RBP4
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Official Full Name
retinol binding protein 4, plasma
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Overview
This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. -
Synonyms
RBP4; retinol binding protein 4, plasma; RDCCAS; retinol-binding protein 4; RBP; PRBP; plasma retinol-binding protein; retinol-binding protein 4, interstitial; Retinol-binding protein 4; Plasma retinol-binding protein;
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- C
- 6×His
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- His
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- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
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- Involved Pathway
- Protein Function
- Interacting Protein
- RBP4 Related Articles
- RBP4 Related Research Area
RBP4 involved in several pathways and played different roles in them. We selected most pathways RBP4 participated on our site, such as Disease, Diseases associated with visual transduction, Diseases of signal transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with RBP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Disease | OPN1LW;EEF2;GCKR;NUP35;CTBP1;HEY1;JAG1;CUX1;LTF |
Diseases associated with visual transduction | RLBP1;OPN1MW2;STRA6;OPN1MW;TTR;OPN1LW;OPN1SW;RBP1;RBP4 |
Diseases of signal transduction | FKBP1A;CCNC;TNKS;MYO18A;MIB1;CDC37;CUX1;RBP4;LRRFIP1 |
Retinoid cycle disease events | RBP1;STRA6;RLBP1;RBP4 |
Retinoid metabolism and transport | APOC2;CLPS;APOA4B.1;AKR1C21;AKR1C6;BCO2L;APOA4A;RBP2A;RBP1 |
SREBP signalling | INSIG1;RNF139;SEC23B;RBP4;DBI;INSIG2 |
Signal Transduction | GMIP;PRICKLE1B;KTN1;TLE3;USP15;ADM;GPR65;KDM4C;LINGO1 |
The canonical retinoid cycle in rods (twilight vision) | STRA6;DHRS9;RPE65A;RDH10;RPE65B;RLBP1A;RLBP1B;RDH12;SDR9C7 |
RBP4 has several biochemical functions, for example, protein binding, protein heterodimerization activity, retinal binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RBP4 itself. We selected most functions RBP4 had, and list some proteins which have the same functions with RBP4. You can find most of the proteins on our site.
Function | Related Protein |
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protein binding | SOX15;COL10A1;COA3;LARP1;SMARCD3;RNF7;SUN2;TFDP2;SGCA |
protein heterodimerization activity | GTF2A2;TLR6;EXT2;JDP2;HIST1H2BK;BHLHE40;LIFR;H2AFVA;BOKB |
retinal binding | RBP1;RBP5;RBP3;RBP2B;RBP4;RBP7;RBP2;RBP2A;CRABP1 |
retinol binding | RBP2;CRABP2;ADH4;RBP5;RLBP1;CRABP1;RBP3;RBP4;ADH7 |
retinol transporter activity |
RBP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RBP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of RBP4.
TTR; TTR; GRB2; q9wmx2-pro_0000037550
- Q&As
- Reviews
Q&As (5)
Ask a questionStudies have indicated a link between elevated RBP4 levels and a decreased risk of certain cancers, although more research is needed in this area.
Some studies suggest a potential association between RBP4 levels and neurodegenerative disorders like Alzheimer's disease.
RBP4 has been investigated in gestational diabetes, showing potential as a marker for metabolic complications during pregnancy.
While RBP4 shows promise as a biomarker, its clinical utility is still under investigation and requires further validation.
Yes, research has shown that RBP4 levels can differ between genders, potentially affecting metabolic health differently.
Customer Reviews (3)
Write a reviewThe manufacturer's dedicated and knowledgeable support team is readily available to address any concerns, provide guidance, and offer timely solutions.
In addition to its impeccable quality, the manufacturer of the RBP4 protein provides outstanding technical support that can efficiently resolve any challenges encountered during my experiments.
Such attentive support significantly minimizes potential setbacks and facilitates a seamless and efficient experimental process.
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