As (5)
Ask a questionElevated S100B levels in the blood can indicate TBI, and its measurement can aid in TBI diagnosis and severity assessment.
S100B can be used to diagnose brain injuries, such as traumatic brain injury and stroke.
S100B levels are typically measured through a blood test.
Results should be interpreted in the context of the patient's clinical history and other diagnostic tests.
S100B may help in monitoring disease progression and severity in conditions like Alzheimer's disease.
Customer Reviews (3)
Write a reviewOne major advantage of S100B protein is its ability to contribute to the understanding of diseases related to aberrant cell cycle regulation, including cancer.
The S100B protein demonstrates exceptional quality, making it an ideal candidate to fulfill my experimental requirements.
The manufacturer of S100B protein plays a crucial role in supporting my research efforts.
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