CDH2
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Official Full Name
cadherin 2, type 1, N-cadherin (neuronal)
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Overview
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product. [provided by RefSeq, Jul 2008] -
Synonyms
CDH2; cadherin 2, type 1, N-cadherin (neuronal); CDHN; NCAD; CD325; CDw325; cadherin-2; N-cadherin 1; neural cadherin; neural-cadherin; cadherin 2, N-cadherin (neuronal); calcium-dependent adhesion protein, neuronal;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Bos taurus (Bovine)
- Callithrix jacchus (White-tufted-ear marmoset)
- Chicken
- Gallus gallus (Chicken)
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby)
- Rat
- Rhesus monkey
- Rhinolophus ferrumequinum (Greater horseshoe bat)
- Zebrafish
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Human Cell
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Rabbit
- Wheat Germ
- C
- His
- Fc
- Flag
- GST
- hIgG1
- hIgG4
- His (Fc)
- Avi
- His|Flag|StrepII
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | CDH2-316H | Active Recombinant Human CDH2, Fc tagged | Mammalian cells | Fc | ||
Human | CDH2-315H | Recombinant Human CDH2, His-Fc tagged | Human Cell | Fc | ||
Human | CDH2-4938H | Recombinant Human CDH2 protein, GST-tagged | E.coli | GST | 421 - 535 aa | |
Human | CDH2-28769TH | Recombinant Human CDH2 | Wheat Germ | N/A | 100 amino acids | |
Human | CDH2-2191H | Recombinant Human CDH2, His tagged | Human Cell | His | ||
Human | CDH2-7023H | Recombinant Human CDH2 protein, His-tagged | E.coli | His | Ser685~Asp784 (Accession # P19022) | |
Human | CDH2-0983H | Recombinant Human CDH2 Protein, His-Flag-StrepII-Tagged | Human Cell | His/Flag/StrepII | ||
Human | CDH2-271H | Recombinant Human CDH2 Protein, His-tagged | Insect Cell | His | ||
Human | CDH2-0984H | Recombinant Human CDH2 Protein, GST-Tagged | Wheat Germ | GST | ||
Human | CDH2-87H | Recombinant Human Cadherin 2, Type 1, N-cadherin (Neuronal) | E.coli | N/A | ||
Human | CDH2-980HCL | Recombinant Human CDH2 cell lysate | Human Cell | N/A | ||
Human | CDH2-6651H | Recombinant Human CDH2 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK | ||
Human | CDH2-3153H | Recombinant Human CDH2 Protein, MYC/DDK-tagged | HEK293 | Myc/DDK | ||
Human | CAB11508RH | Rabbit Anti-Human Cadherin 2, type 1, N-cadherin Monoclonal Antibody | Rabbit | N/A | ||
Human | CDH2-001H | Recombinant Human CDH2 Protein, His-tagged | E.coli | His | ||
Human | CDH2-877HFL | Recombinant Full Length Human CDH2 Protein, C-Flag-tagged | Mammalian cells | Flag | ||
Human | CDH2-44H | Recombinant Human CDH2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Human | CDH2-44H-B | Recombinant Human CDH2 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Human | CDH2-1306H | Recombinant Human CDH2 Protein (Asp160-Ala724), N-His tagged | E.coli | N-His | Asp160-Ala724 | |
Human | CDH2-3848H | Recombinant Human CDH2 Protein (Met1-Ala724), C-His tagged | Mammalian cells | C-His | Met1-Ala724 | |
Mouse | Cdh2-592M | Active Recombinant Mouse Cdh2 Protein, Fc Chimera | Mammalian cells | Fc | ||
Mouse | Cdh2-7024M | Recombinant Mouse Cdh2 protein, His-tagged | E.coli | His | Leu45~His238 (Accession # P15116) | |
Mouse | CDH2-304M | Recombinant Mouse Cdh2, LEVLFQ tagged | Human Cell | His | ||
Mouse | CDH2-971MCL | Recombinant Mouse CDH2 cell lysate | Human Cell | N/A | ||
Mouse | Cdh2-21M | Recombinant Mouse Cdh2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | Cdh2-21M-B | Recombinant Mouse Cdh2 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | Cdh2-861M | Recombinant Mouse Cdh2 Protein, MYC/DDK-tagged | HEK293T | MYC/DDK | ||
Rat | Cdh2-7026R | Recombinant Rat Cdh2 protein, His-tagged | E.coli | His | Pro144~Asn273 (Accession # Q9Z1Y3) | |
Rat | CDH2-1290R | Recombinant Rat CDH2 Protein | Mammalian Cell | His | ||
Rat | Cdh2-8757R | Recombinant Rat Cdh2, His tagged | Human Cell | His | ||
Rat | Cdh2-7025R | Recombinant Rat Cdh2 protein, His-tagged | E.coli | His | Ser563~Ser685 (Accession # Q9Z1Y3) | |
Rat | CDH2-948R-B | Recombinant Rat CDH2 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Rat | CDH2-948R | Recombinant Rat CDH2 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rhesus monkey | CDH2-1740R | Recombinant Rhesus Monkey CDH2 Protein | HEK293 | N/A | ||
Rhesus monkey | CDH2-1741R | Recombinant Rhesus Monkey CDH2 Protein, hIgG1-tagged | HEK293 | hIgG1 | ||
Rhesus monkey | CDH2-1742R | Recombinant Rhesus Monkey CDH2 Protein, hIgG4-tagged | HEK293 | hIgG4 | ||
Bos taurus (Bovine) | RFL13992BF | Recombinant Full Length Bovine Cadherin-2(Cdh2) Protein, His-Tagged | E.coli expression system | His | Full Length (131-877) | |
Callithrix jacchus (White-tufted-ear marmoset) | RFL6351CF | Recombinant Full Length Callithrix Jacchus Cadherin-2(Cdh2) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (160-906) | |
Gallus gallus (Chicken) | RFL25845GF | Recombinant Full Length Chicken Cadherin-2(Cdh2) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (165-912) | |
Homo sapiens (Human) | RFL12778HF | Recombinant Full Length Human Cadherin-2(Cdh2) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (160-906) | |
Mus musculus (Mouse) | RFL26809MF | Recombinant Full Length Mouse Cadherin-2(Cdh2) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (160-906) | |
Otolemur garnettii (Small-eared galago) (Garnett's greater bushbaby) | RFL30074OF | Recombinant Full Length Otolemur Garnettii Cadherin-2(Cdh2) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (160-906) | |
Rhinolophus ferrumequinum (Greater horseshoe bat) | RFL35825RF | Recombinant Full Length Rhinolophus Ferrumequinum Cadherin-2(Cdh2) Protein, His-Tagged | E.coli expression system | His | Full Length of Mature Protein (160-906) | |
Zebrafish | CDH2-8707Z | Recombinant Zebrafish CDH2 | Mammalian Cell | His | ||
Chicken | CDH2-1134C | Recombinant Chicken CDH2 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
CDH2 involved in several pathways and played different roles in them. We selected most pathways CDH2 participated on our site, such as Adherens junctions interactions, Arrhythmogenic right ventricular cardiomyopathy, Arrhythmogenic right ventricular cardiomyopathy (ARVC), which may be useful for your reference. Also, other proteins which involved in the same pathway with CDH2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Adherens junctions interactions | CTNNB2;CDH8;JUP;CDH17;CTNND1;CDH24;CDH3;PTBP3;JUPA |
Arrhythmogenic right ventricular cardiomyopathy | DSC2;DAG1;JUP;CACNG3;CDH2;DSG2;CACNG2;CTNNA1;DMD |
Arrhythmogenic right ventricular cardiomyopathy (ARVC) | RYR2;CACNG4;PKP2;CACNA2D1;ITGB8;LAMA2;ITGA2;ACTG1;ITGB6 |
BDNF signaling pathway | GNB2L1;CNR1;CDH2;DOK5;BCL2L11;CFL1;EIF2S1;LINGO1;MAP3K2 |
CDO in myogenesis | MYOD1;SPAG9;MYF6;CTNNA2;CDH2;MEF2AA;MEF2B;MYOG;TCF3B |
Cell adhesion molecules (CAMs) | CD276;PVRL3B;NCAM1A;ITGA6B;F11R;NFASC;H2-Q10;VCAN;GLG1 |
Cell junction organization | PLEC;F11R.2;CDH10;CADM2B;CDH12;CDH2;CDH10A;CDH18;CADM2A |
Cell-Cell communication | CDH7;CLDN3;CDH5;DSCAM;DSCAMA;ANG;CLDN20;KIRRELA;SIRPB1 |
CDH2 has several biochemical functions, for example, alpha-catenin binding, beta-catenin binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CDH2 itself. We selected most functions CDH2 had, and list some proteins which have the same functions with CDH2. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
alpha-catenin binding | PKP3;AJUBA;JUB;CTNNB1;CDH2;NUMB;VCL;JUP;CDH24 |
beta-catenin binding | CTNNA3;C;CDH2;RORA;ASH2L;TRPC4;GRIP1;AXIN1;CD2AP |
calcium ion binding | CDH3;JAG1;SLC25A25A;SRI;PCDH2AB6;ITSN1;VIL1;LRP2A;NCALD |
gamma-catenin binding | CDH1;Fert2;APC2;FER;PTPRJ;DSG1;CDH2;CTNNA1;TCF7L2 |
nitric-oxide synthase binding | SLC6A4;CALM3;DNM2;DMD;CAMK2D;CALM1;ACTB;SLC14A2;CALM2 |
protein binding | MED20;WIPF1;CHMP2B;UFD1L;DHX58;VPS24;PARVB;CACYBP;NINJ2 |
protein complex binding | KAT2B;MYO7A;KAT6B;SLC25A3;LRP2;RPH3A;TUBB;LEPRE1;VPS28 |
protein kinase binding | SPDYB;PDGFRB;CAMK2N1;CENPJ;NIPAL1;CDH2;NEK9;CASP9;SKI |
protein phosphatase binding | ANAPC7;EIF2AK3;IRS2;NEK2;EGFR;PIK3R2;DRD1;KCNN4;MET |
CDH2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CDH2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CDH2.
CTNNB1; PTPRC; PTPRB; PTPRG; PTPN6; PTPN7; PTPN12; PTPRJ; PTPRR; PTPRK; PTPRO; PTPN22; CTNND1; PRKAR1A; JUP; EXOC5
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