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RBP4

  • Official Full Name

    retinol binding protein 4, plasma

  • Overview

    This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells.
  • Synonyms

    RBP4; retinol binding protein 4, plasma; RDCCAS; retinol-binding protein 4; RBP; PRBP; plasma retinol-binding protein; retinol-binding protein 4, interstitial; Retinol-binding protein 4; Plasma retinol-binding protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Others
  • Canine
  • Cattle
  • Chicken
  • Cynomolgus
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293 cells
  • HEK293F
  • HEK293T
  • Human Cell
  • Human Plasma
  • Mammalian Cell
  • Mammalian cells
  • NS0
  • Yeast
  • C
  • 6×His
  • 8His
  • hFc
  • His
  • Flag
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RBP4-111H Recombinant Human Retinol Binding Protein 4, Plasma E.coli N/A
Human RBP4-112H Recombinant Human RBP4, His-tagged E.coli N/A
Human RBP4-30009TH Recombinant Human RBP4, FLAG-tagged HEK293 Flag 183 amino acids
Human RBP4-3717H Recombinant Human RBP4, His-tagged E.coli His
Human RBP4-52H Recombinant Human RBP4 Yeast N/A
Human RBP4-442H Recombinant Human RBP4 protein, His-tagged HEK293F His Ala18~Leu201
Human RBP4-836H Active Recombinant Human RBP4 protein, His-tagged HEK293 His Met1-Leu201
Human RBP4-354H Active Recombinant Human RBP4 Protein (Glu19-Leu201), C-6×His tagged NS0 C-6×His Glu19-Leu201
Human RBP4-2863HCL Recombinant Human RBP4 cell lysate Human Cell N/A
Human RBP4-738H Recombinant Human RBP4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human RBP4-781H Recombinant Human RBP4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human RBP4-1421HFL Recombinant Full Length Human RBP4 Protein, C-Flag-tagged Mammalian cells Flag
Human RBP4-3489H Recombinant Human RBP4 protein, His-tagged E.coli His 1-201 aa
Human RBP4-1866H Recombinant Human RBP4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human RBP4-46H Recombinant Human RBP4 Protein, C-8His tagged, Biotinylated HEK293 C-8His E19-L201
Human RBP4-6159H Recombinant Human RBP4 Protein (Ala18-Leu201), N-His tagged E.coli N-His Ala18-Leu201
Human RBP4-0049H Recombinant Human RBP4 Protein HEK293 cells
Human RBP4-1275H Active Recombinant Human RBP4 protein, hFc&His-tagged HEK293 hFc&His Glu19-Leu201
Human RBP4-219H Recombinant Human RBP4 Protein, His-tagged HEK293 His
Human RBP4-247H Native Human Retinol Binding Protein 4 Human Plasma N/A
Human RBP4-1866H-B Recombinant Human RBP4 Protein Pre-coupled Magnetic Beads HEK293
Human RBP4-6158H Recombinant Human RBP4 Protein (Glu19-Leu201) E.coli Tag Free Glu19-Leu201
Mouse Rbp4-447M Recombinant Mouse Rbp4, FLAG-tagged HEK293 Flag
Mouse RBP4-211M Active Recombinant Mouse RBP4 protein(Met1-Leu201), His-tagged HEK293 C-His Met1-Leu201
Mouse Rbp4-446M Recombinant Mouse Rbp4, His-tagged E.coli His
Mouse RBP4-2304MCL Recombinant Mouse RBP4 cell lysate Human Cell N/A
Mouse Rbp4-5427M Recombinant Mouse Rbp4 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat Rbp4-2388R Recombinant Rat Retinol Binding Protein 4, Plasma, FLAG-tagged HEK293 Flag
Rat Rbp4-7427R Active Recombinant Rat Rbp4 protein(Met1-Leu201), His-tagged HEK293 C-His Met1-Leu201
Rat Rbp4-448R Recombinant Rat Rbp4, His-tagged E.coli His
Rat RBP4-2271RCL Recombinant Rat RBP4 cell lysate Human Cell N/A
Rat RBP4-214R Recombinant Rat Retinol Binding Protein 4, Plasma, His-tagged Human Cell His
Rabbit RBP4-3273R Recombinant Rabbit RBP4 protein, His-tagged E.coli His Glu19~Leu201
Canine RBP4-1036C Active Recombinant Canine RBP4 protein, His-tagged HEK293 His Met1-Leu201
Canine RBP4-1035C Active Recombinant Canine RBP4 protein(Met1-Leu201), hFc-tagged HEK293 C-hFc Met1-Leu201
Canine RBP4-1517CCL Recombinant Canine RBP4 cell lysate Human Cell N/A
Cattle RBP4-1757C Recombinant Cattle RBP4 protein, His-tagged E.coli His Glu1~Leu183
Cynomolgus RBP4-112C Active Recombinant Cynomolgus RBP4, His tagged HEK293 His Met1-Leu201
Cynomolgus Monkey RBP4-1045CCL Recombinant Cynomolgus RBP4 cell lysate Human Cell N/A
Zebrafish RBP4-8561Z Recombinant Zebrafish RBP4 Mammalian Cell His
Pig RBP4-5635P Recombinant Pig RBP4 protein, His-tagged E.coli His Glu19~Leu201 (Accession # P27485)
Chicken RBP4-5634C Recombinant Chicken RBP4 protein, His-tagged E.coli His Glu22~Ser196 (Accession # P41263)
Chicken RBP4-6791C Recombinant Chicken RBP4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RBP4 Related Articles
  • RBP4 Related Research Area

RBP4 involved in several pathways and played different roles in them. We selected most pathways RBP4 participated on our site, such as Disease, Diseases associated with visual transduction, Diseases of signal transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with RBP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
DiseaseOPN1LW;EEF2;GCKR;NUP35;CTBP1;HEY1;JAG1;CUX1;LTF
Diseases associated with visual transductionRLBP1;OPN1MW2;STRA6;OPN1MW;TTR;OPN1LW;OPN1SW;RBP1;RBP4
Diseases of signal transductionFKBP1A;CCNC;TNKS;MYO18A;MIB1;CDC37;CUX1;RBP4;LRRFIP1
Retinoid cycle disease eventsRBP1;STRA6;RLBP1;RBP4
Retinoid metabolism and transportAPOC2;CLPS;APOA4B.1;AKR1C21;AKR1C6;BCO2L;APOA4A;RBP2A;RBP1
SREBP signallingINSIG1;RNF139;SEC23B;RBP4;DBI;INSIG2
Signal TransductionGMIP;PRICKLE1B;KTN1;TLE3;USP15;ADM;GPR65;KDM4C;LINGO1
The canonical retinoid cycle in rods (twilight vision)STRA6;DHRS9;RPE65A;RDH10;RPE65B;RLBP1A;RLBP1B;RDH12;SDR9C7

RBP4 has several biochemical functions, for example, protein binding, protein heterodimerization activity, retinal binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RBP4 itself. We selected most functions RBP4 had, and list some proteins which have the same functions with RBP4. You can find most of the proteins on our site.

Function Related Protein
protein bindingSOX15;COL10A1;COA3;LARP1;SMARCD3;RNF7;SUN2;TFDP2;SGCA
protein heterodimerization activityGTF2A2;TLR6;EXT2;JDP2;HIST1H2BK;BHLHE40;LIFR;H2AFVA;BOKB
retinal bindingRBP1;RBP5;RBP3;RBP2B;RBP4;RBP7;RBP2;RBP2A;CRABP1
retinol bindingRBP2;CRABP2;ADH4;RBP5;RLBP1;CRABP1;RBP3;RBP4;ADH7
retinol transporter activity

RBP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RBP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of RBP4.

TTR; TTR; GRB2; q9wmx2-pro_0000037550

Hu, ZY; Lausted, C; et al. Quantitative Liver-Specific Protein Fingerprint in Blood: A Signature for Hepatotoxicity. THERANOSTICS 4:215-228(2014).
Kotnik, P; Keuper, M; et al. Interleukin-1 beta Downregulates RBP4 Secretion in Human Adipocytes. PLOS ONE 8:-(2013).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can RBP4 levels help predict the risk of developing certain cancers? 03/02/2023

Studies have indicated a link between elevated RBP4 levels and a decreased risk of certain cancers, although more research is needed in this area.

Does RBP4 play a role in neurodegenerative diseases? 03/21/2020

Some studies suggest a potential association between RBP4 levels and neurodegenerative disorders like Alzheimer's disease.

How is RBP4 involved in pregnancy? 08/04/2017

RBP4 has been investigated in gestational diabetes, showing potential as a marker for metabolic complications during pregnancy.

Is RBP4 considered a reliable biomarker in clinical practice? 07/07/2017

While RBP4 shows promise as a biomarker, its clinical utility is still under investigation and requires further validation.

Are there gender-specific differences in RBP4 levels? 11/02/2016

Yes, research has shown that RBP4 levels can differ between genders, potentially affecting metabolic health differently.

Customer Reviews (3)

Write a review
Reviews
06/17/2022

    The manufacturer's dedicated and knowledgeable support team is readily available to address any concerns, provide guidance, and offer timely solutions.

    01/16/2022

      In addition to its impeccable quality, the manufacturer of the RBP4 protein provides outstanding technical support that can efficiently resolve any challenges encountered during my experiments.

      12/09/2019

        Such attentive support significantly minimizes potential setbacks and facilitates a seamless and efficient experimental process.

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