CD44
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Official Full Name
CD44 molecule (Indian blood group)
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Overview
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008] -
Synonyms
CD44; CD44 molecule (Indian blood group); IN; LHR; MC56; MDU2; MDU3; MIC4; Pgp1; CDW44; CSPG8; HCELL; HUTCH-I; ECMR-III; CD44 antigen; epican; Hermes antigen; hyaluronate receptor; phagocytic glycoprotein 1; heparan sulfate proteoglycan; cell surface glycoprotein CD44; extracellular matrix receptor III; chondroitin sulfate proteoglycan 8; GP90 lymphocyte homing/adhesion receptor; hematopoietic cell E- and L-selectin ligand; homing function and Indian blood group system;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus)
- Human
- Mouse
- Mus musculus (Mouse)
- Papio hamadryas (Hamadryas baboon)
- Rabbit
- Rat
- Rattus norvegicus (Rat)
- CHO
- E.coli
- E.coli expression system
- HEK293
- HEK293F
- HEK293T
- Human Cell
- Human Cells
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- DYKDDDDK
- Fc
- Flag
- GST
- hFc
- His (Fc)
- Avi
- Strep
- His|SUMO
- SUMO
- human|IgG1|Fc
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- CD44 Related Articles
- CD44 Related Research Area
- CD44 Related Signal Pathway
CD44 involved in several pathways and played different roles in them. We selected most pathways CD44 participated on our site, such as ECM-receptor interaction, Hematopoietic cell lineage, Shigellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD44 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ECM-receptor interaction | CD47;ITGB1A;FN1;COL1A2;LAMC3;CHAD;ITGAV;ITGB6;VTNA |
Hematopoietic cell lineage | Il4ra;CD9;IL7R;THPO;FCGR1;KITLG;CD8B1;ANPEP;IL4 |
Shigellosis | RELA;IL-8;FBXW11;ELMO2;IKBKB;BTRC;U2AF1;MAPK3;PFN4 |
Epstein-Barr virus infection | MAP2K6;EIF2AK3;SPN;YWHAE;HDAC2;PSMC6;HLA-DQA2;POLR3B;CSNK2B |
Proteoglycans in cancer | THBS1;LUM;ANK2;ERBB3;WNT9A;WNT3;ERBB4;PDCD4;PIK3CB |
MicroRNAs in cancer | CCND2;NOTCH4;CD44;Pdgfa&Pdgfb;SERPINB5;PRKCE;TPM1;PLCG1;BAK1 |
CD44 has several biochemical functions, for example, collagen binding, contributes_to cytokine receptor activity, hyaluronic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD44 itself. We selected most functions CD44 had, and list some proteins which have the same functions with CD44. You can find most of the proteins on our site.
Function | Related Protein |
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collagen binding | PDGFB;Itga10&Itgb1;NID1;DDR1;CTSK;CTSS;LRRC15;LUM;PODN |
contributes_to cytokine receptor activity | IL28RA;CD44;IRX1 |
hyaluronic acid binding | HAPLN4;NCAN;BCAN;HAPLN2;CD44;VCANB;VCAN;STAB2;HAPLN3 |
hyalurononglucosaminidase activity | KIAA1199;HYAL1;HYAL3;HYAL6;SPAM1;MGEA5;HYAL4;HYAL2;CD44 |
protein binding | SYMPK;KRTAP3-3;VANGL1;CDC37L1;ADAM1B;TMEM119;LNX2B;BTK;NUP62CL |
CD44 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD44 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD44.
ipaB; SPP1; ganglioside_gm1; SLC7A11; MSN
- Q&As
- Reviews
Q&As (7)
Ask a questionCD44 is implicated in cancer progression and metastasis. It promotes tumor cell invasion, migration, and adhesion to the extracellular matrix. CD44 also plays a role in cancer stem cell maintenance and drug resistance. Its overexpression is associated with poor prognosis in various types of cancer.
Targeting CD44 has been explored as a potential therapeutic strategy in cancer and inflammatory diseases. Strategies include blocking CD44-ligand interactions, inhibiting CD44 signaling pathways, and targeting CD44-positive cancer stem cells. However, further research is needed to fully understand the complex roles of CD44 in different disease contexts and to develop effective CD44-targeted therapies.
The expression of CD44 is regulated at multiple levels, including transcriptional control, alternative splicing, and post-translational modifications. Transcription factors such as Sp1 and NF-κB can bind to the CD44 promoter region to regulate its gene expression. Additionally, alternative splicing of CD44 pre-mRNA generates CD44 isoforms with different functions and expression patterns.
CD44 is involved in immune cell activation, trafficking, and homing. It participates in the recruitment of leukocytes to sites of inflammation and mediates T cell adhesion and migration. CD44 can also modulate immune responses by interacting with other immune receptors and cytokines, and it is involved in the regulation of T cell activation and differentiation.
CD44 plays a vital role in immune regulation by participating in immune cell activation, migration, and modulation of T-cell activation and differentiation. CD44 is expressed on various immune cell populations, including T cells, B cells, natural killer cells, and dendritic cells. It serves as an adhesion molecule and facilitates immune cell trafficking to lymphoid tissues and inflammatory sites. CD44 also functions as a co-stimulatory receptor, enhancing T-cell activation and cytokine production upon interaction with its ligands. Moreover, CD44 isoforms have been implicated in the differentiation of T helper cell subsets, such as Th1, Th2, and Th17 cells. These findings highlight the multifaceted role of CD44 in immune regulation and its potential as a therapeutic target for immune-related disorders.
CD44 is a transmembrane glycoprotein predominantly localized on the cell surface, specifically in the plasma membrane of various cell types, including epithelial cells, leukocytes, and mesenchymal cells.
CD44 can activate various signaling pathways, including PI3K/AKT, MAPK/ERK, and NF-κB pathways. These pathways mediate downstream cellular processes such as cell survival, proliferation, migration, and immune responses. CD44 can also interact with other cell surface receptors, such as receptor tyrosine kinases, to modulate their signaling activities.
Customer Reviews (3)
Write a reviewUsing this reagent, I can gain a better understanding of the functionality and regulatory mechanisms of proteins.
This reagent has long-lasting performance, enduring prolonged experimental use.
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