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MAPK13

  • Official Full Name

    mitogen-activated protein kinase 13

  • Overview

    The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and cellular stress. MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase.
  • Synonyms

    MAPK13; mitogen-activated protein kinase 13; PRKM13; p38delta; SAPK4; MAPK 13; MAP kinase 13; MAP kinase p38 delta; stress-activated protein kinase 4; mitogen-activated protein kinase p38 delta; MGC99536;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Human
  • Mouse
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Insect Cell
  • Insect Cells
  • Sf9 Insect Cell
  • GST
  • His
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAPK13-357H Active Recombinant Human MAPK13 protein, GST-tagged Insect Cells GST Met1-Leu365
Human MAPK13-374H Recombinant Human MAPK13, GST-tagged, Active Sf9 Insect Cell GST
Human MAPK13-48H Recombinant Human MAPK13, GST-tagged Sf9 Insect Cell GST
Human MAPK13-31379TH Recombinant Human MAPK13, His-tagged E.coli His 365 amino acids
Human MAPK13-737H Recombinant Human Mitogen-activated Protein Kinase 13 E.coli N/A
Human MAPK13-945H Recombinant Human MAPK13 protein, GST-tagged Insect Cells GST Met1-Leu365
Human MAPK13-1285H Recombinant Human Mitogen-Activated Protein Kinase 13, His-tagged Human His
Human MAPK13-31H Recombinant human biotinylated MAPK13, His-tagged E.coli His
Human MAPK13-31380TH Recombinant Human MAPK13 N/A
Human MAPK13-574HCL Recombinant Human MAPK13 cell lysate Insect Cell N/A
Human MAPK13-4999H Recombinant Human MAPK13 Protein (Tyr25-Phe308), N-His tagged E.coli N-His Tyr25-Phe308
Human MAPK13-383H Recombinant Human MAPK13 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MAPK13-2436H Recombinant Human MAPK13 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MAPK13-1089H Recombinant Human MAPK13 Protein (S2-L365), GST tagged Insect Cell GST S2-L365
Human MAPK13-3205H Recombinant Human MAPK13 protein, His-SUMO-tagged E.coli His-SUMO 1-365aa
Human MAPK13-1297HF Active Recombinant Full Length Human MAPK13 Protein, GST-tagged E.coli GST 1-365
Human MAPK13-1088H Recombinant Human MAPK13 Protein (S2-L365), Tag Free Insect Cell No tag S2-L365
Mouse Mapk13-3940M Recombinant Mouse Mapk13 Protein, Myc/DDK-tagged HEK293T Myc/DDK
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MAPK13 Related Research Area
  • MAPK13 Related Signal Pathway

MAPK13 involved in several pathways and played different roles in them. We selected most pathways MAPK13 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, FoxO signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAPK13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayRPS6KA6;CACNG7;MKNK2A;PPP3CA;MAPKAPK5;STK4;PPM1AB;FLNC;ATF4B1
Rap signaling pathwayPLCB1;PIK3R2;FGF18;RASGRP3;PRKCI;FGF19;GRIN1;PRKCA;FGFR3
FoxO signaling pathwayGRB2A;AKT2L;PCK1;PRMT1;GABARAPL2;FOXO1;SGK2;PDPK1;PRKAB2
Sphingolipid signaling pathwayTP53;PRKCZ;PLCB4;AKT2;PIK3R3;PPP2R2D;SPTLC2;CERS4;PIK3CB
Adrenergic signaling in cardiomyocytesATP2B3B;CACNG3;ADCY2B;CACNG1A;SLC9A1;PLCB2;PPP2R2D;PPP1CAB;PPP2R5EA
VEGF signaling pathwayRAF1;MAP2K1;KRAS;PIK3R1;PLCG1;PTGS2;PTK2;PIK3R3B;NRAS
Osteoclast differentiationACP5;IFNGR2;LILRB2;TREM2;CAMK4;SFPI1;IL1A;BLNK;TNF
Signaling pathways regulating pluripotency of stem cellsFzd4;SETDB1;WNT4;MAPK11;LIFR;NEUROG1;INHBA;SMAD4;FZD8
Platelet activationTBXA2R;F2R;ITGA2B;VAMP8;P2RY12;STIM1;P2RY1;RHOA;BTK
Toll-like receptor signaling pathwayNFKBIAA;TRAF3;IFNPHI3;TBK1;TAB2;TLR7;CCL3L1;IFNB1;TLR3
NOD-like receptor signaling pathwayMAPK14A;MAPK10;HSP90B1;IL8L2;TRAF6;BIRC3;NAIP6;CXCL1;NFKBIAA
RIG-I-like receptor signaling pathwayTNF;IFNA17;CXCL8B.3;NFKBIAB;RNF125;AZI2;MAPK14B;MAPK10;MAPK8B
T cell receptor signaling pathwayAKT2;PIK3CG;IL4;MAPK1;CARD11;MAPK13;CD3E;CD4;MAPK11
Fc epsilon RI signaling pathwayAKT2;PIK3R2;MAPK9;PRKCA;VAV3;LYN;MAP2K6;PLA2G4F;AKT1
TNF signaling pathwayMAPK10;IL18R1;IKBKB;CASP8;PIK3CD;MMP9;MMP14;TAB2;CREB3L3
Leukocyte transendothelial migrationMYL2;ITGB2L;ARHGAP5;CLDN20;CLDN14;VASP;CTNNA3;VCL;AASS
Neurotrophin signaling pathwayNTF4;BAD;NFKBIA;MAPK8;ATF4;PLCG1;PIK3CD;CALML5;AKT2
Retrograde endocannabinoid signalingITPR3;GNB1;Adcy4;MAPK9;SLC17A8;MAPK1;GABRG2;PLCB4;GNAO1
Dopaminergic synapsePPP2CA;CAMK2G;CREB5;FOS;PRKACA;GNG4;COMT;AKT1;GRIA4
Inflammatory mediator regulation of TRP channelsNTRK1;PIK3R1;PIK3CB;IL1RAP;PRKACB;PRKCQ;Adcy4;GNAS;GNAQ
GnRH signaling pathwayMMP14;KRAS;MAP2K1;CAMK2B;MAPK12;MAP2K2;PRKCDA;CALM1;PTK2B
Progesterone-mediated oocyte maturationMAD2L1;MAPK11;RPS6KA1;GNAI1;AKT2L;INS2;PIK3R2;MAPK12;ANAPC5
Prolactin signaling pathwayTH;ELF5;PIK3R3;PRP2;SOS1;CSN2;SHC1;SOCS4;GRB2
Amyotrophic lateral sclerosis (ALS)TNF;DERL1;GRIN1;CASP9;GRIA1;ALS2;GRIN2B;MAP3K5;MAPK13
Epithelial cell signaling in Helicobacter pylori infectionMAP3K14;ATP6V0C;TJP1;GIT1;ATP6AP1;MET;F11R;CCL5;NFKB1
ShigellosisFBXW11;DIAPH1;ARPC5L;CDC42;ITGB1;NFKB1;CD44;MAPK10;RIPK2
Salmonella infectionIL1B;CD14;RAB7A;ARPC4L;RAB7;TJP1;TLR4BA;RHOGB;CXCL8B.3
PertussisGM5077;NFKB1;C4A;PYCARD;ITGAM;CALML3;IL6;GNAI2;GNAI3
LeishmaniasisMAPK13;NFKB1;IRAK1;ITGB2L;STAT1;PTPN6;FCGR3;MAPK1;ITGB2
Chagas disease (American trypanosomiasis)MAPK8;NFKB1;SMAD2;IL10;PPP2R2A;C1QB;PLCB2;AKT2;IFNG
ToxoplasmosisHLA-DQA1;MAPK1;ITGA6;PIK3R1;BCL2;XIAP;PPIF;LAMA5;TNF
TuberculosisNFYB;NOS2;BID;ATP6V0C;NFKB1;HLA-DRB5;CALM2;RAB5B;BAD
Hepatitis CIFNA21;IFNA10;OAS1A;LDLR;IFNAR1;SOS1;IFNA16;PIK3CG;IFNA14
Influenza AIFNA5;MAPK8;IL6;Ccl12;NFKBIB;RAF1;MAP2K7;NXT1;IFN-a
Epstein-Barr virus infectionHSPA2;EIF2AK2;SND1;EP300;POLR3K;HLA-DPB1;TRAF2;AKT2;POLR2J2
Proteoglycans in cancerHSPB2;WNT6;CAMK2B;ACTB;MMP2;KRAS;PLCE1;CBLC;MAP2K2

MAPK13 has several biochemical functions, for example, ATP binding, MAP kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAPK13 itself. We selected most functions MAPK13 had, and list some proteins which have the same functions with MAPK13. You can find most of the proteins on our site.

Function Related Protein
ATP bindingDSTYK;MINK1;ACTC1B;ATP2B1;SHPRH;NPR1A;HELZ2;PDGFRA;CKMT1B
MAP kinase activityNLK1;MAPK12B;MAPK8B;MAPK8A;MAPK12;NLK2;MAPK4;NLK;MAPK3
protein bindingWHRN;CHRNA5;CDKN1C;RAB27B;ITGB3B;NAT2;RAG1;HBP1;FBXO17
protein serine/threonine kinase activityROCK2A;IRAK1;TBK1;MTOR;SRPK3;PRKCZ;MAP4K5;MAPK1;EIF2AK4

MAPK13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAPK13 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAPK13.

PRKD1; FPR1; saicar; PKM; ATF2; MAPKAPK3; Pkd1; MAP3K4; GPX4; SMAD4; ANKLE2; AKIP1; pi3p

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