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CDH2

  • Official Full Name

    cadherin 2, type 1, N-cadherin (neuronal)

  • Overview

    This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. [provided by RefSeq, Jul 2008]
  • Synonyms

    CDH2; cadherin 2, type 1, N-cadherin (neuronal); CDHN; NCAD; CD325; CDw325; cadherin-2; N-cadherin 1; neural cadherin; neural-cadherin; cadherin 2, N-cadherin (neuronal); calcium-dependent adhesion protein, neuronal;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Bos taurus (Bovine)
  • Callithrix jacchus (White-tufted-ear marmoset)
  • Chicken
  • Gallus gallus (Chicken)
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)
  • Rat
  • Rhesus monkey
  • Rhinolophus ferrumequinum (Greater horseshoe bat)
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Rabbit
  • Wheat Germ
  • C
  • His
  • Fc
  • Flag
  • GST
  • hIgG1
  • hIgG4
  • His (Fc)
  • Avi
  • His|Flag|StrepII
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CDH2-316H Active Recombinant Human CDH2, Fc tagged Mammalian cells Fc
Human CDH2-315H Recombinant Human CDH2, His-Fc tagged Human Cell Fc
Human CDH2-4938H Recombinant Human CDH2 protein, GST-tagged E.coli GST 421 - 535 aa
Human CDH2-28769TH Recombinant Human CDH2 Wheat Germ N/A 100 amino acids
Human CDH2-2191H Recombinant Human CDH2, His tagged Human Cell His
Human CDH2-7023H Recombinant Human CDH2 protein, His-tagged E.coli His Ser685~Asp784 (Accession # P19022)
Human CDH2-0983H Recombinant Human CDH2 Protein, His-Flag-StrepII-Tagged Human Cell His/Flag/StrepII
Human CDH2-271H Recombinant Human CDH2 Protein, His-tagged Insect Cell His
Human CDH2-0984H Recombinant Human CDH2 Protein, GST-Tagged Wheat Germ GST
Human CDH2-87H Recombinant Human Cadherin 2, Type 1, N-cadherin (Neuronal) E.coli N/A
Human CDH2-980HCL Recombinant Human CDH2 cell lysate Human Cell N/A
Human CDH2-6651H Recombinant Human CDH2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CDH2-3153H Recombinant Human CDH2 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CAB11508RH Rabbit Anti-Human Cadherin 2, type 1, N-cadherin Monoclonal Antibody Rabbit N/A
Human CDH2-001H Recombinant Human CDH2 Protein, His-tagged E.coli His
Human CDH2-877HFL Recombinant Full Length Human CDH2 Protein, C-Flag-tagged Mammalian cells Flag
Human CDH2-44H Recombinant Human CDH2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CDH2-44H-B Recombinant Human CDH2 Protein Pre-coupled Magnetic Beads HEK293
Human CDH2-1306H Recombinant Human CDH2 Protein (Asp160-Ala724), N-His tagged E.coli N-His Asp160-Ala724
Human CDH2-3848H Recombinant Human CDH2 Protein (Met1-Ala724), C-His tagged Mammalian cells C-His Met1-Ala724
Mouse Cdh2-592M Active Recombinant Mouse Cdh2 Protein, Fc Chimera Mammalian cells Fc
Mouse Cdh2-7024M Recombinant Mouse Cdh2 protein, His-tagged E.coli His Leu45~His238 (Accession # P15116)
Mouse CDH2-304M Recombinant Mouse Cdh2, LEVLFQ tagged Human Cell His
Mouse CDH2-971MCL Recombinant Mouse CDH2 cell lysate Human Cell N/A
Mouse Cdh2-21M Recombinant Mouse Cdh2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Cdh2-21M-B Recombinant Mouse Cdh2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Cdh2-861M Recombinant Mouse Cdh2 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat Cdh2-7026R Recombinant Rat Cdh2 protein, His-tagged E.coli His Pro144~Asn273 (Accession # Q9Z1Y3)
Rat CDH2-1290R Recombinant Rat CDH2 Protein Mammalian Cell His
Rat Cdh2-8757R Recombinant Rat Cdh2, His tagged Human Cell His
Rat Cdh2-7025R Recombinant Rat Cdh2 protein, His-tagged E.coli His Ser563~Ser685 (Accession # Q9Z1Y3)
Rat CDH2-948R-B Recombinant Rat CDH2 Protein Pre-coupled Magnetic Beads HEK293
Rat CDH2-948R Recombinant Rat CDH2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus monkey CDH2-1740R Recombinant Rhesus Monkey CDH2 Protein HEK293 N/A
Rhesus monkey CDH2-1741R Recombinant Rhesus Monkey CDH2 Protein, hIgG1-tagged HEK293 hIgG1
Rhesus monkey CDH2-1742R Recombinant Rhesus Monkey CDH2 Protein, hIgG4-tagged HEK293 hIgG4
Bos taurus (Bovine) RFL13992BF Recombinant Full Length Bovine Cadherin-2(Cdh2) Protein, His-Tagged E.coli expression system His Full Length (131-877)
Callithrix jacchus (White-tufted-ear marmoset) RFL6351CF Recombinant Full Length Callithrix Jacchus Cadherin-2(Cdh2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (160-906)
Gallus gallus (Chicken) RFL25845GF Recombinant Full Length Chicken Cadherin-2(Cdh2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (165-912)
Homo sapiens (Human) RFL12778HF Recombinant Full Length Human Cadherin-2(Cdh2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (160-906)
Mus musculus (Mouse) RFL26809MF Recombinant Full Length Mouse Cadherin-2(Cdh2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (160-906)
Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby) RFL30074OF Recombinant Full Length Otolemur Garnettii Cadherin-2(Cdh2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (160-906)
Rhinolophus ferrumequinum (Greater horseshoe bat) RFL35825RF Recombinant Full Length Rhinolophus Ferrumequinum Cadherin-2(Cdh2) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (160-906)
Zebrafish CDH2-8707Z Recombinant Zebrafish CDH2 Mammalian Cell His
Chicken CDH2-1134C Recombinant Chicken CDH2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

CDH2 involved in several pathways and played different roles in them. We selected most pathways CDH2 participated on our site, such as Adherens junctions interactions, Arrhythmogenic right ventricular cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC), which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adherens junctions interactionsCTNNB2;CDH8;JUP;CDH17;CTNND1;CDH24;CDH3;PTBP3;JUPA
Arrhythmogenic right ventricular cardiomyopathyDSC2;DAG1;JUP;CACNG3;CDH2;DSG2;CACNG2;CTNNA1;DMD
Arrhythmogenic right ventricular cardiomyopathy (ARVC)RYR2;CACNG4;PKP2;CACNA2D1;ITGB8;LAMA2;ITGA2;ACTG1;ITGB6
BDNF signaling pathwayGNB2L1;CNR1;CDH2;DOK5;BCL2L11;CFL1;EIF2S1;LINGO1;MAP3K2
CDO in myogenesisMYOD1;SPAG9;MYF6;CTNNA2;CDH2;MEF2AA;MEF2B;MYOG;TCF3B
Cell adhesion molecules (CAMs)CD276;PVRL3B;NCAM1A;ITGA6B;F11R;NFASC;H2-Q10;VCAN;GLG1
Cell junction organizationPLEC;F11R.2;CDH10;CADM2B;CDH12;CDH2;CDH10A;CDH18;CADM2A
Cell-Cell communicationCDH7;CLDN3;CDH5;DSCAM;DSCAMA;ANG;CLDN20;KIRRELA;SIRPB1

CDH2 has several biochemical functions, for example, alpha-catenin binding, beta-catenin binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH2 itself. We selected most functions CDH2 had, and list some proteins which have the same functions with CDH2. You can find most of the proteins on our site.

Function Related Protein
alpha-catenin bindingPKP3;AJUBA;JUB;CTNNB1;CDH2;NUMB;VCL;JUP;CDH24
beta-catenin bindingCTNNA3;C;CDH2;RORA;ASH2L;TRPC4;GRIP1;AXIN1;CD2AP
calcium ion bindingCDH3;JAG1;SLC25A25A;SRI;PCDH2AB6;ITSN1;VIL1;LRP2A;NCALD
gamma-catenin bindingCDH1;Fert2;APC2;FER;PTPRJ;DSG1;CDH2;CTNNA1;TCF7L2
nitric-oxide synthase bindingSLC6A4;CALM3;DNM2;DMD;CAMK2D;CALM1;ACTB;SLC14A2;CALM2
protein bindingMED20;WIPF1;CHMP2B;UFD1L;DHX58;VPS24;PARVB;CACYBP;NINJ2
protein complex bindingKAT2B;MYO7A;KAT6B;SLC25A3;LRP2;RPH3A;TUBB;LEPRE1;VPS28
protein kinase bindingSPDYB;PDGFRB;CAMK2N1;CENPJ;NIPAL1;CDH2;NEK9;CASP9;SKI
protein phosphatase bindingANAPC7;EIF2AK3;IRS2;NEK2;EGFR;PIK3R2;DRD1;KCNN4;MET

CDH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH2.

CTNNB1; PTPRC; PTPRB; PTPRG; PTPN6; PTPN7; PTPN12; PTPRJ; PTPRR; PTPRK; PTPRO; PTPN22; CTNND1; PRKAR1A; JUP; EXOC5

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