Ganglioside GM2 (sodium salt) is isolated from bovine brain.
Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GM2 is a very minor component of the nervous system, but it is accumulated in brains from Tay-Sachs and Sandhoff disease patients, due to genetic defect of lysosomal β-hexosaminidase.
Stable for at least 2 years after receipt when stored at -20°C.
Short Term Storage +4°C
Long Term Storage -20°C
Soluble in water (liposomal aggregates) or chloroform:methanol (2:1).