Recombinant Human ILF3 protein, His & T7-tagged
Cat.No. : | ILF3-2710H |
Product Overview : | Recombinant Human ILF3 aa. (Tyr672~Tyr891 (Accession # Q12906)) fused with N-terminal His & T7 tag was produced in E. coli cells. |
- Specification
- Gene Information
- Related Products
- Download
Description : | This gene encodes a double-stranded RNA (dsRNA) binding protein that complexes with other proteins, dsRNAs, small noncoding RNAs, and mRNAs to regulate gene expression and stabilize mRNAs. This protein (NF90, ILF3) forms a heterodimer with a 45 kDa transcription factor (NF45, ILF2) required for T-cell expression of interleukin 2. This complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. In contrast, an isoform (NF110) of this gene that is predominantly restricted to the nucleus has only minor effects on cell growth when its levels are reduced. Alternative splicing results in multiple transcript variants encoding distinct isoforms. |
Source : | E. coli |
Species : | Human |
Tag : | His & T7 |
Form : | Freeze-dried powder |
Molecular Mass : | Predicted Molecular Mass: 26.0kDa |
Protein length : | Tyr672~Tyr891 (Accession # Q12906) |
Endotoxin : | <1.0EU per 1µg (determined by the LAL method) |
Purity : | >95% |
Characteristic : | The isoelectric point is 9.3. |
Applications : | SDS-PAGE; WB; ELISA; IP |
Stability : | The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition. |
Storage : | Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months. |
Storage buffer : | Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl. |
Reconstitution : | Reconstitute in sterile PBS, pH7.2-pH7.4. |
Gene Name : | ILF3 interleukin enhancer binding factor 3 [ Homo sapiens (human) ] |
Official Symbol : | ILF3 |
Synonyms : | CBTF; DRBF; MMP4; MPP4; NF90; NFAR; NF110; NF90a; NF90b; NFAR2; TCP80; DRBP76; NF110b; NFAR-1; TCP110; MPHOSPH4; NF-AT-90; M-phase phosphoprotein 4; double-stranded RNA-binding protein, 76 kD; dsRNA binding protein NFAR-2/MPP4; interleukin enhancer binding factor 3, 90kD; interleukin enhancer binding factor 3, 90kDa; nuclear factor associated with dsRNA; nuclear factor of activated T-cells 90 kDa; nuclear factor of activated T-cells, 90 kD; translational control protein 80; interleukin enhancer-binding factor 3 |
Gene ID : | 3609 |
mRNA Refseq : | NM_001137673.1 |
Protein Refseq : | NP_001131145.1 |
UniProt ID : | Q12906 |
Products Types
◆ Recombinant Protein | ||
ILF3-4524M | Recombinant Mouse ILF3 Protein, His (Fc)-Avi-tagged | +Inquiry |
ILF3-2707R | Recombinant Rat ILF3 Protein, His (Fc)-Avi-tagged | +Inquiry |
ILF3-1182H | Recombinant Human ILF3 Protein, His (Fc)-Avi-tagged | +Inquiry |
Ilf3-1248M | Recombinant Mouse Ilf3 Protein, MYC/DDK-tagged | +Inquiry |
ILF3-5160H | Recombinant Human ILF3 Protein, GST-tagged | +Inquiry |
◆ Lysates | ||
ILF3-5221HCL | Recombinant Human ILF3 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (6)
Ask a questionThis is associated with a variety of tumors, including breast cancer, lung cancer, and colon cancer. In tumor development, ILF3 may promote cell proliferation, apoptosis inhibition, and metastasis.
At present for ILF3 new treatment for cancer and new drug exploration is still in its infancy, but some ILF3 related drugs and treatment strategies are in development and evaluation, bring new hope for patients.
This peotein may be associated with tumor microenvironment and immune escape, and can regulate the interaction between tumor cells and immune cells, further deepening our understanding of the mechanism of immune escape.
The association between ILF3 and tumor prognosis and treatment response needs to be further studied, but according to the current study, high expression of ILF3 may be associated with poor prognosis and drug resistance in cancer patients.
ILF3 may play an important immunomodulatory function in infectious diseases and may be involved in the immune response and inflammatory response caused by viral or bacterial infection.
It may play an important role in autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus (sle), may be involved in these diseases by means of immune regulation of occurrence and development.
Customer Reviews (3)
Write a reviewThe impurities are not obvious, clear and transparent, and the purity is high.
It can meet the needs of daily experiments, and the expression effect is good.
ILF3 has performed well in experiments and is a reliable choice.
Ask a Question for All ILF3 Products
Required fields are marked with *
My Review for All ILF3 Products
Required fields are marked with *
Inquiry Basket