Common gamma Chain Receptor Family Ligands
About Common gamma Chain Receptor Family Ligands
Common gamma chain (γc) is a transmembrane protein encoded by the CD132 gene. It is a common signal transducer for many cytokine receptors, including IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21, etc. γc has two isoforms: long-chain γc and short-chain γc. Long-chain γc is found in T cells, B cells, and natural killer (NK) cells, while short-chain γc is found mainly in monocytes and dendritic cells. Both isoforms are structurally similar, consisting of a single transmembrane protein with an extracellular domain that binds to ligands and an intracellular region involved in signaling.
Fig.1 Schematic of γ chain (γc) family cytokines and their receptors. Shown are how Janus kinase (JAK)1 and JAK3 associate with each receptor, the signal transducers and activators of transcription (STAT) proteins activated by each cytokine, and the major actions of these cytokines on the development and function immune cells. The STAT proteins predominantly activated by each cytokine are in bold. IL, Interleukin; Th, T helper; Tfh, T follicular helper; Treg, regulatory T; NK, natural killer; Ig, immunoglobulin; DCs, dendritic cells; AICD, activation-induced cell death. (Lin J X, et al., 2018)
γc plays a key role in cytokine signaling. Together with cytokine-specific receptors, it forms the corresponding cytokine receptor complex, which activates the signaling pathway. The signaling pathways activated by this family include the PI3-K-Akt pathway, the Ras-MAPK pathway, and the Jak- STAT pathway. γc deletion leads to X-linked severe combined immunodeficiency (X-SCID), a disease in which the immune system is severely impaired and susceptible to infection and death. The discovery of common γ chain receptors provides a new therapeutic approach to treat X-SCID by using cytokines with long-chain γc. For example, cytokines such as IL-2, IL-4, and IL-7, together with γc, can promote the proliferation and differentiation of T, B, and NK cells, thus restoring immune function. In addition, for other immune diseases and tumors, γc can also be used to develop new therapeutic approaches.
Available Resources of Common gamma Chain Receptor Family Ligands
Common γ Chain Receptor Family Ligand Products
Creative BioMart offers a wide range of common gamma chain receptor family ligands which include IL-2, IL-4, IL-7, IL-9, IL15, and IL21, also includes recombinant proteins, GMP proteins, cell & tissue lysates, transfected stable cell lines, protein pre-coupled magnetic beads, therapeutic proteins, antibody, and other related products.
Experiment Consulting and Design Service
Our team of scientists has the experience and expertise to provide you with experiment consulting and design services on common gamma chain receptor family ligands. Whether it is about experimental design, data interpretation, or other related issues, we are willing to cooperate with you and provide assistance.
Technical Support and Educational Resources
We provide technical support and educational resources to help researchers understand the basics of gamma chain receptor family ligands, experimental techniques, and areas of application, and to assist in the proper use and interpretation of related products, as described on specific web pages.
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Reference:
- Lin J X, Leonard W J. The Common Cytokine Receptor γ Chain Family of Cytokines[J]. Cold Spring Harbor Lab, 2018(9).
