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INS

  • Official Full Name

    insulin

  • Overview

    After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5 region and with the IGF2 gene at the 3 region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010] After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants.
  • Synonyms

    INS; insulin; ILPR; IRDN; IDDM1; IDDM2; MODY10; proinsulin; preproinsulin; insulin-dependent diabetes mellitus 2; OTTHUMP00000011161; OTTHUMP00000011162; OTTHUMP00000196036; OTTHUMP00000196038; OTTHUMP00000217519;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • Therapeutic Proteins
  • Native Proteins
  • Beef
  • Bovine
  • Cattle
  • Chicken
  • Cynomolgus Monkey
  • Guinea pig
  • Horse
  • Human
  • Mouse
  • Pig
  • Pongo pygmaeus
  • Rabbit
  • S.cerevisiae
  • Zebrafish
  • Beef Pancreas
  • Bovine pancreas
  • E.coli
  • HEK293
  • Human
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Porcine Pancreas
  • S.cerevisiae
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • His|SUMO
  • Met|His|Lys
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human INS-607H Active Recombinant Human INS, Met, His&Lys-tagged E.coli Met/His/Lys
Human INS-320H Active Recombinant Human INS Yeast N/A Phe1-Lys29 & Gly1-Asn21
Human INS-88H Active Recombinant Human INS, His-tagged E.coli His
Human INS-14H Active Recombinant Human Insulin, Low Endotoxin, Media Grade E.coli N/A
Human INS-315H Recombinant Human Proinsulin protein E.coli N/A
Human INS-5308H Recombinant Human Insulin E.coli N/A
Human INS-674H Recombinant Human INS Protein, His/GST-tagged E.coli His/GST Phe25~Asn110
Human INS-321 Synthesis Human Proinsulin C-Peptide (55-89), bioactive peptide hormone N/A
Human INS-341H Recombinant Human INS Mammalian Cell His
Human INS-5195HCL Recombinant Human INS 293 Cell Lysate HEK293 N/A
Human INS-5100H Recombinant Human INS Protein, GST-tagged Wheat Germ GST
Human INS-191HFL Active Recombinant Full Length Human INS Protein, C-Flag-tagged Mammalian cells Flag
Human INS-29H Recombinant Human INS protein E.coli N/A 35
Human INS-194H Human Proinsulin Reference standard N/A
Human INS-856H Recombinant Human INS Protein, His-tagged E.coli His
Human INS-1187H-B Recombinant Human INS Protein Pre-coupled Magnetic Beads HEK293
Human INS-61H Recombinant Human INS Protein E.coli
Human Insulin-P060H Recombinant Human INS therapeutic protein S.cerevisiae N/A
Human INS-1759H Recombinant Human INS protein, His & GST-tagged E.coli His/GST Phe25~Asn110
Human INS-0301H Active Recombinant Human INS protein Yeast N/A Phe25-Lys53 & Gly90-Asn110
Human INS-1187H Recombinant Human INS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human INS-321H Recombinant Human INS protein Yeast N/A Phe25-Lys53
Human INS-69H Human Insulin Reference standard N/A
Human INS-2368H Recombinant Human INS Protein (Phe25-Thr54, Gly90-Thr110), N-His tagged E.coli N-His Phe25-Thr54, Gly90-Thr110
Human Insulin-P039H Recombinant Human INS therapeutic protein N/A
Human INS-60H Recombinant Human INS Protein E.coli
Human Insulin-P061H Recombinant Human INS therapeutic protein E.coli N/A
Human INS-2369H Recombinant Human INS Protein (Phe25-Asn110), N-GST tagged E.coli N-GST Phe25-Asn110
Human Insulin-P057H Recombinant Human INS therapeutic protein E.coli N/A 32aa
Human INS-5978HF Recombinant Full Length Human INS Protein, GST-tagged In Vitro Cell Free System GST 110 amino acids
Human Insulin-P056H Recombinant Human INS therapeutic protein E.coli N/A 32aa
Human INS-P040H Recombinant Human INS therapeutic protein E.coli N/A 30 aa
Human INS-53H Active Recombinant Human INS Protein Yeast
Mouse INS-561M Recombinant Mouse INS protein, His-tagged E.coli His Phe25~Ser54 and Gly90~Asn110 linked by GGGGS
Rabbit INS-679R Recombinant Rabbit INS Protein, His/GST-tagged E.coli His/GST Phe25~Asn110
Rabbit INS-4330R Recombinant Rabbit INS protein E.coli N/A 25-54aa
Beef INS-512D Native Bovine INS Beef Pancreas N/A
Bovine INS-193B Bovine Proinsulin Reference standard N/A
Bovine INS-72B Bovine Insulin Reference standard N/A
Bovine INS-5435B Native Bovine Insulin Bovine pancreas N/A
Cattle INS-673C Recombinant Cattle INS Protein, His/GST-tagged E.coli His/GST Phe25~Ala54
Cattle INS-560C Recombinant Cattle INS protein, His & GST-tagged E.coli His/GST Phe25~Ala54
Cynomolgus Monkey INS-623C Recombinant Cynomolgus INS Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey INS-369C Recombinant Cynomolgus Monkey INS Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey INS-369C-B Recombinant Cynomolgus Monkey INS Protein Pre-coupled Magnetic Beads HEK293
Guinea pig Ins-1783G Recombinant Guinea pig Ins protein, His & SUMO-tagged E.coli His/SUMO Phe25~Asn110
Horse INS-1135H Recombinant Horse INS protein, GST-tagged E.coli GST 1-30aa
Pongo pygmaeus INS-64P Recombinant Pongo pygmaeus INS1 Protein E.coli
S.cerevisiae INS-256H Active Recombinant Human Insulin Human N/A
Zebrafish INS-8684Z Recombinant Zebrafish INS Mammalian Cell His
Pig INS-41P Porcine Insulin Porcine Pancreas N/A
Pig INS-676P Recombinant Pig INS Protein, His/GST-tagged E.coli His/GST Gly88~Asn108
Pig INS-677P Recombinant Pig INS Protein, His/GST-tagged E.coli His/GST Phe25~Ala54
Pig INS-74P Porcine Insulin Reference standard N/A
Chicken INS-6775C Recombinant Chicken INS Mammalian Cell His
Chicken INS-2689C Recombinant Chicken INS Protein, His-tagged E.coli N-His Ala25-Ala54+GGGGS+Gly87-Asn107
  • Involved Pathway
  • Protein Function
  • Interacting Protein

INS involved in several pathways and played different roles in them. We selected most pathways INS participated on our site, such as Ras signaling pathway, Rap signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with INS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ras signaling pathwayRASA4;Kitl;ABL1;MAPK8;LOC608458;GNB3;GRIN2A;FIGF;PAK2
Rap signaling pathwayCALM4;GRIN1;BRAF;KIT;MAP2K3;ITGA2B;KITLG;PIK3CB;Fgf15
cGMP-PKG signaling pathwayCREB3L1;PRKG1;NPPB;NOS3;ATP2A1;ATP1B3;PIK3CD;KCNJ8;INS1
HIF- signaling pathwayALDOA;EP300;TF;NOS2;PFKL;IGF1R;EPO;TCEB1;IGF1
FoxO signaling pathwayFOXO3;FBXO25;STAT3;IRS4;PLK1;SGK1;PRKAB1A;MAPK10;G6PC3
Phospholipase D signaling pathwayCYTH2;Pdgfa&Pdgfb;DNM3;INS1;AGPAT3;RHOA;PIK3R3;PLA2G4D;MRAS
Oocyte meiosisPPP2R5E;CDC26;PPP3CB;PRKACBA;PRKACAA;CALM2;RPS6KA3B;YWHAE1;CPEB3
Regulation of autophagyGABARAPA;IFNPHI1;ATG16L1;IFNA13;IFNA8;IFNA12;IFNG1-2;ATG13;IFNG
mTOR signaling pathwayBRAF;PRKAA2;ULK3;PIK3R5;PTENA;PRKAA1;VEGFA;MLST8;RPS6KB1
PIK-Akt signaling pathwayCOL6A5;ITGA10;ANGPT4;CCNE1;Il2;GH2;ITGA5;GNG12;CRTC2
AMPK signaling pathwayIGF1R;Scd1;ADIPOR1;LEPR;FBP1;IRS1;PIK3CB;CAMKK1;HNF4A
Regulation of actin cytoskeletonITGA7;RAC1A;Fgf15;INSRR;CYFIP2;HRASB;FGF6;FGF8A;FGD3
Insulin signaling pathwayMAP2K2;PRKAB1A;PCK1;PPARGC1A;AKT3A;PRKAA1;TSC1;PRKAR1A;PIK3CG
Insulin secretionATP1A1;PRKACA;ATP1A2;PLCB4;CAMK2B;GNA11;SLC2A1;GCG;PLCB1
Ovarian steroidogenesisINS2;STAR;HSD3B4;PLA2G4C;HSD3B1;SCARB1;HSD3B5;HSD3B2;AKR1C3
Progesterone-mediated oocyte maturationAdcy4;CDC27;HSP90AA1.2;RPS6KA3;ADCY1A;GNAIA;ADCY1B;ANAPC5;IGF1RB
Prolactin signaling pathwayPIK3R5;SOCS3;PIK3CD;ELF5;SOCS5;NRAS;AKT1;KRAS;MAPK11
Regulation of lipolysis in adipocytesPNPLA2;AKT1;GNAI2;PTGER3;Adcy4;PRKG1;INS;PLIN1;PIK3CD
Type II diabetes mellitusIKBKB;PIK3CG;SLC2A4;PIK3CB;MAPK8;ADIPOQ;HK3;SOCS4;HK1
Insulin resistanceSREBF1;SLC27A5;PPP1CB;G6PCA.1;INSR;PIK3R3A;FOXO1;PRKAB1B;AKT2
Non-alcoholic fatty liver disease (NAFLD)FASLG;MAPK8;INS1;ADIPOR2;RELA;NDUFA3;PRKAG1;PPARA;NDUFA1
Type I diabetes mellitusHLA-DMA;FAS;HLA-DOB;HSPD1;Il2;CPE;HLA-DMB;FASLG;GAD2
Maturity onset diabetes of the youngHNF1A;MNX1;HNF4G;PKLR;HES1;HNF4A;INS1;NR5A2;NKX6
Aldosterone-regulated sodium reabsorptionATP1A3;IGF1;FXYD2;SFN;PIK3R3;PRKCB;INSR;INS1;ATP1A4
Prostate cancerGRB2;NRAS;BRAF;TCF7L2;SMARCA4;EP300;MAPK3;IKBKG;INS

INS has several biochemical functions, for example, hormone activity, identical protein binding, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INS itself. We selected most functions INS had, and list some proteins which have the same functions with INS. You can find most of the proteins on our site.

Function Related Protein
hormone activityPRL7B1;PTHLHA;FAM132A;PRL2;FNDC5B;INS;PRL3B1;PTH1B;URP2
identical protein bindingSCUBE1;ETNPPL;PLDN;LCK;GRB7;ALK;SHANK1;APOA1;SDCBP
insulin receptor bindingPTPN11;DOK6;IGF2;PDPK1;SNX2;DOK3;SNX4;FRS3;INS1
insulin-like growth factor receptor bindingGNAS;INS;SOCS1;REN;IGF2A;INSL4;SHC1;IGF3;IGF2B
protease bindingSERPINA1E;LDLR;CSTA;BRCA2;INSL3;TIMP2;NDUFS7;ECM1;BDKRB2
protein bindingMYO5A;P2RX4;FAM153C;FBXW8;C1orf109;PEX12;MED19;CUTA;CCDC22

INS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INS here. Most of them are supplied by our site. Hope this information will be useful for your research of INS.

DCN; MAPK6

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