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CBLC

Official Full Name

Cbl proto-oncogene, E3 ubiquitin protein ligase C
Overview

This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell;signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be;restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been;observed for this gene.
Synonyms

CBLC; Cbl proto-oncogene, E3 ubiquitin protein ligase C; Cas Br M (murine) ecotropic retroviral transforming sequence c , Cas Br M (murine) ectropic retroviral transforming sequence c; signal transduction protein CBL-C; CBL 3; CBL SL; RNF57; RING finger;

Type

Recombinant Proteins
Cell & Tissue Lysates

Species

Human
Mouse
Zebrafish

Source

E.coli
HEK293
HEK293T
In Vitro Cell Free System
Insect Cell
Insect Cells
Mammalian Cell
Wheat Germ

Tag

Fc
FLAG
GST
His
Myc
DDK
Myc|DDK
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	CBLC-442H	Recombinant Human CBLC, His-GST tagged	Insect Cell	Fc		Inquiry
Human	CBLC-10757H	Recombinant Human CBLC, His-tagged	E.coli	His	N-term-350a.a.	$319 / 25ug
Human	CBLC-0461H	Recombinant Human CBLC Protein, GST-Tagged	Wheat Germ	GST		Inquiry
Human	CBLC-001HCL	Recombinant Human CBLC cell lysate	Insect Cell	N/A		Inquiry
Human	CBLC-1512H	Recombinant Human CBLC Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc/DDK		Inquiry
Human	CBLC-443H	Recombinant Human CBLC Protein, FLAG-tagged	HEK293	FLAG		Inquiry
Human	CBLC-2725H	Recombinant Human CBLC Protein, MYC/DDK-tagged	HEK293	Myc/DDK		Inquiry
Human	CBLC-2768HF	Recombinant Full Length Human CBLC Protein, GST-tagged	In Vitro Cell Free System	GST	474 amino acids	Inquiry
Human	CBLC-2206H	Recombinant Human CBLC protein, His&GST-tagged	Insect Cells	His/GST	Met1-Ala474	Inquiry
Mouse	Cblc-1975M	Recombinant Mouse Cblc Protein, Myc/DDK-tagged	HEK293T	Myc/DDK		Inquiry
Zebrafish	CBLC-6818Z	Recombinant Zebrafish CBLC	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein

CBLC involved in several pathways and played different roles in them. We selected most pathways CBLC participated on our site, such as ErbB signaling pathway, Ubiquitin mediated proteolysis, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CBLC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
ErbB signaling pathway	PTK2AA;NRG1;MAPK9;PAK1;MAPK1;MAPK10;RAF1B;RPS6KB2;RAF1A
Ubiquitin mediated proteolysis	UBE2D1;UBE2D1B;HERC4;UBE3A;FBXW11A;PIAS1;UBE2R2;UBE2J1;UBA3
Endocytosis	VTA1;GRK4;HLA-B;ZFP652;CHMP4C;FGFR4;CAV2;SH3GLB2;ARPC5LB
T cell receptor signaling pathway	MAPK3;SHB;PIK3CD;TNF;RAF1;PDPK1;GRB2;GRAPA;CD3E
Insulin signaling pathway	BADB;FOXO1A;AKT2L;SHC2;TSC1;MAP2K2A;PCK1;TRIP10A;SHC3
Bacterial invasion of epithelial cells	ACTG1;CDC42;PTK2;MET;CLTC;RHOA;SEPT1;SEPT11;CRKL
Pathways in cancer	GNAI1;GNG3;ROCK2;PLCB3;PIK3CA;MAP2K2;PTEN;PDGFA;FIGF
Proteoglycans in cancer	HRAS;ANK1;SOS1;TWIST1;Ctsl;FZD10;PTPN11;PXN;WNT1
Chronic myeloid leukemia	TRP53;BCL2L1;IKBKG;AKT2;CCND1;TGFBR1;STAT5B;AKT1;BCR

CBLC has several biochemical functions, for example, SH3 domain binding, calcium ion binding, epidermal growth factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CBLC itself. We selected most functions CBLC had, and list some proteins which have the same functions with CBLC. You can find most of the proteins on our site.

Function	Related Protein
SH3 domain binding	QKI;SH3BP5;SHANK1;PARK2;DOCK4;WAS;NCKIPSD;FUT8;HCLS1
calcium ion binding	BRAF;VSNL1A;MYL4;ANXA1;S100A7A;PVALB7;EDEM2;CDH18A;PCDH1A4
epidermal growth factor receptor binding	ATXN2;SNX2;TNK2;AGR2;SNX1;RNF126;FER;BTC;FAM83B
ligase activity	TRAIP;ITCHA;MYLIPA;TRIM33;XIAP;HERC2;PIAS2;UBE2IB;MARCH5L
phosphotyrosine binding	ZAP70;CBLB;GRB2;STAP1;ACP2;FGR;CBLC;CBL;MAPK3
signal transducer activity	GRM2A;VMN1R48;DRD7;TAAR7F;NPFFR1L1;RGS7;HTR2CL1;TAS2R106;STAT1A
ubiquitin protein ligase activity	C18orf25;ARIH2;ITCH;HECTD3;SIAH2;PRPF19;UBE2N;UBR1;HECW2
zinc ion binding	TRIM31;TRIM72;RNF212;MKRN1;MID1;PDLIM5;ZNF92;EHMT1B;MEP1B

CBLC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CBLC here. Most of them are supplied by our site. Hope this information will be useful for your research of CBLC.

ITCH; CRK; ABI1; HIP2; UBE2L6; NACAD; SHC1; UBE2H; UBE2I; UBE2L3; BIRC2; OXA1L; UBE2R2; TRIM46; recN