Recombinant Human RBP4, FLAG-tagged

• Cat.No.: RBP4-30009TH
• Product Overview: Recombinant full length Human RBP4 fused at the N terminus to a DDDDK tag; mwt: 23 kDa.

Specification

• Description: This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells.
• Protein length: 183 amino acids
• Conjugation: FLAG
• Molecular Weight: 23.000kDa
• Source: HEK 293 cells
• Form: Liquid
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: PBS, pH 7.2
• Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
• Sequence Similarities: Belongs to the calycin superfamily. Lipocalin family.

Gene Information

• Gene Name: RBP4 retinol binding protein 4, plasma [ Homo sapiens ]
• Official Symbol: RBP4
• Synonyms: RBP4; retinol binding protein 4, plasma; retinol-binding protein 4
• Gene ID: 5950
• mRNA Refseq: NM_006744
• Protein Refseq: NP_006735
• Uniprot ID: P02753
• Chromosome Location: 10q23-q24
• Pathway: Vitamin A and carotenoid metabolism, organism-specific biosystem
• Function: protein binding; retinal binding; retinol binding; retinol transporter activity; transporter activity

Reviews

06/17/2022

The manufacturer's dedicated and knowledgeable support team is readily available to address any concerns, provide guidance, and offer timely solutions.

01/16/2022

In addition to its impeccable quality, the manufacturer of the RBP4 protein provides outstanding technical support that can efficiently resolve any challenges encountered during my experiments.

12/09/2019

Such attentive support significantly minimizes potential setbacks and facilitates a seamless and efficient experimental process.

Q&As

Can RBP4 levels help predict the risk of developing certain cancers?

Studies have indicated a link between elevated RBP4 levels and a decreased risk of certain cancers, although more research is needed in this area.

Does RBP4 play a role in neurodegenerative diseases?

Some studies suggest a potential association between RBP4 levels and neurodegenerative disorders like Alzheimer's disease.

How is RBP4 involved in pregnancy?

RBP4 has been investigated in gestational diabetes, showing potential as a marker for metabolic complications during pregnancy.

Is RBP4 considered a reliable biomarker in clinical practice?

While RBP4 shows promise as a biomarker, its clinical utility is still under investigation and requires further validation.

Are there gender-specific differences in RBP4 levels?

Yes, research has shown that RBP4 levels can differ between genders, potentially affecting metabolic health differently.