Recombinant Pongo pygmaeus INS1 Protein

• Cat.No.: INS-64P
• Product Overview: Recombinant Pongo pygmaeus INS1 Protein was expressed in E. coli.

Specification

• Description: This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified, including insulin-dependent diabetes mellitus, permanent neonatal diabetes diabetes mellitus, maturity-onset diabetes of the young type 10 and hyperproinsulinemia. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region.
• Source: E. coli
• Species: Pongo pygmaeus
• Form: Liquid. In 1xPBS, PH 7.4.
• Molecular Mass: ~9.4 kDa
• AA Sequence: FVNQHLCGSHLVEALYLVCGERGFF YTPKTRREAEDLQVGQVELGGGPGA GSLQPLALEGSLQKRGIVEQCCTS ICSLYQLENYCN
• Purity: >90%
• Storage: Short Term Storage at 4 centigrade, Long Term, please prepare aliquots with 20% glycerol and store at -20-80 centigrade. Avoid freeze/thaw cycles.
• Concentration: 0.2 mg/ml

Gene Information

• Gene Name: INS insulin [ Pan troglodytes (chimpanzee) ]
• Official Symbol: INS
• Synonyms: IDDM; ILPR; IRDN; IDDM1; IDDM2; PNDM4; MODY10
• Gene ID: 449570
• mRNA Refseq: NM_001008996
• Protein Refseq: NP_001008996
• UniProt ID: Q8HXV2