ILF3
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Official Full Name
interleukin enhancer binding factor 3, 90kDa
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Overview
This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein was first discovered to be a subunit of the nuclear factor of activated T-cells (NFAT); a transcription factor required for T-cell expression of interleukin 2. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the larger of which is the product of this gene. These proteins have been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth; possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms. -
Synonyms
ILF3; interleukin enhancer binding factor 3, 90kDa; interleukin enhancer binding factor 3, 90kD; interleukin enhancer-binding factor 3; DRBP76; M phase phosphoprotein 4; MPHOSPH4; MPP4; NF90; NFAR 1; M-phase phosphoprotein 4; translational control protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- His|T7
- Myc
- DDK
- MYC
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
ILF3 involved in several pathways and played different roles in them. We selected most pathways ILF3 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ILF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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ILF3 has several biochemical functions, for example, DNA binding, RNA binding, double-stranded RNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ILF3 itself. We selected most functions ILF3 had, and list some proteins which have the same functions with ILF3. You can find most of the proteins on our site.
Function | Related Protein |
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DNA binding | ZNF473;TNP2;DHX9;LBX2;CENPW;ZNF766;RAD52;SP110;SP4 |
RNA binding | APOBEC3G;MBNL1;PTBP1;MPHOSPH6;SPI1;RPL38;RBM46;SRSF9;PAPOLA |
double-stranded RNA binding | RFTN1;ZNF346;ILF2;BARHL1;YRDC;AGO1;TLR8;DGCR8;OAS3 |
poly(A) RNA binding | PSMC1;FAM103A1;H2-Q10;PRPF3;UBFD1;ROCK2;PSIP1;MRPL28;HNRNPU |
protein binding | CWC22;ETS1;PLEKHA1;BEND3;HESX1;C16orf79;ACBD3;TSEN2;ID3 |
ILF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ILF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ILF3.
YBX1; ILF2; VP35; PRMT1; VCAM1
- Q&As
- Reviews
Q&As (6)
Ask a questionThis is associated with a variety of tumors, including breast cancer, lung cancer, and colon cancer. In tumor development, ILF3 may promote cell proliferation, apoptosis inhibition, and metastasis.
At present for ILF3 new treatment for cancer and new drug exploration is still in its infancy, but some ILF3 related drugs and treatment strategies are in development and evaluation, bring new hope for patients.
This peotein may be associated with tumor microenvironment and immune escape, and can regulate the interaction between tumor cells and immune cells, further deepening our understanding of the mechanism of immune escape.
The association between ILF3 and tumor prognosis and treatment response needs to be further studied, but according to the current study, high expression of ILF3 may be associated with poor prognosis and drug resistance in cancer patients.
ILF3 may play an important immunomodulatory function in infectious diseases and may be involved in the immune response and inflammatory response caused by viral or bacterial infection.
It may play an important role in autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus (sle), may be involved in these diseases by means of immune regulation of occurrence and development.
Customer Reviews (3)
Write a reviewThe impurities are not obvious, clear and transparent, and the purity is high.
It can meet the needs of daily experiments, and the expression effect is good.
ILF3 has performed well in experiments and is a reliable choice.
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