Recombinant Human RBP4 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: RBP4-781H
• Product Overview: RBP4 MS Standard C13 and N15-labeled recombinant protein (NP_006735) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 23 kDa
• AA Sequence: MKWVWALFLLAALGSGRAERDCRVS SFRVKENFDKARFSGTWYAMAKKDP EGLFLQDNIVAEFSVDETGQMSATA KGRVRLLNNWDVCADMVGTFTDTED PAKFKMKYWGVASFLQKGNDDHWIV DTDYDTYAVQYSCRLLNLDGTCADS YSFVFSRDPNGLPPEAQKIVRQRQE ELCLARQYRLIVHNGYCDGRSERNL LTRTRPLEQKLISEEDLAANDILDY KDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: RBP4 retinol binding protein 4 [ Homo sapiens (human) ]
• Official Symbol: RBP4
• Synonyms: RBP4; retinol binding protein 4, plasma; retinol-binding protein 4; RBP; PRBP; plasma retinol-binding protein; retinol-binding protein 4, interstitial
• Gene ID: 5950
• mRNA Refseq: NM_006744
• Protein Refseq: NP_006735
• MIM: 180250
• UniProt ID: P02753

Reviews

06/17/2022

The manufacturer's dedicated and knowledgeable support team is readily available to address any concerns, provide guidance, and offer timely solutions.

01/16/2022

In addition to its impeccable quality, the manufacturer of the RBP4 protein provides outstanding technical support that can efficiently resolve any challenges encountered during my experiments.

12/09/2019

Such attentive support significantly minimizes potential setbacks and facilitates a seamless and efficient experimental process.

Q&As

Can RBP4 levels help predict the risk of developing certain cancers?

Studies have indicated a link between elevated RBP4 levels and a decreased risk of certain cancers, although more research is needed in this area.

Does RBP4 play a role in neurodegenerative diseases?

Some studies suggest a potential association between RBP4 levels and neurodegenerative disorders like Alzheimer's disease.

How is RBP4 involved in pregnancy?

RBP4 has been investigated in gestational diabetes, showing potential as a marker for metabolic complications during pregnancy.

Is RBP4 considered a reliable biomarker in clinical practice?

While RBP4 shows promise as a biomarker, its clinical utility is still under investigation and requires further validation.

Are there gender-specific differences in RBP4 levels?

Yes, research has shown that RBP4 levels can differ between genders, potentially affecting metabolic health differently.