INS
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Official Full Name
insulin
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Overview
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5 region and with the IGF2 gene at the 3 region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010] After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. -
Synonyms
INS; insulin; ILPR; IRDN; IDDM1; IDDM2; MODY10; proinsulin; preproinsulin; insulin-dependent diabetes mellitus 2; OTTHUMP00000011161; OTTHUMP00000011162; OTTHUMP00000196036; OTTHUMP00000196038; OTTHUMP00000217519;
- Recombinant Proteins
- Cell & Tissue Lysates
- Transfected Stable Cell Lines
- Protein Pre-coupled Magnetic Beads
- Therapeutic Proteins
- Native Proteins
- Beef
- Bovine
- Cattle
- Chicken
- Cynomolgus Monkey
- Guinea pig
- Horse
- Human
- Mouse
- Pig
- Pongo pygmaeus
- Rabbit
- S.cerevisiae
- Zebrafish
- Beef Pancreas
- Bovine pancreas
- E.coli
- HEK293
- Human
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Porcine Pancreas
- S.cerevisiae
- Wheat Germ
- Yeast
- Flag
- GST
- His
- His (Fc)
- Avi
- His|GST
- His|SUMO
- Met|His|Lys
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
INS involved in several pathways and played different roles in them. We selected most pathways INS participated on our site, such as Ras signaling pathway, Rap signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with INS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Ras signaling pathway | RASA4;Kitl;ABL1;MAPK8;LOC608458;GNB3;GRIN2A;FIGF;PAK2 |
Rap signaling pathway | CALM4;GRIN1;BRAF;KIT;MAP2K3;ITGA2B;KITLG;PIK3CB;Fgf15 |
cGMP-PKG signaling pathway | CREB3L1;PRKG1;NPPB;NOS3;ATP2A1;ATP1B3;PIK3CD;KCNJ8;INS1 |
HIF- signaling pathway | ALDOA;EP300;TF;NOS2;PFKL;IGF1R;EPO;TCEB1;IGF1 |
FoxO signaling pathway | FOXO3;FBXO25;STAT3;IRS4;PLK1;SGK1;PRKAB1A;MAPK10;G6PC3 |
Phospholipase D signaling pathway | CYTH2;Pdgfa&Pdgfb;DNM3;INS1;AGPAT3;RHOA;PIK3R3;PLA2G4D;MRAS |
Oocyte meiosis | PPP2R5E;CDC26;PPP3CB;PRKACBA;PRKACAA;CALM2;RPS6KA3B;YWHAE1;CPEB3 |
Regulation of autophagy | GABARAPA;IFNPHI1;ATG16L1;IFNA13;IFNA8;IFNA12;IFNG1-2;ATG13;IFNG |
mTOR signaling pathway | BRAF;PRKAA2;ULK3;PIK3R5;PTENA;PRKAA1;VEGFA;MLST8;RPS6KB1 |
PIK-Akt signaling pathway | COL6A5;ITGA10;ANGPT4;CCNE1;Il2;GH2;ITGA5;GNG12;CRTC2 |
AMPK signaling pathway | IGF1R;Scd1;ADIPOR1;LEPR;FBP1;IRS1;PIK3CB;CAMKK1;HNF4A |
Regulation of actin cytoskeleton | ITGA7;RAC1A;Fgf15;INSRR;CYFIP2;HRASB;FGF6;FGF8A;FGD3 |
Insulin signaling pathway | MAP2K2;PRKAB1A;PCK1;PPARGC1A;AKT3A;PRKAA1;TSC1;PRKAR1A;PIK3CG |
Insulin secretion | ATP1A1;PRKACA;ATP1A2;PLCB4;CAMK2B;GNA11;SLC2A1;GCG;PLCB1 |
Ovarian steroidogenesis | INS2;STAR;HSD3B4;PLA2G4C;HSD3B1;SCARB1;HSD3B5;HSD3B2;AKR1C3 |
Progesterone-mediated oocyte maturation | Adcy4;CDC27;HSP90AA1.2;RPS6KA3;ADCY1A;GNAIA;ADCY1B;ANAPC5;IGF1RB |
Prolactin signaling pathway | PIK3R5;SOCS3;PIK3CD;ELF5;SOCS5;NRAS;AKT1;KRAS;MAPK11 |
Regulation of lipolysis in adipocytes | PNPLA2;AKT1;GNAI2;PTGER3;Adcy4;PRKG1;INS;PLIN1;PIK3CD |
Type II diabetes mellitus | IKBKB;PIK3CG;SLC2A4;PIK3CB;MAPK8;ADIPOQ;HK3;SOCS4;HK1 |
Insulin resistance | SREBF1;SLC27A5;PPP1CB;G6PCA.1;INSR;PIK3R3A;FOXO1;PRKAB1B;AKT2 |
Non-alcoholic fatty liver disease (NAFLD) | FASLG;MAPK8;INS1;ADIPOR2;RELA;NDUFA3;PRKAG1;PPARA;NDUFA1 |
Type I diabetes mellitus | HLA-DMA;FAS;HLA-DOB;HSPD1;Il2;CPE;HLA-DMB;FASLG;GAD2 |
Maturity onset diabetes of the young | HNF1A;MNX1;HNF4G;PKLR;HES1;HNF4A;INS1;NR5A2;NKX6 |
Aldosterone-regulated sodium reabsorption | ATP1A3;IGF1;FXYD2;SFN;PIK3R3;PRKCB;INSR;INS1;ATP1A4 |
Prostate cancer | GRB2;NRAS;BRAF;TCF7L2;SMARCA4;EP300;MAPK3;IKBKG;INS |
INS has several biochemical functions, for example, hormone activity, identical protein binding, insulin receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by INS itself. We selected most functions INS had, and list some proteins which have the same functions with INS. You can find most of the proteins on our site.
Function | Related Protein |
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hormone activity | PRL7B1;PTHLHA;FAM132A;PRL2;FNDC5B;INS;PRL3B1;PTH1B;URP2 |
identical protein binding | SCUBE1;ETNPPL;PLDN;LCK;GRB7;ALK;SHANK1;APOA1;SDCBP |
insulin receptor binding | PTPN11;DOK6;IGF2;PDPK1;SNX2;DOK3;SNX4;FRS3;INS1 |
insulin-like growth factor receptor binding | GNAS;INS;SOCS1;REN;IGF2A;INSL4;SHC1;IGF3;IGF2B |
protease binding | SERPINA1E;LDLR;CSTA;BRCA2;INSL3;TIMP2;NDUFS7;ECM1;BDKRB2 |
protein binding | MYO5A;P2RX4;FAM153C;FBXW8;C1orf109;PEX12;MED19;CUTA;CCDC22 |
INS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with INS here. Most of them are supplied by our site. Hope this information will be useful for your research of INS.
DCN; MAPK6
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