Recombinant Human RBP4, His-tagged

• Cat.No.: RBP4-112H
• Product Overview: Recombinant Human RBP-4 produced inE.Coliis a single, non-glycosylated, polypeptide chain containing 204 amino acids and having a molecular mass of 23 kDa. RBP4 is fused to N-terminus His tag which containes additional 21 amino acids. RBP4 sequence is identical to UniProtKB/Swiss-Prot entry Q5VY30 amino acids 16–199. The Retinol Binding Protein-4 is purified by proprietary chromatographic techniques.

Specification

• Cat. No.: RBP4-112H
• Description: Retinol binding protein 4(RBP4) belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. This protein was found to be expressed and secreted by adipose tissue, and was strongly associated with insulin resistance. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. RBP4 delivers retinol from the liver to the peripheral tissues. In plasma, the rbp-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
• Source: Escherichia Coli.
• Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
• Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
• Formulation: RBP-4 His tag was lyophilized from a concentrated (0.5mg/ml) solution containing PBS pH-7.5.
• Solubility: It is recommended to reconstitute the lyophilizedRetinol binding protein-4 in sterile deionized water to a working volume of 0.5 mg/mL and let the lyophilized pellet dissolve completely
• Amino acid sequence: MSWWHHHHHH NWNIPTTQDT TERDCRVSSF RVKENFDKAR FSGTWYAMAK KDPEGLFLQD NIVAEFSVDE TGQMSATAKG RVRLLNNWDV CADMVGTFTD TEDPAKFKMK YWGVASFLQK GNDDHWIVDT DYDTYAVQYS CRLLNLDGTC ADSYSFVFSR DPNGLPPEAQ KIVRQRQEEL CLARQYRLIV HNGYCDGRSE RNLL.
• Storage: Lyophilized Retinol binding protein-4 although stable at room temperature for 3 weeks, should be stored desiccated below -18℃. Upon reconstitution Retinol binding protein-4 should be stored at 4℃ between 2-7 days and for future use below -18℃. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Gene Information

• Gene Name: RBP4 retinol binding protein 4, plasma [ Homo sapiens ]
• Synonyms: Retinol Binding Protein 4; RBP-4; RBP4; Plasma retinol-binding protein; PRBP; RBP; OTTHUMP00000020114; OTTHUMP00000020116; retinol binding protein 4, plasma; retinol-binding protein 4, interstitial.
• Gene ID: 5950
• mRNA Refseq: NM_006744
• Protein Refseq: NP_006735
• MIM: 180250
• UniProt ID: P02753
• Chromosome Location: 10q23-q24
• Function: binding; retinal binding; retinol binding; retinol transporter activity; transporter activity

Reviews

06/17/2022

The manufacturer's dedicated and knowledgeable support team is readily available to address any concerns, provide guidance, and offer timely solutions.

01/16/2022

In addition to its impeccable quality, the manufacturer of the RBP4 protein provides outstanding technical support that can efficiently resolve any challenges encountered during my experiments.

12/09/2019

Such attentive support significantly minimizes potential setbacks and facilitates a seamless and efficient experimental process.

Q&As

Can RBP4 levels help predict the risk of developing certain cancers?

Studies have indicated a link between elevated RBP4 levels and a decreased risk of certain cancers, although more research is needed in this area.

Does RBP4 play a role in neurodegenerative diseases?

Some studies suggest a potential association between RBP4 levels and neurodegenerative disorders like Alzheimer's disease.

How is RBP4 involved in pregnancy?

RBP4 has been investigated in gestational diabetes, showing potential as a marker for metabolic complications during pregnancy.

Is RBP4 considered a reliable biomarker in clinical practice?

While RBP4 shows promise as a biomarker, its clinical utility is still under investigation and requires further validation.

Are there gender-specific differences in RBP4 levels?

Yes, research has shown that RBP4 levels can differ between genders, potentially affecting metabolic health differently.