Recombinant Human RBP4 Protein, His-tagged

• Cat.No.: RBP4-219H
• Product Overview: Biotinylated Recombinant Human Retinol-Binding Protein 4 is produced by Human 293 Cells. The target gene encoding E19-L201 is expressed with an 8His tag at the C terminus.

Specification

• Description: Retinol-binding protein 4 (RBP4) is a prototypic member of the lipocalin superfamily. RBP4 acts as a carrier for retinol (vitamin A), can stabilize the unstable and insoluble retinol in aqueous solution through their tight interaction. RBP4 is secreted from the liver, and in turn delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP4-retinol complex interacts with transthyretin (TTR), which is crucial for preventing RBP4 excretion through the kidney glomeruli. Recently studies found that RBP4 is expressed in adipose tissue and correlated with obesity, insulin resistance (IR) and type 2 diabetes (T2DM).
• Source: HEK293
• Species: Human
• Tag: His
• Form: Lyophilized frum a 0.2 um filtered solution of PBS, pH7.2.
• Molecular Mass: Predicted Molecular Weight: 24.1kDa
  Apparent Molecular Weight: Biotinylated RBP4 protein appeared at 24kDa and 26kDa in a reducing SDS-PAGE gel.
• AA Sequence: E19-L201
• Endotoxin: Less than 0.1 EU/ug.
• Purity: >95%
• Storage: Lyophilized protein should be stored at < -20 centigrade, though stable at room temperature for 3 weeks.
  Reconstituted protein solution can be stored at 4-7 centigrade for 2-7 days. Aliquots of reconstituted samples are stable at < -20 centigrade for 3 months.
  Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
• Reconstitution: It is not recommended to reconstitute to a concentration less than 100μg/ml.
  Dissolve the lyophilized protein in distilled water.
  Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Quality Statement: Purity: greater than 95% as determined by reducing SDS-PAGE.
• Shipping: The product is shipped on dry ice pack.
  Upon receipt, store it immediately at the temperature listed below.

Gene Information

• Gene Name: RBP4 retinol binding protein 4 [ Homo sapiens (human) ]
• Official Symbol: RBP4
• Synonyms: Plasma retinol-binding protein; retinol binding protein 4, plasma; RetinolBinding Protein 4; retinol-binding protein 4; RDCCAS; MCOPCB10
• Gene ID: 5950
• mRNA Refseq: NM_001323517.
• Protein Refseq: NP_001310446.1
• MIM: 180250
• UniProt ID: P02753

Reviews

06/17/2022

The manufacturer's dedicated and knowledgeable support team is readily available to address any concerns, provide guidance, and offer timely solutions.

01/16/2022

In addition to its impeccable quality, the manufacturer of the RBP4 protein provides outstanding technical support that can efficiently resolve any challenges encountered during my experiments.

12/09/2019

Such attentive support significantly minimizes potential setbacks and facilitates a seamless and efficient experimental process.

Q&As

Can RBP4 levels help predict the risk of developing certain cancers?

Studies have indicated a link between elevated RBP4 levels and a decreased risk of certain cancers, although more research is needed in this area.

Does RBP4 play a role in neurodegenerative diseases?

Some studies suggest a potential association between RBP4 levels and neurodegenerative disorders like Alzheimer's disease.

How is RBP4 involved in pregnancy?

RBP4 has been investigated in gestational diabetes, showing potential as a marker for metabolic complications during pregnancy.

Is RBP4 considered a reliable biomarker in clinical practice?

While RBP4 shows promise as a biomarker, its clinical utility is still under investigation and requires further validation.

Are there gender-specific differences in RBP4 levels?

Yes, research has shown that RBP4 levels can differ between genders, potentially affecting metabolic health differently.