Address: 45-1 Ramsey Road, Shirley, NY 11967, USA    USA: 1-631-559-9269  1-631-448-7888   Fax: 1-631-938-8127  Europe: 44-207-097-1828   Email: info@creative-biomart.com
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Your Position:  Home >> Services >> Enzyme Target and Screening

Enzyme Target and Screening

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Enzymes are attractive targets for pharmacological intervention, owing to their essential roles in life processes and pathophysiology. Because of their critical roles in the study of drug metabolism, pharmacokinetics and toxicity reactions, the demand for the new enzyme assay development is increasing. Creative BioMart is committed to developing a variety of comprehensive assays. In addition to the popular kinase and protease assay panels, Creative BioMart offers miscellaneous enzyme assay services, including but not limited to, lipases, oxidoreductases, deacetylases, CYP450 enzymes, and phosphodiesterases (PDE), all of which have been identified as prospective druggable entities.

Featured Services:

  • Assay reagent preparation
  • Assay development for high throughput screening
  • High throughput screening and profiling

Vailable Enzyme Family including:

  • Enzyme Family
  • Enzyme Name
 
  • Cytochrome P450
  • 1A2, 2C9, 2C19, 2D6, 3A4
 
  • Oxidoreductases
  • MAO-A, MAO-B, COX-1, COX-2
 
  • Transferases
  • COMT, UGT1A1
 
  • Deacetylase
  • Sirtuin SIRT1, Sirtuin SIRT2, Sirtuin SIRT3
 
  • Hydrolases
  • Pancreatic Lipase (Porcine), Pancreatic Lipase, α-Amylase, α-Glucosidase, Sucrase (Invertase), Na+/K+-ATPase (Porcine), Cholinesterase, Acetyl (AchE)
 
  • Lyases
  • Carbonic Anhydrase (CA)
 
  • Hydrolases, Phosphatase
  • PTP1B, TCPTP, CD45, SHP-2
 
  • Hydrolases, Phosphodiesterase
  • PDE1A, PDE1B, PDE1C, PDE2A, PDE3A, PDE3B, PDE4A1A, PDE4B1, PDE4B2, PDE4C1, PDE4D2, PDE4D3, PDE5A1, PDE6C, PDE7A, PDE7B, PDE8A1, PDE9A2, PDE10A1, PDE11A4
 

Creative BioMart is specialized on testing inhibitors against total enzymatic activity as well as high throughput screening for individual DNMTs, HMTs, HDMTs, HDACs and HATS. The comprehensive panel of enzymes in this platform has important biological and therapeutic relevance. Misregulation of these enzymes may lead to disease such as cancer. Inhibitors that target to these enzymes such as HDACs and DNMTs have been proven effective as novel cancer therapeutic agents. Continued development of these inhibitors, especially isoform-selective inhibitors, would further improve cancer treatment and lead to the possibility of successful cancer treatment drugs.

Welcome to contact us or send an email to info@creative-biomart.com for project quotations and more detailed information.
45-1 Ramsey Road, Shirley, NY 11967, USA
USA: 1-631-559-9269  1-631-448-7888
Europe: 44-207-097-1828
FAX: 1-631-938-8127
EMAIL: info@creative-biomart.com

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