il2
Share
  • Official Full Name
  • interleukin 2
  • Background
  • IL-2 is amember of a family of cytokines, which also includes IL-4, IL-7, IL-9, IL-15and IL-21. IL-2 signals through a receptor complex consisting of IL-2specific IL-2 receptor alpha (CD25), IL-2 receptor beta (CD122) and a commongamma chain (γc), which is shared by all members of this family of cytokines.Binding of IL-2 activates the Ras/MAPK, JAK/Stat and PI 3-kinase/Aktsignaling modules.
    IL-2 isnormally produced by the body during an immune response. When environmentalsubstances (molecules or microbes) gain access to the body, these substancesare recognized as foreign by antigen receptors that are expressed on thesurface of lymphocytes. Antigen binding to the T cell receptor (TCR)stimulates the secretion of IL-2, and the expression of IL-2 receptors IL-2R.The IL-2/IL-2R interaction then stimulates the growth, differentiation andsurvival of antigen-selected cytotoxic T cells via the activation of theexpression of specific genes. As such, IL-2 is necessary for the developmentof T cell immunologic memory, one of the unique characteristics of the immunesystem, which depends upon the expansion of the number and function ofantigen-selected T cell clones.
    IL-2 isalso necessary during T cell development in the thymus for the maturation ofa unique subset of T cells that are termed regulatory T cells (Tregs). Afterexiting from the thymus, T-Regs function to prevent other T cells fromrecognizing and reacting against "self antigens", which couldresult in "autoimmunity". T-Regs do so by preventing the respondingcells from producing IL-2. Thus, IL-2 is required to discriminate betweenself and nonself, another one of the unique characteristics of the immunesystem.
    IL-2 hasbeen found to be similar to IL-15 in terms of function. Both cytokines areable to facilitate production of immunoglobulins made by B cells and inducethe differentiation and proliferation of natural killer cells. The primarydifferences between IL-2 and IL-15 are found in adaptive immune responses.For example, IL-2 participates in maintenance of T-Regs and reducesselfreactive T cells. On the other hand, IL-15 is necessary for maintaininghighly specific T cell responses by supporting survival of CD8 memory Tcells.
  • Synonyms
  • IL-2; interleukin 2; TCGF; lymphokine; interleukin-2; aldesleukin; T cell growth factor; involved in regulation of T-cell clonal expansion; Il2; OTTMUSP00000007837; T-cell growth factor
Cat.#:IL2-464HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 2
+Inquiry
Cat.#:IL2-513HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 2
+Inquiry
Cat.#:Il2-465MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin 2
+Inquiry
Cat.#:IL2-134HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL2 protein
+Inquiry
Cat.#:IL2-167HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL2, MIgG2a Fc-tagged
+Inquiry
Cat.#:IL2-169HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL2, HIgG1 Fc-tagged, mutant
+Inquiry
Cat.#:IL2-170HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL2, HIgG1 Fc-tagged
+Inquiry
Cat.#:IL2-219HTag:StrepII
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL2, StrepII-tagged
+Inquiry
Cat.#:IL2-25HTag:His
Source (Host):Barley grain (Hordeum vulgare)Species:Human
Product nameRecombinant Human IL2, His-tagged
+Inquiry
Cat.#:IL2-2741HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IL2
+Inquiry
Cat.#:IL2-28256THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL2
+Inquiry
Cat.#:IL2-28278THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL2
+Inquiry
Cat.#:IL2-29770THTag:His
Source (Host):Species:Human
Product nameRecombinant Human IL2, His-tagged
+Inquiry
Cat.#:IL2-29771THTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL2 protein
+Inquiry
Cat.#:IL2-29772THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL2, His-tagged
+Inquiry
Cat.#:IL2-29HTag:
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human IL2 protein
+Inquiry
Cat.#:IL2-305HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human IL2, Fc-tagged
+Inquiry
Cat.#:IL2-306HTag:Fc
Source (Host):NS0Species:Human
Product nameRecombinant Human IL2, Fc-tagged
+Inquiry
Cat.#:IL2-310HTag:Fc
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IL2
+Inquiry
Cat.#:IL2-473HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human IL2 protein, His-tagged
+Inquiry
Cat.#:IL2-501HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL2, His tagged
+Inquiry
Cat.#:IL2-502HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL2
+Inquiry
Cat.#:IL2-503HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IL2
+Inquiry
Cat.#:IL2-68HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human IL-2
+Inquiry
Cat.#:IL2-8861HTag:
Source (Host):Hordeum vulgareSpecies:Human
Product nameRecombinant Human Interleukin 2, His-tagged
+Inquiry
Cat.#:IL2-168HTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Human il2, MIgG2a Fc-tagged, mutant
+Inquiry
Cat.#:Il2-307MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Il2, Fc-tagged
+Inquiry
Cat.#:Il2-308MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Il2, Fc-tagged
+Inquiry
Cat.#:IL2-333MTag:Fc
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse IL2, MIgG2a Fc-tagged
+Inquiry
Cat.#:Il2-516MTag:His
Source (Host):HEK293FSpecies:Mouse
Product nameRecombinant Mouse Il2 protein, His-tagged
+Inquiry
Cat.#:Il2-553MTag:His
Source (Host):HEK293FSpecies:Mouse
Product nameRecombinant Mouse Il2 protein, His-tagged
+Inquiry
Cat.#:Il2-637MTag:His & T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il2 protein, His & T7-tagged
+Inquiry
Cat.#:Il2-687MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il2
+Inquiry
Cat.#:IL2-955MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse IL2 Protein
+Inquiry
Cat.#:IL2-3038RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat IL2 Protein
+Inquiry
Cat.#:Il2-479RTag:His
Source (Host):HEK293FSpecies:Rat
Product nameRecombinant Rat Il2 protein, His-tagged
+Inquiry
Cat.#:Il2-575RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il2
+Inquiry
Cat.#:IL2-611RTag:Fc
Source (Host):CHOSpecies:Rat
Product nameRecombinant Rat Interleukin 2, HIgG1 Fc-tagged
+Inquiry
Cat.#:Il2-638RTag:His & GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il2 protein, His & GST-tagged
+Inquiry
Cat.#:Il2-747RTag:None
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il2, None tagged
+Inquiry
Cat.#:IL2-616CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL2 Protein, His-tagged
+Inquiry
Cat.#:IL2-2242RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IL2 Protein, His-tagged
+Inquiry
Cat.#:IL2-5729CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IL2
+Inquiry
Cat.#:IL2-636CTag:His & S
Source (Host):E. coliSpecies:Chicken
Product nameRecombinant Chicken IL2 protein, His & S-tagged
+Inquiry
Cat.#:IL2-699RTag:Met
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit IL2, Met-tagged
+Inquiry
Cat.#:IL2-260FTag:N/A
Source (Host):YeastSpecies:Feline
Product nameRecombinant Feline IL2 protein
+Inquiry
Cat.#:Il2-381CTag:Met
Source (Host):E. coliSpecies:Cotton Rat
Product nameRecombinant Cotton Rat Il2, Met-tagged
+Inquiry
Cat.#:IL2-600PTag:
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig IL2
+Inquiry
Cat.#:IL2-635CTag:His & T7
Source (Host):E. coliSpecies:Cattle
Product nameRecombinant Cattle IL2 protein, His & T7-tagged
+Inquiry
Cat.#:IL2-672ETag:Met
Source (Host):E. coliSpecies:Equine
Product nameRecombinant Equine IL2, Met-tagged
+Inquiry
Cat.#:IL2-83PTag:
Source (Host):E. coliSpecies:Porcine
Product nameRecombinant Porcine IL2 Protein
+Inquiry
Cat.#:IL2-028ETag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL2 (21-153aa), Met tagged
+Inquiry
Cat.#:IL2-341HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL2
+Inquiry
Cat.#:IL2-376HTag:HIS
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin-2, His-tagged
+Inquiry
Cat.#:IL2-402HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin-2 His Tag
+Inquiry
Cat.#:IL2-553HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin 2
+Inquiry
Cat.#:IL2-636HTag:HQ
Source (Host):Hordeum vulgare (barley grain)Species:Human
Product nameRecombinant Human Interleukin 2, HQ-tagged
+Inquiry
Cat.#:IL2-638HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Interleukin 2
+Inquiry
Cat.#:IL2-741HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human interleukin 2
+Inquiry
Cat.#:IL2-403MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin-2, His Tag
+Inquiry
Cat.#:Il2-649MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin 2
+Inquiry
Cat.#:ll2-538MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin 2, His-tagged
+Inquiry
Cat.#:IL2-590CTag:N/A
Source (Host):COSSpecies:Chicken
Product nameRecombinant Chicken IL2
+Inquiry
Cat.#:IL2-06HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Interleukin-2
+Inquiry
Cat.#:IL2-116HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Interleukin 2
+Inquiry
Cat.#:Il2-106MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin-2, His-tagged
+Inquiry
Cat.#:Il2-73MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Interleukin 2
+Inquiry
Cat.#:Il2-168RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Interleukin 2
+Inquiry
Cat.#:Il2-94PTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Interleukin 2
+Inquiry
Cat.#:IL2-249CTag:N/A
Source (Host):YeastSpecies:Chicken
Product nameRecombinant Chicken Interleukin 2
+Inquiry
Cat.#:IL2-255ETag:N/A
Source (Host):YeastSpecies:Equine
Product nameRecombinant Equine Interleukin 2
+Inquiry
Cat.#:IL2-5234HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human IL2 293 Cell Lysate
+Inquiry
Cat.#:IL2-122HGTag:
Source (Host):E. coliSpecies:Human
Product nameGMP Recombinant Human IL2 Protein
+Inquiry
Cat.#:IL2-152HGTag:His
Source (Host):HEK293 cellSpecies:Human
Product nameGMP Recombinant Human IL2 Protein
+Inquiry
Cat.#:IL2-4317HGTag:
Source (Host):E. coliSpecies:Human
Product nameGMP Recombinant Human IL2 protein
+Inquiry
Cat.#:IL2-80HTag:
Source (Host):Species:Human
Product nameHuman Interleukin- 2 (rDNA derived) Reference standard
+Inquiry
Cat.#:Il2-131MTag:
Source (Host):Species:Mouse
Product nameMouse Interleukin-2 (rDNA derived) Reference standard
+Inquiry
Cat.#:diphtheria toxin&IL2-P031HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL2/diphtheria toxin, His-tagged therapeutic protein
+Inquiry
Cat.#:IL2-P044HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL2 therapeutic protein
+Inquiry
Cat.#:CSC-TP006Tag:
Source (Host):CHOSpecies:Human
Product nameHuman IL2 Stable Cell Line-CHO
+Inquiry
Cat.#:CSC-TP036Tag:His
Source (Host):CHOSpecies:Human
Product nameHuman IL-2/Diphtheriae diphtheria toxin fragments A and B, His-tagged Stable Cell Line-CHO
+Inquiry
Cat.#:CSC-TP058Tag:
Source (Host):E. coliSpecies:Human
Product nameHuman IL2 Stable Cell Line-E. coli
+Inquiry
Cat.#:CSC-TP073Tag:
Source (Host):E. coliSpecies:Human
Product nameHuman IL2 Stable Cell Line-E. coli
+Inquiry
Cat.#:CSC-P0836Tag:
Source (Host):Species:Human
Product nameAnti-Human IL2 MAb Stable Cell Line-CHO
+Inquiry
Cat.#:CSC-P0837Tag:
Source (Host):Species:Human
Product nameAnti-Human IL2 F(ab) Stable Cell Line-CHO
+Inquiry
Cat.#:CSC-P0838Tag:
Source (Host):Species:Human
Product nameAnti-Human IL2 scFv Stable Cell Line-CHO
+Inquiry

IL2 Related Articles

Monzani, PS; Guemra, S; et al. MAC-T Cells as a Tool to Evaluate Lentiviral Vector Construction Targeting Recombinant Protein Expression in Milk. ANIMAL BIOTECHNOLOGY 26:136-142(2015).
Habibi, D; Shamsian, A; et al. Synthesis of pyranopyrazoles, benzopyrans, amino-2-chromenes and dihydropyrano[c]chromenes using ionic liquid with dual Bronsted acidic and Lewis basic sites. CHEMICAL PAPERS 69:586-595(2015).

IL2 Related Gene Family

IL