Recombinant Human CD44 Protein (21-606 aa), His-SUMO-tagged

• Cat.No.: CD44-393H
• Product Overview: Recombinant Human CD44 Protein (21-606 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Protein Description: Partial.

Specification

• Description: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hatopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
• Source: E. coli
• Species: Human
• Tag: His-SUMO
• Form: Tris-based buffer, 50% glycerol
• Molecular Mass: 80.2 kDa
• Protein length: 21-606 aa
• AA Sequence: QIDLNITCRFAGVFHVEKNGRYSIS RTEAADLCKAFNSTLPTMAQMEKAL SIGFETCRYGFIEGHVVIPRIHPNS ICAANNTGVYILTSNTSQYDTYCFN ASAPPEEDCTSVTDLPNAFDGPITI TIVNRDGTRYVQKGEYRTNPEDIYP SNPTDDDVSSGSSSERSSTSGGYIF YTFSTVHPIPDEDSPWITDSTDRIP ATSTSSNTISAGWEPNEENEDERDR HLSFSGSGIDDDEDFISSTISTTPR AFDHTKQNQDWTQWNPSHSNPEVLL QTTTRMTDVDRNGTTAYEGNWNPEA HPPLIHHEHHEEEETPHSTSTIQAT PSSTTEETATQKEQWFGNRWHEGYR QTPREDSHSTTGTAAASAHTSHPMQ GRTTPSPEDSSWTDFFNPISHPMGR GHQAGRRMDMDSSHSTTLQPTANPN TGLVEDLDRTGPLSMTTQQSNSQSF STSHEGLEEDKDHPTTSTLTSSNRN DVTGGRRDPNHSEGSTTLLEGYTSH YPHTKESRTFIPVTSAKTGSFGVTA VTVGDSNSNVNRSLSGDQDTFHPSG GSHTTHGSESDGHSHGSQEGGANTT SGPIRTPQIPE
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with concentration instruction is sent along with the products.

Gene Information

• Gene Name: CD44 CD44 molecule (Indian blood group) [ Homo sapiens ]
• Official Symbol: CD44
• Synonyms: CD44; CD44 antigen; CD44R; CSPG8; HCELL; IN; MC56; Pgp1; epican; LHR; MDU2; MDU3; MIC4; CDW44; HUTCH-I; ECMR-III; MGC10468
• Gene ID: 960
• mRNA Refseq: NM_000610
• Protein Refseq: NP_000601
• MIM: 107269
• UniProt ID: P16070