MRGPRX2 CHO-K1 β-Arrestin GPCR Assay Kit

• Cat.No.: Kit-1425
• Product Overview: β-Arrestin GPCR cells are engineered to co-the ProLink (PK) tagged GPCR and the Enzyme Acceptor (EA) tagged β-Arrestin. Activation of the GPCR-PK induces β-Arrestin-EA recruitment, forcing complementation of the two β-galactosidase enzyme fragments (EA and PK). The resulting functional enzyme hydrolyzes substrate to generate a chemiluminescent signal. These cells have been modified to prevent long term propagation and expansion using a proprietary compound that has no apparent effect on assay performance.

Specification

• Size: 100 dp(1 x 96-well)/200 dp(2 x 96-well)/1000 dp(10 x 96-well)
• Storage: Short term (2 weeks): Store in vapor phase of liquid N2

Reviews

05/27/2019

Beyond its superb performance in Western blotting, the MRGPRX2 protein has also proven invaluable in protein electron microscopy structure analysis.

01/06/2017

Its versatility and reliability make it an excellent choice for researchers seeking to delve deeper into the mechanisms and functions of the MRGPRX2 protein.

03/31/2016

the MRGPRX2 protein comes highly recommended for its exceptional performance in Western blot analysis and its utility in protein electron microscopy structure analysis.

Q&As

How does MRGPRX2 contribute to allergic reactions?

MRGPRX2 activation on mast cells can lead to the release of histamine and other pro-inflammatory substances, contributing to allergic reactions.

Are there any drugs that specifically target MRGPRX2?

Some experimental drugs targeting MRGPRX2 are under investigation for their potential in treating allergic and inflammatory conditions.

Can MRGPRX2 be a target for pain management?

There is emerging research exploring the role of MRGPRX2 in pain modulation, making it a potential target for pain management strategies.

Can targeting MRGPRX2 be a therapeutic approach for allergic conditions?

Research suggests that modulating MRGPRX2 activity could be a potential therapeutic strategy for managing allergic conditions.

Are there any diseases or conditions associated with dysregulation of MRGPRX2?

Dysregulation of MRGPRX2 has been implicated in conditions such as chronic urticaria and certain inflammatory disorders.