Recombinant Human CBLC Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: CBLC-1512H
• Product Overview: CBLC MS Standard C13 and N15-labeled recombinant protein (NP_036248) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 52.5 kDa
• AA Sequence: MALAVAPWGRQWEEARALGRAVRML QRLEEQCVDPRLSVSPPSLRDLLPR TAQLLREVAHSRRAAGGGGPGGPGG SGDFLLIYLANLEAKSRQVAALLPP RGRRSANDELFRAGSRLRRQLAKLA IIFSHMHAELHALFPGGKYCGHMYQ LTKAPAHTFWRESCGARCVLPWAEF ESLLGTCHPVEPGCTALALRTTIDL TCSGHVSIFEFDVFTRLFQPWPTLL KNWQLLAVNHPGYMAFLTYDEVQER LQACRDKPGSYIFRPSCTRLGQWAI GYVSSDGSILQTIPANKPLSQVLLE GQKDGFYLYPDGKTHNPDLTELGQA EPQQRIHVSEEQLQLYWAMDSTFEL CKICAESNKDVKIEPCGHLLCSCCL AAWQHSDSQTCPFCRCEIKGWEAVS IYQFHGQATAEDPGNSSDQEGRELE LGQVPLSAPPLPPRPDLPPRKPRNA QPKVRLLKGNSPPAALGPQDPAPAT RTRPLEQKLISEEDLAANDILDYKD DDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: CBLC Cbl proto-oncogene C [ Homo sapiens (human) ]
• Official Symbol: CBLC
• Synonyms: CBLC; Cbl proto-oncogene, E3 ubiquitin protein ligase C; Cas Br M (murine) ecotropic retroviral transforming sequence c, Cas Br M (murine) ectropic retroviral transforming sequence c; signal transduction protein CBL-C; CBL 3; CBL SL; RNF57; RING finger protein 57; SH3-binding protein CBL-3; SH3-binding protein CBL-C; Cas-Br-M (murine) ectropic retroviral transforming sequence c; Cas-Br-M (murine) ecotropic retroviral transforming sequence c; CBL-3; CBL-SL
• Gene ID: 23624
• mRNA Refseq: NM_012116
• Protein Refseq: NP_036248
• MIM: 608453
• UniProt ID: Q9ULV8